New genetic resources for mammalian developmental biologists

The utilization of homologous recombination in embryonic stem cells as a means to generate mice carrying pre-determined modifications of genomic sequences has revolutionized the study of developmental biology. Recognizing the potential efficiencies that can be obtained by high-throughput production at centralized technology centers, a number of large-scale efforts for generating mice with targeted mutations have been funded. These programs are reaching fruition, and a variety of libraries of embryonic stem cells with defined mutations are now available.

• Publication year

  2010

• Venue

  F1000 Biology Reports

• Publication date

  2010-10-12

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.3410/B2-72PMID 21173845PMCID 2989628
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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