In vitro propagation and production of cardiotonic glycosides in shoot cultures of Digitalis purpurea L. by elicitation and precursor feeding

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Applied Microbiology and Biotechnology

• Publication date

  2013-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s00253-012-4489-yPMID 23081776
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Increased cardenolides production by elicitation of Digitalis lanata shoots cultured in temporary immersion systems

  2012influential reference
• Identification of Medicinally Active Ingredient in Ultradiluted Digitalis purpurea: Fluorescence Spectroscopic and Cyclic-Voltammetric Study

  2012cited by this paper
• Comprehensive transcriptome analysis reveals novel genes involved in cardiac glycoside biosynthesis and mlncRNAs associated with secondary metabolism and stress response in Digitalis purpurea

  2012cited by this paper
• Influence of growth regulators and elicitors on cell growth and α-tocopherol and pigment productions in cell cultures of Carthamus tinctorius L.

  2011influential reference
• Effects of plant growth regulators and elicitors on production of secondary metabolites in shoot cultures of Hypericum hirsutum and Hypericum maculatum

  2011cited by this paper
• Effects of macro elements and nitrogen source on biomass accumulation and bacoside A production from adventitious shoot cultures of Bacopa monnieri (L.)

  2011cited by this paper
• Micropropagation of Uraria picta through adventitious bud regeneration and antimicrobial activity of callus

  2011cited by this paper
• Direct shoot regeneration from leaf explants of Digitalis lamarckii, an endemic medicinal species

  2011influential reference
• Regeneration and cardiotonic glycoside production in Digitalis davisiana Heywood (Alanya Foxglove)

  2010influential reference
• Digitalis purpurea P5 beta R2, encoding steroid 5 beta-reductase, is a novel defense-related gene involved in cardenolide biosynthesis.

  2010cited by this paper
• Effects of biotic and abiotic elicitors on cell growth and tanshinone accumulation in Salvia miltiorrhiza cell cultures

  2010cited by this paper
• Accumulation of salicylic acid-induced phenolic compounds and raised activities of secondary metabolic and antioxidative enzymes in Salvia miltiorrhiza cell culture.

  2010cited by this paper
• Micropropagation of Teucrium fruticans L., an ornamental and medicinal plant

  2009cited by this paper
• Cardiotonic glycosides from biomass of Digitalis purpurea L. cultured in temporary immersion systems

  2009influential reference
• Purification and characterization of malonyl-coenzyme A: 21-hydroxypregnane 21-O-malonyltransferase (Dp21MaT) from leaves of Digitalis purpurea L.

  2008cited by this paper
• Molecular aspects of the early stages of elicitation of secondary metabolites in plants

  2007cited by this paper
• Effects of methyl jasmonate and salicylic acid on the production of bilobalide and ginkgolides in cell cultures of Ginkgo biloba

  2007cited by this paper
• Digitoxin as an anticancer agent with selectivity for cancer cells: possible mechanisms involved

  2007cited by this paper
• Different biotic and abiotic elicitors influence betalain production in hairy root cultures of Beta vulgaris in shake-flask and bioreactor

  2006cited by this paper
• Liquid culture systems for in vitro plant propagation

  2005cited by this paper
• Comparison of secondary plant metabolite production in cell suspension, callus culture and temporary immersion system

  2005cited by this paper
• Metabolic profiling of Medicago truncatula cell cultures reveals the effects of biotic and abiotic elicitors on metabolism.

  2005cited by this paper
• Elicitor signal transduction leading to production of plant secondary metabolites.

  2005influential reference
• Elicitation of diosgenin production in Dioscorea floribunda by ethylene-generating agent.

  2005cited by this paper
• New Camptothecin and Ellagic Acid Analogues from the Root Bark of Camptotheca acuminata

  2004cited by this paper
• Biotechnology for the production of plant secondary metabolites

  2004cited by this paper
• PLANT CELL CULTURES AN ALTERNATIVE AND EFFICIENT SOURCE FOR THE PRODUCTION OF BIOLOGICALLY IMPORTANT SECONDARY METABOLITES

  2004cited by this paper
• Enzymes in cardenolide-accumulating shoot cultures of Digitalis purpurea L.

