Reduced [3H]flunitrazepam binding in cingulate cortex and hippocampus of postmortem schizophrenic brains: Is selective loss of glutamatergic neurons associated with major psychoses?

No abstract is available for this paper.

• Publication year

  1993

• Venue

  Neurochemical Research

• Publication date

  1993-02-01

• Fields of study

  Medicine, Chemistry, Psychology

• Identifiers
  DOI 10.1007/BF01474687PMID 8097289
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The distribution of 13 GABAA receptor subunit mRNAs in the rat brain. I. Telencephalon, diencephalon, mesencephalon

  1992influential reference
• The third gamma subunit of the gamma-aminobutyric acid type A receptor family.

  1992cited by this paper
• Widespread cerebral gray matter volume deficits in schizophrenia.

  1992cited by this paper
• Increased GABAA receptor binding in superficial layers of cingulate cortex in schizophrenics

  1992cited by this paper
• Deficits in small interneurons in prefrontal and cingulate cortices of schizophrenic and schizoaffective patients.

  1991influential reference
• A Viral-Anatomical Explanation of Schizophrenia

  1991cited by this paper
• Schizophrenia: A Neuropathological Perspective

  1991cited by this paper
• A review of evidence for GABergic predominance/glutamatergic deficit as a common etiological factor in both schizophrenia and affective psychoses: More support for a continuum hypothesis of “functional” psychosis

  1991cited by this paper
• A viral-anatomical explantation of schizophrenia.

  1991cited by this paper
• Glutamate‐, glutaminase‐, and taurine‐immunoreactive neurons develop neurofibrillary tangles in Alzheimer's disease

  1991influential reference
• Reduced neuronal size in posterior hippocampus of schizophrenic patients.

  1991influential reference
• Pronounced reduction of total neuron number in mediodorsal thalamic nucleus and nucleus accumbens in schizophrenics.

  1990cited by this paper
• Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia.

  1990cited by this paper
• Viruses, Immunity and Mental Disorder

  1989cited by this paper
• Polychlorinated Convulsant Insecticides Potentiate the Protective Effect of NaCl Against Heat Inactivation of [3H]Flunitrazepam Binding Sites

  1989cited by this paper
• Importance of a novel GABAA receptor subunit for benzodiazepine pharmacology

  1989cited by this paper
• Epilepsy, psychosis and schizophrenia.

  1988cited by this paper
• Mapping of brain areas containing RNA homologous to cDNAs encoding the alpha and beta subunits of the rat GABAA gamma-aminobutyrate receptor.

  1988cited by this paper
• Neuroanatomical Studies of Major Affective Disorders

  1988cited by this paper
• Quantitative neuroanatomy in schizophrenia. A controlled magnetic resonance imaging study.

  1988cited by this paper
• Glutamate-positive neurons in the somatic sensory cortex of rats and monkeys

  1987influential reference
• Resolving GABAA/benzodiazepine receptors: cellular and subcellular localization in the CNS with monoclonal antibodies

  1987cited by this paper
• [3H]muscimol binding sites increased in autopsied brains of chronic schizophrenics.

  1987cited by this paper
• Increased vertical axon numbers in cingulate cortex of schizophrenics.

  1987cited by this paper
• Quantitative cytoarchitectural studies of the cerebral cortex of schizophrenics.

  1986cited by this paper
• Postmortem evidence of structural brain changes in schizophrenia. Differences in brain weight, temporal horn area, and parahippocampal gyrus compared with affective disorder.

  1986cited by this paper
• Basal ganglia and limbic system pathology in schizophrenia. A morphometric study of brain volume and shrinkage.

  1985cited by this paper
• Different neuronal localization of aspartate-like and glutamate-like immunoreactivities in the hippocampus of rat, guinea-pig and Senegalese baboon (Papio papio), with a note on the distribution of gamma-aminobutyrate.

  1985cited by this paper
• Basal Ganglia and Limbic System Pathology in Schizophrenia: A Morphometric Study of Brain Volume and Shrinkage

  1985cited by this paper
• Glutamate‐ and GABA‐containing neurons in the mouse and rat brain, as demonstrated with a new immunocytochemical technique

  1984cited by this paper
• gamma-aminobutyric acid receptors modulate cation binding sites coupled to independent benzodiazepine, picrotoxin, and anion binding sites.

  1982cited by this paper
• Radiohistochemical localization of benzodiazepine receptors in rat brain.

  1980cited by this paper
• Gamma-aminobutyric acid in the brain in schizophrenia.

  1979cited by this paper
• Specific benzodiazepine receptors in rat brain characterized by high-affinity (3H)diazepam binding.

  1977cited by this paper
• High densities of benzodiazepine receptors in human cortical areas

  1977cited by this paper
• Glutamic acid: selective depletion by viral induced granule cell loss in hamster cerebellum.

  1974cited by this paper
• Isolated removal of hypothalamic or other brain nuclei of the rat.

