A protease-sensitive hinge linking the two domains of the hepatitis B virus core protein is exposed on the viral capsid surface

No abstract is available for this paper.

• Publication year

  1994

• Venue

  Journal of Virology

• Publication date

  1994-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/jvi.68.9.5548-5555.1994PMID 7520091PMCID PMC236955
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A micromolar pool of antigenically distinct precursors is required to initiate cooperative assembly of hepatitis B virus capsids in Xenopus oocytes

  1993cited by this paper
• Stability governs the apparent expression of "particulate" hepatitis B e antigen by mutant hepatitis B virus core particles.

  1993cited by this paper
• Epitopes recognized by antibodies to denatured core protein of hepatitis B virus.

  1993cited by this paper
• The position of heterologous epitopes inserted in hepatitis B virus core particles determines their immunogenicity

  1992cited by this paper
• RNA- and DNA-binding activities in hepatitis B virus capsid protein: a model for their roles in viral replication

  1992cited by this paper
• The arginine-rich domain of the hepatitis B virus core protein is required for pregenome encapsidation and productive viral positive-strand DNA synthesis but not for virus assembly

  1992cited by this paper
• Topological analysis of the hepatitis B virus core particle by cysteine-cysteine cross-linking.

  1992cited by this paper
• Cys residues of the hepatitis B virus capsid protein are not essential for the assembly of viral core particles but can influence their stability

  1992cited by this paper
• Hepatitis B virus capsid particles are assembled from core-protein dimer precursors.

  1992cited by this paper
• The structure of hepadnaviral core antigens. Identification of free thiols and determination of the disulfide bonding pattern.

  1992cited by this paper
• Characterization of hepatitis B virus capsid particle assembly in Xenopus oocytes

  1992cited by this paper
• Introduction of intersubunit disulfide bonds in the membrane-distal region of the influenza hemagglutinin abolishes membrane fusion activity.

  1992cited by this paper
• Phosphorylation in the carboxyl-terminal domain of the capsid protein of hepatitis B virus: evaluation with a monoclonal antibody

  1991influential reference
• Production of hepatitis B virus nucleocapsidlike core particles in Xenopus oocytes: assembly occurs mainly in the cytoplasm and does not require the nucleus

  1991cited by this paper
• Assembly of hepadnaviral virions and subviral particles.

  1991cited by this paper
• Characterisation of a linear binding site for a monoclonal antibody to hepatitis B core antigen

  1991cited by this paper
• Expression pattern of the hepatitis B virus genome in transfected mouse fibroblasts.

  1990cited by this paper
• Expression of hepatitis B virus core and precore antigens in insect cells and characterization of a core-associated kinase activity.

  1990cited by this paper
• Hepatitis B virus nucleocapsid assembly: primary structure requirements in the core protein

  1990influential reference
• Presentation and immunogenicity of viral epitopes on the surface of hybrid hepatitis B virus core particles produced in bacteria.

  1990cited by this paper
• Antigenic determinants and functional domains in core antigen and e antigen from hepatitis B virus

  1989cited by this paper
• The duck hepatitis B virus core protein contains a highly phosphorylated C terminus that is essential for replication but not for RNA packaging

  1989cited by this paper
• Antigenic sites on the arginine-rich carboxyl-terminal domain of the capsid protein of hepatitis B virus distinct from hepatitis B core or e antigen.

  1989cited by this paper
• Characterization of the major duck hepatitis B virus core particle protein

  1989cited by this paper
• A recombinant hepatitis B core antigen polypeptide with the protamine-like domain deleted self-assembles into capsid particles but fails to bind nucleic acids

  1989influential reference
• A signal peptide encoded within the precore region of hepatitis B virus directs the secretion of a heterogeneous population of e antigens in Xenopus oocytes.

  1988cited by this paper
• A model for the hepatitis B virus core protein: prediction of antigenic sites and relationship to RNA virus capsid proteins.

