Werner syndrome protein associates with gamma H2AX in a manner that depends upon Nbs1.

No abstract is available for this paper.

• Publication year

  2005

• Venue

  FEBS Letters

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 15733840
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Linkage between Werner Syndrome Protein and the Mre11 Complex via Nbs1*

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• DNA end joining becomes less efficient and more error-prone during cellular senescence.

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• Physical Interaction between Replication Protein A and Rad51 Promotes Exchange on Single-stranded DNA*

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• Direct Activation of the ATM Protein Kinase by the Mre11/Rad50/Nbs1 Complex

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• Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks

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• Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumors.

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• DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

  2003cited by this paper
• ATM-related Tel1 associates with double-strand breaks through an Xrs2-dependent mechanism.

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• WRN Interacts Physically and Functionally with the Recombination Mediator Protein RAD52*

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• Bloom syndrome cells undergo p53-dependent apoptosis and delayed assembly of BRCA1 and NBS1 repair complexes at stalled replication forks

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• Requirement of the MRN complex for ATM activation by DNA damage

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• Gene expression profiling in Werner syndrome closely resembles that of normal aging

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• Werner Syndrome Protein Phosphorylation by Abl Tyrosine Kinase Regulates Its Activity and Distribution

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• H2AX haploinsufficiency modifies genomic stability and tumor susceptibility.

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• The Mre11 complex is required for ATM activation and the G2/M checkpoint

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• WRN helicase and FEN-1 form a complex upon replication arrest and together process branchmigrating DNA structures associated with the replication fork.

  2003cited by this paper
• RecQ helicases: caretakers of the genome

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• The MRE11 complex: at the crossroads of DNA repair and checkpoint signalling

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• Nbs1 is essential for DNA repair by homologous recombination in higher vertebrate cells

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• Genomic Instability in Mice Lacking Histone H2AX

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• Homologous Recombination Resolution Defect in Werner Syndrome

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• Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks.

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• Bloom's syndrome protein is required for correct relocalization of RAD50/MRE11/NBS1 complex after replication fork arrest

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• A murine model of Nijmegen breakage syndrome.

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• Werner Protein Is a Target of DNA-dependent Protein Kinase in Vivo and in Vitro, and Its Catalytic Activities Are Regulated by Phosphorylation*

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• Lack of WRN results in extensive deletion at nonhomologous joining ends.

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• Colocalization, Physical, and Functional Interaction between Werner and Bloom Syndrome Proteins*

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• NBS1 localizes to gamma-H2AX foci through interaction with the FHA/BRCT domain.

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• Chromosomal stability and the DNA double-stranded break connection

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• Werner syndrome cells are sensitive to DNA cross‐linking drugs

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• DNA Damage-Dependent Nuclear Dynamics of the Mre11 Complex

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• Werner syndrome protein is regulated and phosphorylated by DNA-dependent protein kinase.

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• Werner helicase relocates into nuclear foci in response to DNA damaging agents and co‐localizes with RPA and Rad51

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• A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage.

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• ATM-dependent phosphorylation of nibrin in response to radiation exposure

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• Ku complex interacts with and stimulates the Werner protein.

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• Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products

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• A role for Saccharomyces cerevisiae histone H2A in DNA repair

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• Werner's syndrome protein (WRN) migrates Holliday junctions and co‐localizes with RPA upon replication arrest

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• Enzymatic and DNA binding properties of purified WRN protein: high affinity binding to single-stranded DNA but not to DNA damage induced by 4NQO.

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• Megabase Chromatin Domains Involved in DNA Double-Strand Breaks in Vivo

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• Functional and Physical Interaction between WRN Helicase and Human Replication Protein A*

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• Reduction of Werner Syndrome Protein Enhances G:C → A:T Transition by O6-Methylguanine in Human Cells.

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• Localization of the Werner Protein Together with H2AX in γ-Irradiation-Induced Neoplastic Transformed Human Mesenchymal Stem Cells.

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• Human RecQ helicases in DNA repair, recombination, and replication.

  2014cites this paper
• Comprehensive analysis of WRN protein interaction network by Mass Spectrometry.

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• Nonenzymatic role for WRN in preserving nascent DNA strands after replication stress.

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• Polymorphisms in DNA repair pathway genes, body mass index, and risk of non‐Hodgkin lymphoma

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• Benzo[a]pyrene induces complex H2AX phosphorylation patterns by multiple kinases including ATM, ATR, and DNA-PK.

  2011cites this paper
• WRN participates in translesion synthesis pathway through interaction with NBS1.

  2010cites this paper
• The Caenorhabditis elegans Werner Syndrome Protein Functions Upstream of ATR and ATM in Response to DNA Replication Inhibition and Double-Strand DNA Breaks

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• Werner syndrome protein, WRN, protects cells from DNA damage induced by the benzene metabolite hydroquinone.

  2009cites this paper
• Choreography of recombination proteins during the DNA damage response.

  2009cites this paper
• Rôle de protéines de la réparation des cassures double brin dans l'homéostasie télomérique chez Arabidopsis thaliana

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• WRN is required for ATM activation and the S-phase checkpoint in response to interstrand cross-link-induced DNA double-strand breaks.

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• Identification of the Xenopus DNA2 protein as a major nuclease for the 5′→3′ strand-specific processing of DNA ends

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• Depletion of WRN enhances DNA damage in HeLa cells exposed to the benzene metabolite, hydroquinone.

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• From old organisms to new molecules: integrative biology and therapeutic targets in accelerated human ageing

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• Molecular Chaperones and the Epigenetics of Longevity and Cancer Resistance

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• Werner syndrome protein prevents DNA breaks upon chromatin structure alteration

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• Two roles for Rad 50 in telomere maintenance

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• Two roles for Rad50 in telomere maintenance

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• Werner syndrome: molecular insights into the relationships between defective DNA metabolism, genomic instability, cancer and aging.

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• Genetic analysis of chromosome pairing, recombination, and cell cycle control during first meiotic prophase in mammals.

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• Collaboration of Werner syndrome protein and BRCA1 in cellular responses to DNA interstrand cross-links

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• Role des histone variants dans la dynamique de la chromatine

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• Gene expression and DNA repair in progeroid syndromes and human aging.

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