  1973cited by this paper
• THE SYNAPTIC ORGANIZATION OF THE MALFORMED CEREBELLUM INDUCED BY PERINATAL INFECTION WITH THE FELINE PANLEUKOPENIA VIRUS (PLV): I. ELEMENTS FORMING THE CEREBELLAR GLOMERULI

  1971cited by this paper
• THE SYNAPTIC ORGANIZATION OF THE MALFORMED CEREBELLUM INDUCED BY PERINATAL INFECTION WITH THE FELINE PANLEUKOPENIA VIRUS (PLV) II. THE PURKINJE CELL AND ITS AFFERENTS

  1971cited by this paper

• GABAA receptor availability in clinical high-risk and first-episode psychosis: a [11C]Ro15-4513 positron emission tomography study

  2025cites this paper
• Neuroimaging studies of GABA in schizophrenia: a systematic review with meta-analysis

  2017cites this paper
• Aripiprazole Increases the PKA Signalling and Expression of the GABAA Receptor and CREB1 in the Nucleus Accumbens of Rats

  2016cites this paper
• In vivo measurement of GABA transmission in healthy subjects and schizophrenia patients.

  2015cites this paper
• GABA(A) receptor trafficking and localization in schizophrenia

  2015cites this paper
• Reduced binding potential of GABA-A/benzodiazepine receptors in individuals at ultra-high risk for psychosis: an [18F]-fluoroflumazenil positron emission tomography study.

  2014cites this paper
• Intracellular pathways of antipsychotic combined therapies: implication for psychiatric disorders treatment.

  2013cites this paper
• Alternations of NMDA and GABAB Receptor Function in Development: A Potential Animal Model of Schizophrenia

  2013cites this paper
• Glutamatergic gene expression is specifically reduced in thalamocortical projecting relay neurons in schizophrenia.

  2011cites this paper
• Effects of benzodiazepine treatment on cortical GABA(A) and muscarinic receptors: studies in schizophrenia and rats.

  2010cites this paper
• GABA concentration in schizophrenia patients and the effects of antipsychotic medication: a proton magnetic resonance spectroscopy study.

  2010influential citation
• Alterations of Neurotransmitter Receptors in Schizophrenia: Evidence from Postmortem Studies

  2009cites this paper
• Gene Association Studies of Schizophrenia and Tardive Dyskinesia

  2008cites this paper
• Family-based association study of lithium-related and other candidate genes in bipolar disorder.

  2008cites this paper
• Antipsychotic drug administration differentially affects [3H]muscimol and [3H]flunitrazepam GABA(A) receptor binding sites.

  2008cites this paper
• Antipsychotic Drugs: Comparison in Animal Models of Efficacy, Neurotransmitter Regulation, and Neuroprotection

  2008cites this paper
• The Role of GABAA Receptors in Schizophrenia

  2008cites this paper
• Heightened aggression after chronic flunitrazepam in male rats: potential links to cortical and caudate–putamen-binding sites

  2008cites this paper
• The effects of antipsychotic drugs on GABAA receptor binding depend on period of drug treatment and binding site examined.

  2007cites this paper
• Benzodiazepines and GABAergics in treating severe disabling tinnitus of predominantly cochlear origin.

  2006cites this paper
• Increased density of GABAA receptors in the superior temporal gyrus in schizophrenia

  2005cites this paper
• A Linkage Study Between the GABAA β2 and GABAAγ2 Subunit Genes and Major Psychoses

  2005cites this paper
• Changes in hippocampal GABAA receptor subunit composition in bipolar 1 disorder.

  2005cites this paper
• Interictal SPECT in patients with mesial temporal lobe epilepsy and psychosis: a case-control study.

  2005cites this paper
• Genetic investigation of chromosome 5q GABAA receptor subunit genes in schizophrenia

  2005cites this paper
• GABAA receptors: building the bridge between subunit mRNAs, their promoters, and cognate transcription factors.

  2004cites this paper
• Phencyclidine-induced changes in rat cortical gene expression identified by microarray analysis: implications for schizophrenia.

  2004cites this paper
• Perigenual cingulate gyrus volume in patients with schizophrenia: a magnetic resonance imaging study.

  2003cites this paper
• The effects of benzodiazepines on event-related potential indices of automatic and controlled processing in schizophrenia: a preliminary report.

  2002cites this paper
• Lack of normal structural asymmetry of the anterior cingulate gyrus in female patients with schizophrenia: a volumetric magnetic resonance imaging study.

  2002cites this paper
• [(3)H]Flumazenil binding in the human hippocampal formation, frontal cortex and cerebellum detected by high-resolution phosphorimaging.

  2002cites this paper
• The GABAergic system in schizophrenia.