  2004cited by this paper
• Enhancement of Tanshinone Production in Salvia miltiorrhiza Hairy Root Culture by Ag+ Elicitation and Nutrient Feeding

  2004cited by this paper
• Positive Inotropic Effect of Ouabain on Isolated Heart Is Accompanied by Activation of Signal Pathways that Link Na+/K+-ATPase to ERK1/2

  2003cited by this paper
• The Na, K-ATPase in the failing human heart.

  2003cited by this paper
• Anti-tumour activity of Digitalis purpurea L. subsp. heywoodii.

  2003cited by this paper
• Plant cell cultures: Chemical factories of secondary metabolites.

  2002cited by this paper
• Na(+)/K(+)-ATPase as a signal transducer.

  2002cited by this paper
• Plant hormones and Agrobacterium tumefaciens strain 82.139 induce efficient plant regeneration in the cardenolide-producing plant Digitalis minor

  2002cited by this paper
• Cardenolides and cancer.

  2001cited by this paper
• The Merck index : an encyclopedia of chemicals, drugs, and biologicals

  2001cited by this paper
• Effect of osmotic pressure on paclitaxel production in suspension cell cultures of Taxus chinensis.

  2001cited by this paper
• Digitoxin medication and cancer; case control and internal dose-response studies

  2001cited by this paper
• Effects of stress factors, bioregulators, and synthetic precursors on indole alkaloid production in compact callus clusters cultures of Catharanthus roseus

  2001influential reference
• Bioreactors for plant engineering: an outlook for further research

  2000cited by this paper
• Cardiovascular activity of a methanolic extract of Digitalis purpurea spp. heywoodii.

  2000cited by this paper
• The influence of different biotic and abiotic elicitors on the production and profile of tropane alkaloids in hairy root cultures of Brugmansia candida.

  2000cited by this paper
• Improved alkaloid production in Catharanthus roseus suspension cell cultures by various chemicals

  2000cited by this paper
• Digitoxin is a potential anticancer agent for several types of cancer.

  1999cited by this paper
• Cardenolide biosynthesis in light- and dark-grown Digitalis lanata shoot cultures

  1999cited by this paper
• The Merck index

  1998cited by this paper
• Extensive Reprogramming of Primary and Secondary Metabolism by Fungal Elicitor or Infection in Parsley Cells

  1998cited by this paper
• Cardenolides of Digitalis obscura: The effect of phosphate and manganese on growth and productivity of shoot-tip cultures

  1997cited by this paper
• Salicylate, superoxide synthesis and cell suicide in plant defence

  1997cited by this paper
• Biosynthesis of pregnane derivatives in somatic embryos of Digitalis lanata

  1997cited by this paper
• Methyl jasmonate-induced overproduction of paclitaxel and baccatin III in Taxus cell suspension cultures

  1996cited by this paper
• The use of digitalis in heart failure.

  1996cited by this paper
• Elicitation of Taxus sp. cell cultures for production of taxol

  1995cited by this paper
• Influence of the carbon source on growth and rosmarinic acid production in suspension cultures of Coleus blumei

  1993cited by this paper
• Elicitation of thiophene production by hairy roots of Tagetes patula.

  1992cited by this paper
• Somatic embryogenesis and shoot regeneration from intact seedlings of Phaseolus acutifolius A., P. aureus (L.) Wilczek, P. coccineus L., and P. wrightii L.

  1992cited by this paper
• Effect of thidiazuron, light fluence rates and kanamycin on in vitro shoot organogenesis from excised Rubus cotyledons and leaves

  1990cited by this paper
• Studies on Alkaloid Formation in Plant Cell Cultures After Treatment with a Yeast Elicitor

  1989cited by this paper
• Primary and Secondary Metabolism of Plant Cell Cultures II

  1989cited by this paper
• UDP-glucose:digitoxin 16′-O-glucosyltransferase from suspension-cultured Digitalis lanata cells

  1986cited by this paper
• Cultivation and breeding of Digitalis lanata in the Netherlands.

