The Pneumocystis carinii drug target S‐adenosyl‐L‐methionine:sterol C‐24 methyl transferase has a unique substrate preference

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Molecular Microbiology

• Publication date

  2002-05-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1046/j.1365-2958.2002.02932.xPMID 12010494
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Transport of aspartic acid, arginine, and tyrosine by the opportunistic protist Pneumocystis carinii.

  2001cited by this paper
• Sterol methyl transferase: enzymology and inhibition.

  2000influential reference
• Inhibitors of Sterol Biosynthesis and Amphotericin B Reduce the Viability of Pneumocystis carinii f. sp.carinii

  2000cited by this paper
• Sterols of Pneumocystis carinii hominis Organisms Isolated from Human Lungs

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• STEROL METHYLTRANSFERASE 1 Controls the Level of Cholesterol in Plants

  2000cited by this paper
• Sterol C-methyl transferase from Prototheca wickerhamii mechanism, sterol specificity and inhibition.

  2000influential reference
• C27 to C32 sterols found in Pneumocystis, and opportunistic pathogen of immunocompromised mammals

  2000cited by this paper
• Sterol methyl transferase: enzymology and inhibition.

  2000cited by this paper
• Pneumocystis carinii dihydropteroate synthase but not dihydrofolate reductase gene mutations correlate with prior trimethoprim-sulfamethoxazole or dapsone use.

  1999cited by this paper
• Continuous axenic cultivation of Pneumocystis carinii.

  1999cited by this paper
• Sterols of Pneumocystis carinii hominisOrganisms Isolated from Human Lungs

  1999cited by this paper
• Pneumocysterol [(24Z)-ethylidenelanost-8-en-3beta-ol], a rare sterol detected in the opportunistic pathogen Pneumocystis carinii hominis: structural identity and chemical synthesis.

  1999cited by this paper
• Overexpression, Purification, and Stereochemical Studies of the Recombinant (S)-Adenosyl-l-methionine: Δ24(25)- to Δ24(28)-Sterol Methyl Transferase Enzyme fromSaccharomyces cerevisiae

  1998cited by this paper
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  1998cited by this paper
• Overexpression, purification, and stereochemical studies of the recombinant (S)-adenosyl-L-methionine: delta 24(25)- to delta 24(28)-sterol methyl transferase enzyme from Saccharomyces cerevisiae.

  1998cited by this paper
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  1998cited by this paper
• Sequencing, Disruption, and Characterization of the Candida albicans Sterol Methyltransferase (ERG6) Gene: Drug Susceptibility Studies in erg6 Mutants

  1998cited by this paper
• Two families of sterol methyltransferases are involved in the first and the second methylation steps of plant sterol biosynthesis.

  1998cited by this paper
• Identification of cDNAs encoding sterol methyl-transferases involved in the second methylation step of plant sterol biosynthesis.

  1997influential reference
• Characterization of Zea mays endosperm C-24 sterol methyltransferase: one of two types of sterol methyltransferase in higher plants

  1997cited by this paper
• Inhibitors of delta24(25) sterol methyltransferase block sterol synthesis and cell proliferation in Pneumocystis carinii

  1997cited by this paper
• Stereochemistry of yeast delta 24-sterol methyl transferase.

  1997cited by this paper
• Stereochemistry of yeast Δ24-sterol methyl transferase

  1997cited by this paper
• Mechanism and structural requirements for transformation of substrates by the (S)-adenosyl-L-methionine:delta 24(25)-sterol methyl transferase from Saccharomyces cerevisiae.

  1996cited by this paper
• Identification and Characterization of an S-Adenosyl-L-methionine:-Sterol-C-methyltransferase cDNA from Soybean (*)

  1996cited by this paper
• Pneumocystis carinii: what is it, exactly?

  1996cited by this paper
• Sterol specificity of theSaccharomyces cerevisiae ERG6 gene product expressed inEscherichia coli

  1996cited by this paper
• Transformation of Saccharomyces cerevisiae with a cDNA encoding a sterol C‐methyltransferase from Arabidopsis thaliana results in the synthesis of 24‐ethyl sterols

  1996cited by this paper
• Pneumocystis carinii.

  1996cited by this paper
• Identification of 24-methylene-24,25-dihydrolanosterol as a precursor of ergosterol in the yeasts Schizosaccharomyces pombe and Schizosaccharomyces octosporus.

  1995cited by this paper
• Evidence for the Presence of “Metabolic Sterols” in Pneumocystis: Identification and Initial Characterization of Pneumocystis carinii Sterols

  1994influential reference
• Phytosterols are present in Pneumocystis carinii

  1994cited by this paper
• Occurrence of specific sterols in Pneumocystis carinii.

