The colony ration supplied to guinea pigs in rhis laboratory has been reasonably satisfactory for growth and reproduCtion. Ie concains 1.2 percent of c21cium and 0.9 percent of phosphorus. However, mature animals, over 18 months of age, at rimes develop sore md Stiff joines, followed in some cases by visible deposits of calcium phosphate. If the amount of phosphorus in the nrion is increased to 1.6 percent the depoSits appear after about 19 weeks and presumably they will develop in every animal that survives the normal life span. A synrhetic d iet which conu.ined approximately 1 percent of calcium and 1 percent of phosphorus was less suitable for guinea pigs than was the colony diet. The animals grew more slowly and rhere was a low incidence of calcium phosphate deposirs when the animals were about 6 months old. When the phosphorus content of the diet was raised co 1.65 percent, the rate of growth was depressed still more, and half of the animals developed calcium phosphate deposits in an average time of 7 weeks. A small amount of evidence was obtained that the severity of the symptoms could ~ reduced by increasing the calcium content of the diet to 1.6, thus raising the calcium:phosphorus ratio to approxim:ue1y 3:2.
Effect on guinea pigs of consuming an excessive quantity of phosphates.
Published 1954 in Unknown venue
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1954
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Agricultural and Food Sciences, Chemistry, Biology
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