  2002cites this paper
• GABAergic Interneurons: Implications for Understanding Schizophrenia and Bipolar Disorder

  2001cites this paper
• Schizophrenia: A review, with emphasis on the neurodevelopmental hypothesis

  2001cites this paper
• Emerging principles of altered neural circuitry in schizophrenia.

  2000cites this paper
• Signal Transmission, Rather Than Reception, is the Underlying Neurochemical Abnormality in Schizophrenia

  2000cites this paper
• Additivities of Compounds that Increase the Numbers of High Affinity [3H]Muscimol Binding Sites by Different Amounts Define More than 9 GABAA Receptor Complexes in Rat Forebrain: Implications for Schizophrenia and Clozapine Research

  2000cites this paper
• No Evidence of Altered In Vivo Benzodiazepine Receptor Binding in Schizophrenia

  1999cites this paper
• Evidence for altered trisynaptic circuitry in schizophrenic hippocampus.

  1999cites this paper
• Changes in serotonin2A and GABA(A) receptors in schizophrenia: studies on the human dorsolateral prefrontal cortex.

  1999cites this paper
• Neurochemical brain imaging investigations of schizophrenia.

  1999cites this paper
• The Predictive Value of Benzodiazepine Tolerance in Persistently Aggressive Schizophrenia

  1999cites this paper
• Comparison of the effects of dopamine D1 and D2 receptor antagonists on nerve growth factor mRNA expression.

  1999cites this paper
• [123I]Iomazenil SPECT benzodiazepine receptor imaging in schizophrenia.

  1999cites this paper
• Altered ratios of alternatively spliced long and short gamma2 subunit mRNAs of the gamma-amino butyrate type A receptor in prefrontal cortex of schizophrenics.

  1998cites this paper
• Model generation and testing to probe neural circuitry in the cingulate cortex of postmortem schizophrenic brain.

  1998cites this paper
• Cognitive functioning and GABAA/benzodiazepine receptor binding in schizophrenia: a 123I-iomazenil SPET study.

  1998cites this paper
• Oxidative reactions and schizophrenia: a review-discussion.

  1997cites this paper
• Schizophrenia, psychosis, and the basal ganglia.

  1997cites this paper
• Abnormal cholecystokinin mRNA levels in entorhinal cortex of schizophrenics.

  1997cites this paper
• Altered distribution of parvalbumin-immunoreactive local circuit neurons in the anterior cingulate cortex of schizophrenic patients.

  1997cites this paper
• Decreased anterior cingulate gyrus metabolic rate in schizophrenia.

  1997cites this paper
• Correlation between reduced in vivo benzodiazepine receptor binding and severity of psychotic symptoms in schizophrenia.

  1997cites this paper
• How a Poliovirus Might Cause Schizophrenia: A Commentary on Eagles' Hypothesis

  1997influential citation
• Benzodiazepine receptors in the post-mortem brain of suicide victims and schizophrenic subjects.

  1997cites this paper
• A two-process theory of schizophrenia: evidence from studies in post-mortem brain.

  1997cites this paper
• Uncoupling of GABA(A) and benzodiazepine receptor binding activity in the hippocampal formation of schizophrenic brain.

  1997cites this paper
• Benzodiazepine receptor distribution and diazepam binding in schizophrenia: an exploratory study.

  1997cites this paper
• The neuropathology of schizophrenia.

  1996cites this paper
• Neonatal Insult to the Hippocampal Region and Schizophrenia: A Review and a Putative Animal Model

  1996cites this paper
• Dopamine receptor gene expression in hippocampus is differentially regulated by the NMDA receptor antagonist MK-801.

  1996cites this paper
• Simple quantification of benzodiazepine receptor binding and ligand transport using iodine-123-iomazenil and two SPECT scans.

  1995cites this paper
• New Insights into the Biology of Schizophrenia through the Mechanism of Action of Clozapine

  1995cites this paper
• Glutamate receptor subtype expression in human postmortem brain tissue from schizophrenics and alcohol abusers.

  1995cites this paper
• Benzodiazepines and GABA hypothesis of schizophrenia

  1995cites this paper
• Decreased DOPAC in the anterior cingulate cortex of individuals with schizophrenia.

  1995cites this paper
• The phencyclidine-glutamate model of schizophrenia.

  1995cites this paper
• The N-methyl-d-aspartate antagonists phencyclidine, ketamine and dizocilpine as both behavioral and anatomical models of the dementias

  1995cites this paper
• Contributions of anterior cingulate cortex to behaviour.

  1995cites this paper
• GABAA receptor subunit gene expression in human prefrontal cortex: comparison of schizophrenics and controls.

  1995cites this paper
• [Current status of biochemical hypotheses in the pathogenesis of schizophrenia].

  1994cites this paper
• Developmentally moderated expressions of the neuropathology underlying schizophrenia.

  1994cites this paper
• SPECT measurement of benzodiazepine receptors in human brain with iodine-123-iomazenil: kinetic and equilibrium paradigms.

  1994cites this paper