Divergent effect of fluoxetine on the response to physical or chemical stressors in zebrafish

Fluoxetine is a selective serotonin reuptake inhibitor that increases serotonin concentration in the central nervous system and modulates various systems, including the control of sympathetic outflow and the hypothalamus–pituitary–adrenal. However, it is not yet established whether fluoxetine can modulate the responses to stressors stimulants (physical or chemical) that trigger cortisol response in zebrafish. We demonstrate that fluoxetine blunts the response to physical stress, but not to chemical stress.

• Publication year

  2017

• Venue

  PeerJ

• Publication date

  2017-05-09

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.7717/peerj.3330PMID 28503384PMCID 5426348
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2015cited by this paper
• My stress, our stress: blunted cortisol response to stress in isolated housed zebrafish.

  2015cited by this paper
• Stress and fear responses in the teleost pallium.

  2015influential reference
• Effects of waterborne fluoxetine on stress response and osmoregulation in zebrafish.

  2015cited by this paper
• Serotonergic modulation of zebrafish behavior: towards a paradox.

  2014cited by this paper
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  2008cited by this paper
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• Emotion Circuits in the Brain

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• The amygdala.

  2000cited by this paper
• Chemical alarm signalling in aquatic predator-prey systems: A review and prospectus

  1998cited by this paper
• The stress response in fish.

  1997cited by this paper
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• Prozac (fluoxetine, Lilly 110140), the first selective serotonin uptake inhibitor and an antidepressant drug: twenty years since its first publication.

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