Evaluation and improvement of the properties of the novel cystine-knot microprotein McoEeTI for oral administration.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  International journal of pharmaceutics

• Publication date

  2007-03-06

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/J.IJPHARM.2006.09.028PMID 17070661
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The potential of cystine-knot microproteins as novel pharmacophoric scaffolds in oral peptide drug delivery

  2006cited by this paper
• Barnase fusion as a tool to determine the crystal structure of the small disulfide-rich protein McoEeTI.

  2006cited by this paper
• Encyclopedia of Pharmaceutical Technology

  2006cited by this paper
• The use of thiolated polymers as carrier matrix in oral peptide delivery--proof of concept.

  2005cited by this paper
• A fusion protein system for the recombinant production of short disulfide bond rich cystine knot peptides using barnase as a purification handle.

  2005cited by this paper
• Thiolated chitosans: development and in vitro evaluation of a mucoadhesive, permeation enhancing oral drug delivery system.

  2004cited by this paper
• Thermal, chemical, and enzymatic stability of the cyclotide kalata B1: the importance of the cyclic cystine knot.

  2004cited by this paper
• Enhancement of Colonic Drug Absorption by the Paracellular Permeation Route

  2004cited by this paper
• Thiolated polymers--thiomers: synthesis and in vitro evaluation of chitosan-2-iminothiolane conjugates.

  2003cited by this paper
• Permeation enhancing polymers in oral delivery of hydrophilic macromolecules: thiomer/GSH systems.

  2003cited by this paper
• Improvement of the enzymatic stability of a cytotoxic T-lymphocyte-epitope model peptide for its oral administration.

  2002cited by this paper
• Multifunctional matrices for oral peptide delivery.

  2001cited by this paper
• The cystine knot motif in toxins and implications for drug design.

  2001cited by this paper
• Polycarbophil-cysteine conjugates as platforms for oral polypeptide delivery systems.

  2000cited by this paper
• In vitro evaluation of the permeation-enhancing effect of thiolated polycarbophil.

  2000cited by this paper
• The use of inhibitory agents to overcome the enzymatic barrier to perorally administered therapeutic peptides and proteins.

  1998cited by this paper
• Proteinase inhibitors induce selective stimulation of human trypsin and chymotrypsin secretion.

  1996cited by this paper
• Investigations into the Diffusion Behaviour of Polypeptides in Native Intestinal Mucus with Regard to their Peroral Administration

  1996cited by this paper
• Absorption-enhancing mechanism of sodium caprate and decanoylcarnitine in Caco-2 cells.

  1995cited by this paper
• Enzymatic barriers for GI peptide and protein delivery.

  1994cited by this paper
• Effect of organic acids, trypsin inhibitors and dietary protein on the pharmacological activity of recombinant human granulocyte colony-stimulating factor (rhG-CSF) in rats

  1992cited by this paper
• Enhancement of Colonic Drug Absorption by the Transcellular Permeation Route

  1988cited by this paper

• Design of Hepatitis C Protease Inhibitors Based on Knottin Fold

  2024cites this paper
• Enhancing Sensitivity of Nuclear Magnetic Resonance in Biomolecules: Parahydrogen-Induced Hyperpolarization in Synthetic Disulfide-Rich Miniproteins

  2024cites this paper
• Plant sources of bioactive peptides

  2021cites this paper
• Pharmacokinetic characterization of kalata B1 and related therapeutics built on the cyclotide scaffold.

  2019cites this paper
• Two metallocarboxypeptidase inhibitors are implicated in tomato fruit development and regulated by the Inner No Outer transcription factor.

  2018cites this paper
• Classes, Databases, and Prediction Methods of Pharmaceutically and Commercially Important Cystine-Stabilized Peptides

  2018cites this paper
• Biochemical characterization of the YBPCI miniprotein, the first carboxypeptidase inhibitor isolated from Yellow Bell Pepper (Capsicum annuum L). A novel contribution to the knowledge of miniproteins stability.

  2018cites this paper
• Peroral peptide delivery: Peptidase inhibition as a key concept for commercial drug products.

  2017cites this paper
• The Single Disulfide-Directed β-Hairpin Fold. Dynamics, Stability, and Engineering.

  2017cites this paper
• Structure-Based Monomerization of Human Serine Protease HTRA1 towards Evolutive Engineering of Activity Modulators

  2017cites this paper
• Orally Delivered Peptides for Treatment of Inflammatory Bowel Disease

  2017cites this paper
• Multivalent display of functional biomacromolecules: a modular approach

  2016cites this paper
• [Prospects for the design of new therapeutically significant protease inhibitors based on knottins and sunflower seed trypsin inhibitor (SFTI 1)].

  2016cites this paper
• Synthetic Cystine-Knot Miniproteins - Valuable Scaffolds for Polypeptide Engineering.

