De Novo Pyrimidine Nucleotide Synthesis Mainly Occurs outside of Plastids, but a Previously Undiscovered Nucleobase Importer Provides Substrates for the Essential Salvage Pathway in Arabidopsis[W]

No abstract is available for this paper.

• Publication year

  2012

• Venue

  The Plant Cell

• Publication date

  2012-04-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1105/tpc.112.096743PMID 22474184PMCID PMC3398563
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The biochemistry of nitrogen mobilization: purine ring catabolism.

  2011cited by this paper
• A plastidial sodium-dependent pyruvate transporter

  2011cited by this paper
• A plastidial sodium-dependent pyruvate transporter

  2011cited by this paper
• Pyrimidine degradation influences germination seedling growth and production of Arabidopsis seeds

  2011influential reference
• Arabidopsis thaliana nucleosidase mutants provide new insights into nucleoside degradation

  2011cited by this paper
• Arabidopsis nucleoside hydrolases involved in intracellular and extracellular degradation of purines.

  2011cited by this paper
• Uptake of AMP, ADP, and ATP in Escherichia coli W

  2011cited by this paper
• Plastid Uridine Salvage Activity Is Required for Photoassimilate Allocation and Partitioning in Arabidopsis[C][W]

  2011cited by this paper
• Regulation of CPSase, ACTase, and OCTase genes in Medicago truncatula: Implications for carbamoylphosphate synthesis and allocation to pyrimidine and arginine de novo biosynthesis.

  2010cited by this paper
• Nucleoside transport and associated metabolism.

  2010influential reference
• The central regulation of plant physiology by adenylates.

  2010cited by this paper
• Uracil salvage is necessary for early Arabidopsis development.

  2009influential reference
• Uridine-Ribohydrolase Is a Key Regulator in the Uridine Degradation Pathway of Arabidopsis[W]

  2009influential reference
• A functional analysis of the pyrimidine catabolic pathway in Arabidopsis

  2009influential reference
• Structure and Molecular Mechanism of a Nucleobase–Cation–Symport-1 Family Transporter

  2008cited by this paper
• Expression and functional analysis of aspartate transcarbamoylase and role of de novo pyrimidine synthesis in regulation of growth and development in Arabidopsis.

  2008cited by this paper
• Characterization of the Arabidopsis Brittle1 transport protein and impact of reduced activity on plant metabolism.

  2008cited by this paper
• The Transporter Classification Database: recent advances

  2008influential reference
• Arabidopsis mesophyll protoplasts: a versatile cell system for transient gene expression analysis

  2007influential reference
• Imaging the actin cytoskeleton in growing pollen tubes

  2006cited by this paper
• Pyrimidine and purine biosynthesis and degradation in plants.

  2006cited by this paper
• Identification and Characterization of a Novel Plastidic Adenine Nucleotide Uniporter from Solanum tuberosum*

  2005cited by this paper
• Solute transporters of the plastid envelope membrane.

  2005cited by this paper
• Functional Analysis of the Pyrimidine de Novo Synthesis Pathway in Solanaceous Species1

  2005cited by this paper
• Genes, enzymes and regulation of arginine biosynthesis in plants.

  2005influential reference
• GENEVESTIGATOR. Arabidopsis Microarray Database and Analysis Toolbox1[w]

  2004cited by this paper
• Alterations in pyrimidine nucleotide metabolism as an early signal during the execution of programmed cell death in tobacco BY-2 cells.

  2004cited by this paper
• Regulation of pyrimidine metabolism in plants.

  2004cited by this paper
• The Arabidopsis mutant dct is deficient in the plastidic glutamate/malate translocator DiT2.

  2003cited by this paper
• ARAMEMNON, a Novel Database for Arabidopsis Integral Membrane Proteins1

  2003influential reference
• Plant dihydroorotate dehydrogenase differs significantly in substrate specificity and inhibition from the animal enzymes

  2002cited by this paper
• Saccharomyces cerevisiae URH1 (Encoding Uridine-Cytidine N-Ribohydrolase): Functional Complementation by a Nucleoside Hydrolase from a Protozoan Parasite and by a Mammalian Uridine Phosphorylase

  2002cited by this paper
• The antiquity of RNA-based evolution

  2002cited by this paper
• Adenine phosphoribosyltransferase isoforms of Arabidopsis and their potential contributions to adenine and cytokinin metabolism.