  1988cited by this paper
• Unusually high-level expression of a foreign gene (hepatitis B virus core antigen) in Saccharomyces cerevisiae.

  1986cited by this paper
• Immunochemical structure of hepatitis B e antigen in the serum.

  1983cited by this paper
• Structural basis of antibody function.

  1983cited by this paper
• Demonstration of two distinct antigenic determinants on hepatitis B e antigen by monoclonal antibodies.

  1982cited by this paper
• Synthesis of hepatitis B surface and core antigens in E. coli

  1981cited by this paper
• Tomato bushy stunt virus at 2.9 Å resolution

  1978cited by this paper

• Significance of hepatitis B virus capsid dephosphorylation via polymerase

  2024cites this paper
• Impact of DNA on interactions between core proteins of Hepatitis B virus-like particles comprising different C-terminals.

  2024cites this paper
• PreS1 Containing HBc VLPs for the Development of a Combined Therapeutic/Prophylactic Hepatitis B Vaccine

  2023cites this paper
• Transient RNA Interactions Leave a Covalent Imprint on a Viral Capsid Protein

  2022cites this paper
• Phosphorylation of the Arginine-Rich C-Terminal Domains of the Hepatitis B Virus (HBV) Core Protein as a Fine Regulator of the Interaction between HBc and Nucleic Acid

  2020cites this paper
• Hepatitis B core antigen virus-like particles : characterization and investigation 1 of their stability in simulated and pig gastro-intestinal fluids 2 3

  2018influential citation
• Clinical Implications of Hepatitis B Virus RNA and Covalently Closed Circular DNA in Monitoring Patients with Chronic Hepatitis B Today with a Gaze into the Future: The Field Is Unprepared for a Sterilizing Cure

  2018cites this paper
• Plant-expressed Hepatitis B core antigen virus-like particles: Characterization and investigation of their stability in simulated and pig gastro-intestinal fluids.

  2017influential citation
• Proteasomes regulate hepatitis B virus replication by degradation of viral core-related proteins in a two-step manner

  2016cites this paper
• The true story and advantages of the famous Hepatitis B virus core particles: Outlook 2016

  2016cites this paper
• Molecular Models for Hepatitis B Virus Capsid Formation, Maturation, and Envelopment

  2016cites this paper
• Preparation by alkaline treatment and detailed characterisation of empty hepatitis B virus core particles for vaccine and gene therapy applications

  2015cites this paper
• The Hepatitis B Virus Core Variants that Expose Foreign C-Terminal Insertions on the Outer Surface of Virus-Like Particles

  2015cites this paper
• A Thermodynamic Model for Genome Packaging in Hepatitis B Virus.

  2015cites this paper
• Analyse du transport intracytoplasmique de la capside du virus de l’hépatite B : analyse des interactions entre les capsides du VHB et les chaînes du complexe de la dynéine

  2014cites this paper
• Entecavir combined with furin inhibitor simultaneously reduces hepatitis B virus replication and e antigen secretion

  2014cites this paper
• Modification to the immunodominant loop of hepatitis B virus core protein to enhance vector properties of virus-like particles

  2014cites this paper
• A theoretical study of SRPK interaction with the flexible domains of hepatitis B capsids.

  2014cites this paper
• Epitope-distal effects accompany the binding of two distinct antibodies to hepatitis B virus capsids.

  2013cites this paper
• core assembled from full-length core protein.

  2013cites this paper
• Functional Role of Hepatitis B Virus Core Protein in Viral Replication

  2013cites this paper
• An Investigation into the Use of a Plant-Expressed Virus-Like Particle as an Oral Vaccine Candidate

  2013cites this paper
• 3.5Å cryoEM Structure of Hepatitis B Virus Core Assembled from Full-Length Core Protein

  2013cites this paper
• Therapeutic potential of furin inhibitors for the chronic infection of hepatitis B virus

  2013cites this paper
• A VLP Library of C-Terminally Truncated Hepatitis B Core Proteins: Correlation of RNA Encapsidation with a Th1/Th2 Switch in the Immune Responses of Mice

  2013cites this paper
• Structural Organization of Pregenomic RNA and the Carboxy-Terminal Domain of the Capsid Protein of Hepatitis B Virus

  2012cites this paper
• A theoretical model for the dynamic structure of hepatitis B nucleocapsid.