  1985cited by this paper
• Plant cell culture : a practical approach

  1985cited by this paper
• Photoautotrophic Culture of Undifferentiated Cells and Shoot-Forming Cultures of Digitalis purpurea L.

  1984cited by this paper
• Studies on the production of digitalis cardenolides by plant tissue culture

  1984cited by this paper
• Effects of Mineral Salts, Initial pH and Precursors on Digitoxin Formation by Shoot-forming Cultures of Digitalis purpurea L. Grown in Liquid Media

  1983influential reference
• Studies on the Production of Digitalis Cardenolides by Plant Tissue Culture: II. EFFECT OF LIGHT AND PLANT GROWTH SUBSTANCES ON DIGITOXIN FORMATION BY UNDIFFERENTIATED CELLS AND SHOOT-FORMING CULTURES OF DIGITALIS PURPUREA L. GROWN IN LIQUID MEDIA.

  1982influential reference
• Growth, Morphogenesis and Cardenolide Formation in Long-term Cultures of Digitalis lanata1

  1980cited by this paper
• Growth, Morphogenesis and Cardenolide Formation in Long-term Cultures of Digitalis lanata1

  1980influential reference
• Effects of precursors on serially propagated Digitalis lanata leaf and root cultures

  1979influential reference
• Restoration of cardenolide-synthesis in redifferentiated shoots from callus cultures of Digitalis purpurea

  1977influential reference
• Wurzeldifferenzierung and Glykosidbildung bei in vitro kultivierten Blattexplantaten von Digitalis purpurea L.

  1976cited by this paper
• Steroid hormones in plants.

  1975cited by this paper
• [Biotransformation of cholesterol-26-14C by tissue cultures of Evonymus europaea and Digitalis purpurea].

  1974cited by this paper
• Flora of Alaska and neighboring territories.

  1968cited by this paper
• Biosynthesis of plant sterols. VII. The possible operation of several routes in the biosynthesis of cardenolides from cholesterol.

  1968cited by this paper
• Transformation of Pregnenolone and Progesterone by Cultured Plant Cells

  1967cited by this paper
• A revised medium for rapid growth and bio assays with tobacco tissue cultures

  1962cited by this paper

• Climate change and medicinal plant biodiversity: conservation strategies for sustainable use and genetic resource preservation

  2025cites this paper
• Trends in plant tissue culture, production, and secondary metabolites enhancement of medicinal plants: a case study of thyme

  2025cites this paper
• Extreme temperatures elicit the accumulation of cardiac glycoside and their genin units in Calotropis procera by altering the expression of transcripts involved in its biosynthesis

  2025cites this paper
• Elicitor-mediated enhancement of secondary metabolites in plant species: a review

  2025cites this paper
• Cardiac glycosides: structural diversity, chemical ecology, bioactivity, and artificial synthesis.

  2025cites this paper
• Optimization of elicitation and precursor feeding for enhancement of in vitro production of diosgenin in shoot cultures of Dioscorea deltoidea

  2025cites this paper
• Elicitation: “A Trump Card” for Enhancing Secondary Metabolites in Plants

  2024cites this paper
• A comprehensive review of in vitro precursor feeding strategies for the overproduction of high-value plant secondary metabolites

  2024cites this paper
• Digitalis purpurea L. Propagated in Vitro with Various Hormones

  2024influential citation
• Effect of abiotic and biotic elicitors on vincristine accumulation in endosperm derived in vitro cultures in Catharanthus roseous (L.) G. Don

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• Effective Biotic Elicitors for Augmentation of Secondary Metabolite Production in Medicinal Plants

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• Metabolic Effects of Elicitors on the Biosynthesis of Tropane Alkaloids in Medicinal Plants

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  2022cites this paper
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  2014influential citation
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  2014cites this paper
• Cardiotonic Activity of Alcoholic Bark Extract of Xylocarpus Granatum with Emphasis on Its Mechanism of Action

  2013cites this paper
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  year unknowncites this paper