  1994cited by this paper
• Characterization of Pneumocystis carinii Preparations Developed for Lipid Analysis

  1993cited by this paper
• Genetic stability and diversity of Pneumocystis carinii infecting rat colonies

  1993cited by this paper
• Improved rat model of Pneumocystis carinii pneumonia: induced laboratory infections in Pneumocystis-free animals

  1992cited by this paper
• Mechanism and inhibition of delta 24-sterol methyltransferase from Candida albicans and Candida tropicalis.

  1989influential reference
• Synthesis and Biological Evaluation of Fungal Bioregulators of Sterol Biosynthesis

  1987cited by this paper
• Chemistry in the Annonaceae. XXIII: 24-Methylene-lanosta-7,9(11)-dien-3β-ol from Artabotrys odorotissimus stem bark

  1987influential reference
• The lipid composition and permeability to azole of an azole- and polyene-resistant mutant of Candida albicans.

  1987cited by this paper
• Principles and practice of infectious diseases. Vols 1 and 2.

  1979cited by this paper
• Fatty acids and sterols of Cronartium fusiforme basidiospores.

  1977cited by this paper
• A rapid method of total lipid extraction and purification.

  1959influential reference
• Protein measurement with the Folin phenol reagent.

  1951cited by this paper

• Methylation of Unactivated Alkenes with Engineered Methyltransferases To Generate Non-natural Terpenoids.

  2023cites this paper
• Amino Acid Metabolism and Transport Mechanisms as Potential Antifungal Targets

  2018cites this paper
• Sterols of Saccharomyces cerevisiae erg6 Knockout Mutant Expressing the Pneumocystis carinii S‐Adenosylmethionine:Sterol C‐24 Methyltransferase

  2015cites this paper
• Studies on sterol metabolism in the opportunistic pathogen Pneumocystis carinii

  2013cites this paper
• Optimization and Expression of the Pneumocystis carinii erg6 Gene in a Saccharomyces cerevisiae erg6 Deletion Mutant

  2011cites this paper
• Pneumocystis carinii Sterol 14α‐Demethylase Activity in Saccharomyces cerevisiae erg11 Knockout Mutant: Sterol Biochemistry

  2011cites this paper
• Biochemical research elucidating metabolic pathways in Pneumocystis.

  2010cites this paper
• Sterol biosynthesis and sterol uptake in the fungal pathogen Pneumocystis carinii.

  2010cites this paper
• Cloning, mechanistic and functional analysis of a fungal sterol C24-methyltransferase implicated in brassicasterol biosynthesis.

  2010cites this paper
• Functional Characterization and Localization of Pneumocystis carinii Lanosterol Synthase

  2009cites this paper
• Plant Sterol Methyltransferases: Phytosterolomic Analysis, Enzymology, and Bioengineering Strategies

  2008cites this paper
• Molecular probing of the Saccharomyces cerevisiae sterol 24-C methyltransferase reveals multiple amino acid residues involved with C2-transfer activity.

  2008cites this paper
• Pneumocystis jiroveci Pneumonia

  2008cites this paper
• Antifungal activity of 25-azalanosterol against Candida species

  2008cites this paper
• Photoaffinity Labeling and Mutational Analysis of 24-C-Sterol Methyltransferase Defines the AdoMet Binding Site

  2008cites this paper
• Transcriptome of Pneumocystis carinii during Fulminate Infection: Carbohydrate Metabolism and the Concept of a Compatible Parasite

  2007cites this paper
• Current insights into the biology and pathogenesis of Pneumocystis pneumonia

  2007cites this paper
• Enzyme redesign and interactions of substrate analogues with sterol methyltransferase to understand phytosterol diversity, reaction mechanism and the nature of the active site.

  2005cites this paper
• Pneumocystis Genome Project and Genomic Organization

  2004cites this paper
• Medical progress: Pneumocystis pneumonia

  2004cites this paper
• Sterol Composition of Pneumocystis jirovecii with Blocked 14α-Demethylase Activity

  2004cites this paper
• Sterol metabolism in the opportunistic pathogen Pneumocystis: Advances and new insights

  2004cites this paper
• Nomenclature and Genetic Variation of Pneumocystis

  2004cites this paper
• Enzyme mechanisms for sterol C-methylations.

  2003cites this paper
• Characterization of a lanosterol 14 alpha-demethylase from Pneumocystis carinii.

  2003cites this paper
• Sterol methyltransferase2: purification, properties, and inhibition.

  2003cites this paper
• Characterization of a lanosterol 14α-demethylase from Pneumocystis carinii

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• Biosynthesis of Phytosterols

  2003cites this paper
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  2003cites this paper
• Evidence for Cholesterol Scavenging by Pneumocystis and Potential Modifications of Host‐Synthesized Sterols by the P. carinii SAM:SMT

  2003cites this paper
• Pneumocystis.

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• Comprehensive and definitive structural identities of Pneumocystis carinii sterols DOI 10.1194/jlr.M200113-JLR200

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• Is Pneumocystis a Plant?

  2002cites this paper
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• Evidence for multiple sterol methyl transferase pathways in Pneumocystis carinii

  2002cites this paper