  2011cites this paper
• Regulation of hepadnavirus core protein function by phosphorylation

  2011cites this paper
• Structural comparisons of hepatitis B core antigen particles with different C-terminal lengths.

  2010cites this paper
• The role of mutations in core protein of hepatitis B virus in liver fibrosis

  2009cites this paper
• Nuclear Entry of Hepatitis B Virus Capsids Involves Disintegration to Protein Dimers followed by Nuclear Reassociation to Capsids

  2009cites this paper
• Clathrin-mediated Endocytosis and Lysosomal Cleavage of Hepatitis B Virus Capsid-like Core Particles*

  2006cites this paper
• Epitope diversity of hepatitis B virus capsids: quasi-equivalent variations in spike epitopes and binding of different antibodies to the same epitope.

  2006cites this paper
• Molecular epidemiology of human respiratory syncytial virus in Uruguay: 1985-2001--a review.

  2005cites this paper
• Cytokine Induction by the Hepatitis B Virus Capsid in Macrophages Is Facilitated by Membrane Heparan Sulfate and Involves TLR2

  2005cites this paper
• TLR2Membrane Heparan Sulfate and Involves Capsid in Macrophages Is Facilitated by Cytokine Induction by the Hepatitis B Virus

  2005cites this paper
• A Malaria Vaccine Candidate Based on a Hepatitis B Virus Core Platform

  2003cites this paper
• Stability and Morphology Comparisons of Self-AssembledVirus-Like Particles from Wild-Type and Mutant Human Hepatitis B VirusCapsidProteins

  2003cites this paper
• Conversion of poorly immunogenic malaria repeat sequences into a highly immunogenic vaccine candidate.

  2001cites this paper
• Intracellular Hepatitis B Virus Nucleocapsids Survive Cytotoxic T-Lymphocyte-Induced Apoptosis

  2000cites this paper
• Packaging of up to 240 subunits of a 17 kDa nuclease into the interior of recombinant hepatitis B virus capsids

  2000cites this paper
• The crystal structure of the human hepatitis B virus capsid.

  1999cites this paper
• Naturally occurring variants of hepatitis B virus.

  1999cites this paper
• Hepatitis B core particles as a universal display model: a structure‐function basis for development

  1999cites this paper
• Core particles of hepatitis B virus as carrier for foreign epitopes.

  1998cites this paper
• Duck Hepatitis B Virus Nucleocapsids Formed by N-Terminally Extended or C-Terminally Truncated Core Proteins Disintegrate during Viral DNA Maturation

  1998cites this paper
• Phosphorylation of the Core Protein of Hepatitis B Virus by a 46-Kilodalton Serine Kinase

  1998cites this paper
• Proline-138 is essential for the assembly of hepatitis B virus core protein.

  1998cites this paper
• Novel molecular approaches toward therapy of chronic hepatitis B

  1997cites this paper
• Folding and assembly of hepatitis B virus core protein: a new model proposal.

  1997cites this paper
• A hydrophobic heptad repeat of the core protein of woodchuck hepatitis virus is required for capsid assembly

  1996cites this paper
• Hepatitis B virus morphogenesis.

  1996cites this paper
• Core antigen mutations of human hepatitis B virus in hepatomas accumulate in MHC class II-restricted T cell epitopes.

  1995cites this paper
• Assembly and antigenicity of hepatitis B virus core particles.

  1995cites this paper
• Effect of core protein phosphorylation by protein kinase C on encapsidation of RNA within core particles of hepatitis B virus

  1994influential citation