  2002influential reference
• ChloroP, a neural network‐based method for predicting chloroplast transit peptides and their cleavage sites

  1999cited by this paper
• A GFP-mouse talin fusion protein labels plant actin filaments in vivo and visualizes the actin cytoskeleton in growing pollen tubes.

  1998cited by this paper
• Characterization of a novel eukaryotic ATP/ADP translocator located in the plastid envelope of Arabidopsis thaliana L.

  1997cited by this paper
• CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice.

  1994influential reference
• Interaction between fatty-acid and starch synthesis in isolated amyloplasts from cauliflower floral buds

  1994cited by this paper
• Characterization of Glucose-6-Phosphate Incorporation into Starch by Isolated Intact Cauliflower-Bud Plastids

  1993influential reference
• Transport Processes and Corresponding Changes in Metabolite Levels in Relation to Starch Synthesis in Barley (Hordeum vulgare L.) Etioplasts.

  1992cited by this paper
• Cis and trans-acting elements involved in the activation of Arabidopsis thaliana A1 gene encoding the translation elongation factor EF-1 alpha.

  1991cited by this paper
• Cis and trans-acting elements involved in the activation of Arabidopsis thaliana Al gene encoding the translation elongation factor EF-lα

  1991cited by this paper
• Primary structure of the uracil transport protein of Saccharomyces cerevisiae.

  1988cited by this paper
• Localization of carbamoylphosphate synthetase and aspartate carbamoyltransferase in chloroplasts.

  1986cited by this paper
• Enzymic capacities of purified cauliflower bud plastids for lipid synthesis and carbohydrate metabolism.

  1985cited by this paper
• Expression of the cloned uracil permease gene of Saccharomyces cerevisiae in a heterologous membrane.

  1982cited by this paper
• A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

  1976cited by this paper
• The inner membrane of the chloroplast envelope as the site of specific metabolite transport.

  1971cited by this paper

• Anti-Toxoplasma activity of NBMPR is mediated through the inhibition of nucleoside and nucleobase transporters

  2026cites this paper
• Three Arabidopsis UMP kinases have different roles in pyrimidine nucleotide biosynthesis and (deoxy)CMP salvage.

  2024cites this paper
• Nucleotide limitation results in impaired photosynthesis, reduced growth and seed yield together with massively altered gene expression.

  2023cites this paper
• Transcriptional reprogramming of nucleotide metabolism in response to altered pyrimidine availability in Arabidopsis seedlings

  2023cites this paper
• New Insights into rice pyrimidine catabolic enzymes

  2023cites this paper
• A plastid nucleoside kinase is involved in inosine salvage and control of purine nucleotide biosynthesis.

  2022cites this paper
• Cytidine Triphosphate Synthase Four From Arabidopsis thaliana Attenuates Drought Stress Effects

  2022cites this paper
• l-Aspartate: An Essential Metabolite for Plant Growth and Stress Acclimation

  2021cites this paper
• Cytosolic CTP Production Limits the Establishment of Photosynthesis in Arabidopsis

  2021cites this paper
• The genome of the gymnosperm Picea glauca encodes a single Nucleobase Cation Symporter 1 (PgNCS1) that displays a broad yet unique solute specificity profile

  2021cites this paper
• CTP Synthase 2 From Arabidopsis thaliana Is Required for Complete Embryo Development

  2021cites this paper
• Mechanisms of feedback inhibition and sequential firing of active sites in plant aspartate transcarbamoylase

  2021cites this paper
• Metabolic Labeling of RNAs Uncovers Hidden Features and Dynamics of the Arabidopsis Transcriptome[CC-BY]

  2020cites this paper
• TOR coordinates nucleotide availability with ribosome biogenesis in plants

  2020cites this paper
• Of clocks and coenzymes in plants: intimately connected cycles guiding central metabolism?

