Objective. To study the association of genetic determinant (A-risk allele of rs9939609 SNP of FTO gene) with prevalence of metabolic syndrome (MS) and its components in residents of different Russian cities. Design and methods. We examined 425 patients with MS or its components from different cities of Russia (St Petersburg, Kursk, Kaliningrad), stratiied by sex and age [175 male (41,2 %) and 250 female (58,8 %), mean age — 47,2 ± 0,6 years]. All subjects were interviewed with special questionnaire. Physical examination included anthropometry (waist and hip circumferences, weight, height), blood pressure and heart rate registration. MS was deined according to NCEP-ATPIII as well as IDF (2005) and JIS (2009) criteria. Fasting plasma lipids and glucose were performed in all patients by Hitachi-902 equipment (Roche reagents). Genomic deoxyribonucleic acid (DNA) was puriied from peripheral blood lymphocytes and genotyping was performed using real time polymerase chain reaction method by allele-speciic probes (Applied Biosystems). Results. Among males with AA genotype waist and hip circumferences and weight were higher, compared to subjects with TA and TT genotypes (p = 0,0002, p = 0,001 and p = 0,01, respectively). There was a tendency to the increase of body mass index (BMI) in the group with AA genotype compared to subjects with TA and TT genotypes (29,7 ± 0,7; 27,6 ± 0,4 and 27,9 ± 0,3 kg/m 2 , respectively, р = 0,1). In our study AA genotype was associated with higher glucose level compared to TA and TT genotypes (5,6 ± 0,2; 5,0 ± 0,1 and 5,1 ± 0,1 mmol/l, respectively, p = 0,04). There was a tendency to the increase of the proportion of hypertensives among patients with AA genotype compared to TA and TT genotypes (70,5; 65,2 and 57 %, respectively, p = 0,18). Conclusion. In Russian population FTO genepolymorphism rs9969309 is associated not only with abdominal obesity, but also with other components of MS, including hyperglycemia and hypertension.
Взаимосвязь rs9939609 полиморфизма гена fto с метаболическим синдромом и его компонентами в Российской популяции
Наталья Вячеславовна Хромова,Оксана Петровна Ротарь,Анастасия Максимовна Ерина,Д. А. Шавшин,Нина Петровна Алексеева,Анна Александровна Костарева,Александра Олеговна Конради,Евгений Владимирович Шляхто
Published 2013 in Arterial’naya Gipertenziya
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- Publication year
2013
- Venue
Arterial’naya Gipertenziya
- Publication date
2013-08-28
- Fields of study
Biology, Medicine
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