  2016cites this paper
• A cystine-knot miniprotein from tomato fruit inhibits endothelial cell migration and angiogenesis by affecting vascular endothelial growth factor receptor (VEGFR) activation and nitric oxide production.

  2015cites this paper
• Chemical and biological production of cyclotides.

  2015cites this paper
• Antimicrobial Peptides from Plants

  2015cites this paper
• Toxins and derivatives in molecular pharmaceutics: Drug delivery and targeted therapy.

  2015cites this paper
• The Cystine Knot Is Responsible for the Exceptional Stability of the Insecticidal Spider Toxin ω-Hexatoxin-Hv1a

  2015cites this paper
• High Proteolytic Resistance of Spider-Derived Inhibitor Cystine Knots

  2015cites this paper
• Disulphide-thiol chemistry: a multi-faceted tool for macromolecular design and synthesis of polyfunctional materials for specialized drug delivery.

  2015cites this paper
• Cystine‐knot peptides targeting cancer‐relevant human cytotoxic T lymphocyte‐associated antigen 4 (CTLA‐4)

  2015cites this paper
• De novo discovery of bioactive cyclic peptides using bacterial display and flow cytometry.

  2015cites this paper
• Protein Engineering an Cystinknoten-Miniproteinen: Generierung von immunregulatorischen Varianten mit optimierten Bindungseigenschaften und Gerüststrukturen

  2014cites this paper
• Fragmentation Follows Structure: Top-Down Mass Spectrometry Elucidates the Topology of Engineered Cystine-Knot Miniproteins

  2014cites this paper
• Potent and specific inhibition of the biological activity of the type-II transmembrane serine protease matriptase by the cyclic microprotein MCoTI-II

  2014cites this paper
• Intramolecular Thioether Crosslinking of Therapeutic Proteins to Increase Proteolytic Stability

  2014cites this paper
• Asteropsins B-D, sponge-derived knottins with potential utility as a novel scaffold for oral peptide drugs.

  2014cites this paper
• The Cyclic Cystine Ladder of Theta‐Defensins as a Stable, Bifunctional Scaffold: A Proof‐of‐Concept Study Using the Integrin‐Binding RGD Motif.

  2014cites this paper
• Solution structure of a sponge-derived cystine knot peptide and its notable stability.

  2014cites this paper
• Combinatorial Optimization of Cystine-Knot Peptides towards High-Affinity Inhibitors of Human Matriptase-1

  2013cites this paper
• Oxidative Folding of Peptides with Cystine‐Knot Architectures: Kinetic Studies and Optimization of Folding Conditions

  2013cites this paper
• Cyclotides as grafting frameworks for protein engineering and drug design applications.

  2013cites this paper
• Peptidic Inhibitors of Serine Proteinases of Plant Origin

  2013cites this paper
• scaffolds Engineering pro-angiogenic peptides using stable disulfide-rich cyclic

  2012cites this paper
• Do plant cyclotides have potential as immunosuppressant peptides?

  2012cites this paper
• Thiomers and thiomer-based nanoparticles in protein and DNA drug delivery

  2012cites this paper
• Importance of the cell membrane on the mechanism of action of cyclotides.

  2012cites this paper
• Engineering pro-angiogenic peptides using stable, disulfide-rich cyclic scaffolds.

  2011cites this paper
• Anti‐angiogenic effects of two cystine‐knot miniproteins from tomato fruit

  2011cites this paper
• Cyclotides: a patent review

  2011cites this paper
• Natural and engineered cystine knot miniproteins for diagnostic and therapeutic applications.

  2011cites this paper
• Bioactive cystine knot proteins.

  2011cites this paper
• Protease-resistant peptide ligands from a knottin scaffold library.

  2011cites this paper
• The Structure of Biological Therapeutics

  2010cites this paper
• Engineered cystine-knot miniproteins for diagnostic applications

  2010cites this paper
• Biological action of two tomato cysteine-rich miniproteins

  2010cites this paper
• 1 THE STRUCTURE OF BIOLOGICAL THERAPEUTICS

  2010cites this paper
• Biological diversity and therapeutic potential of natural and engineered cystine knot miniproteins.

  2009cites this paper
• Cyclotides: macrocyclic peptides with applications in drug design and agriculture

  2009cites this paper
• Polypeptide comprenant un fragment de protéine knottine

  2008cites this paper
• Alternative binding proteins: Biological activity and therapeutic potential of cystine‐knot miniproteins

  2008cites this paper
• Chemical and biomimetic total syntheses of natural and engineered MCoTI cyclotides.

  2008cites this paper
• Thiolated chitosans: useful excipients for oral drug delivery

  2008cites this paper
• The Therapeutic Potential of Cystine-Knot Microproteins

  2008cites this paper
• The cyclic cystine knot miniprotein MCoTI-II is internalized into cells by macropinocytosis.

  2007cites this paper