  2020cites this paper
• Growth and development

  2020cites this paper
• UMP inhibition and sequential firing in aspartate transcarbamoylase open ways to regulate plant growth

  2020cites this paper
• Apple nucleobase cation symporter 1 transports guanine and the toxic guanine analog 6-thioguanine

  2020cites this paper
• The coenzyme thiamine diphosphate displays a daily rhythm in the Arabidopsis nucleus

  2020cites this paper
• The Nicotiana sylvestris nucleobase cation symporter 1 retains a dicot solute specificity profile

  2020cites this paper
• A Kinase and a Glycosylase Catabolize Pseudouridine in the Peroxisome to Prevent Toxic Pseudouridine Monophosphate Accumulation

  2020cites this paper
• The plastidial pentose phosphate pathway is essential for postglobular embryo development in Arabidopsis

  2019cites this paper
• Metabolic labeling of RNAs uncovers hidden features and dynamics of the Arabidopsis thaliana transcriptome

  2019cites this paper
• Pyrimidine Salvage: Physiological Functions and Interaction with Chloroplast Biogenesis1

  2019cites this paper
• Phytophthora infestans Dihydroorotate Dehydrogenase Is a Potential Target for Chemical Control – A Comparison With the Enzyme From Solanum tuberosum

  2019cites this paper
• Nucleotide Metabolism in Plants1[OPEN]

  2019influential citation
• Nucleotide Transport and Metabolism in Diatoms

  2019cites this paper
• Identification of Chloroplast Envelope Proteins with Critical Importance for Cold Acclimation1[OPEN]

  2019cites this paper
• The PLUTO plastidial nucleobase transporter also transports the thiamin precursor hydroxymethylpyrimidine

  2018cites this paper
• Genome-wide DNA Methylation analysis in response to salinity in the model plant caliph medic (Medicago truncatula)

  2018cites this paper
• Efficient Replication of the Plastid Genome Requires an Organellar Thymidine Kinase1[OPEN]

  2018cites this paper
• Role of pyrimidine salvage pathway in the maintenance of organellar and nuclear genome integrity

  2018cites this paper
• Cryptic purine transporters in Aspergillus nidulans reveal the role of specific residues in the evolution of specificity in the NCS1 family

  2017cites this paper
• Shuttling of (deoxy-) purine nucleotides between compartments of the diatom Phaeodactylum tricornutum.

  2017cites this paper
• Microsporidia: Why Make Nucleotides if You Can Steal Them?

  2016cites this paper
• Heterologous complementation studies reveal the solute transport profiles of a two-member nucleobase cation symporter 1 (NCS1) family in Physcomitrella patens.

  2016cites this paper
• Comprehensive genomic identification and expression analysis of the nucleobase-ascorbate transporter (NAT) gene family in apple

  2016cites this paper
• The solute specificity profiles of nucleobase cation symporter 1 (NCS1) from Zea mays and Setaria viridis illustrate functional flexibility

  2016influential citation
• Early signaling, synthesis, transport and metabolism of ureides.

  2016cites this paper
• Origin, diversification and substrate specificity in the family of NCS1/FUR transporters

  2015cites this paper
• Structure-Function Relationship of a Plant NCS1 Member – Homology Modeling and Mutagenesis Identified Residues Critical for Substrate Specificity of PLUTO, a Nucleobase Transporter from Arabidopsis

  2014cites this paper
• Paulinella chromatophora – rethinking the transition from endosymbiont to organelle

  2014cites this paper
• Cellular serpents and dreaming spires: new frontiers in arginine and pyrimidine biology.

  2014cites this paper
• Biochemical characterization and structure-function relationship of two plant NCS2 proteins, the nucleobase transporters NAT3 and NAT12 from Arabidopsis thaliana.

  2014cites this paper
• Molecular mechanism of ligand recognition by membrane transport protein, Mhp1

  2014cites this paper
• Nucleobase and nucleoside transport and integration into plant metabolism

  2014influential citation
• Unknown components of the plastidial permeome

  2014influential citation
• Comparative proteomic analysis of early salt stress responsive proteins in roots and leaves of rice

  2014cites this paper
• The nucleobase cation symporter 1 of Chlamydomonas reinhardtii and that of the evolutionarily distant Arabidopsis thaliana display parallel function and establish a plant-specific solute transport profile.

  2013cites this paper
• Two thymidine kinases and one multisubstrate deoxyribonucleoside kinase salvage DNA precursors in Arabidopsis thaliana

  2012cites this paper
• Metabolic integration of the chloroplast during endosymbiosis - molecular characterization of envelope transport proteins

  2012cites this paper
• Mini Review Article

  year unknowncites this paper