The notch pathway positively regulates programmed cell death during erythroid differentiation

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Leukemia

• Publication date

  2007-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/sj.leu.2404705PMID 17476283
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Distinct roles of Mdm2 and Mdm4 in red cell production.

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• Notch signalling: a simple pathway becomes complex

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• The myeloproliferative disorders.

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• Gamma secretase inhibitor blocks Notch activation and induces apoptosis in Kaposi's sarcoma tumor cells

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• Notch signaling is a potent inducer of growth arrest and apoptosis in a wide range of B-cell malignancies.

  2005cited by this paper
• RBPjκ-dependent Notch function regulates Gata2 and is essential for the formation of intra-embryonic hematopoietic cells

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• Hedgehog signaling is required for adult blood stem cell formation in zebrafish embryos.

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• Expression of Notch-1 and its ligands, Delta-like-1 and Jagged-1, is critical for glioma cell survival and proliferation.

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• Notch Signals Inhibit the Development of Erythroid/Megakaryocytic Cells by Suppressing GATA-1 Activity through the Induction of HES1*

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• Hematopoietic stem cell fate is established by the Notch-Runx pathway.

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• Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants.

  2004cited by this paper
• Notch activation induces apoptosis in neural progenitor cells through a p53-dependent pathway.

  2004cited by this paper
• Notch‐1 regulates cell death independently of differentiation in murine erythroleukemia cells through multiple apoptosis and cell cycle pathways

  2004cited by this paper
• Notch4 Inhibits Endothelial Apoptosis via RBP-Jκ-dependent and -independent Pathways*

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• Identification of p53 regulators by genome-wide functional analysis.

  2004cited by this paper
• Notch signaling: control of cell communication and cell fate

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• The onset of p53-dependent apoptosis plays a role in terminal differentiation of human normoblasts

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• Notch1 but not Notch2 is essential for generating hematopoietic stem cells from endothelial cells.

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• Notch1 signaling inhibits growth of human hepatocellular carcinoma through induction of cell cycle arrest and apoptosis.

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• Notch1 enhances B-cell receptor-induced apoptosis in mature activated B cells without affecting cell cycle progression and surface IgM expression

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• Oncogenes and Tumor Suppressors (795 articles) Signal Transduction (1930 articles)

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• The regulation of apoptosis by Numb/Notch signaling in the serotonin lineage of Drosophila

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• The p53 tumour suppressor inhibits glucocorticoid‐induced proliferation of erythroid progenitors

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• Activated Notch1 signaling promotes tumor cell proliferation and survival in Hodgkin and anaplastic large cell lymphoma.

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• Apoptosis protection by the Epo target Bcl-X(L) allows factor-independent differentiation of primary erythroblasts.

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• Targeting c-kit mutations in solid tumors: scientific rationale and novel therapeutic options.

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• Identification of myelodysplastic syndrome-specific genes by DNA microarray analysis with purified hematopoietic stem cell fraction.

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• Ineffective erythropoiesis in Stat5a(-/-)5b(-/-) mice due to decreased survival of early erythroblasts.

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• Monocytes express high amounts of Notch and undergo cytokine specific apoptosis following interaction with the Notch ligand, Delta-1.

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• Suppression of Erythroid but Not Megakaryocytic Differentiation of Human K562 Erythroleukemic Cells by Notch-1*

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• Notch signaling is essential for vascular morphogenesis in mice.

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• Development of erythroid and myeloid progenitors in the yolk sac and embryo proper of the mouse.

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• Embryonic lethality and vascular defects in mice lacking the Notch ligand Jagged1.

  1999cited by this paper
• Notch‐1 inhibits apoptosis in murine erythroleukemia cells and is necessary for differentiation induced by hybrid polar compounds

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• bcl-x Prevents Apoptotic Cell Death of Both Primitive and Definitive Erythrocytes at the End of Maturation

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• Cutting edge: protective effects of notch-1 on TCR-induced apoptosis.

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• The human homolog of rat Jagged1 expressed by marrow stroma inhibits differentiation of 32D cells through interaction with Notch1.

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  1998cited by this paper
• Local induction of patterning and programmed cell death in the developing Drosophila retina.

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• Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

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• Erythropoietin can promote erythroid progenitor survival by repressing apoptosis through Bcl-XL and Bcl-2.

  1996cited by this paper
• Transcription factor GATA-1 permits survival and maturation of erythroid precursors by preventing apoptosis.

  1995cited by this paper
• Disruption of the mouse RBP-J kappa gene results in early embryonic death.

  1995cited by this paper
• Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice

  1995cited by this paper
• Apoptosis and hematopoiesis in murine fetal liver.

  1993cited by this paper
• Signal transduction through the receptor for erythropoietin.

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• Control of red cell production: the roles of programmed cell death (apoptosis) and erythropoietin

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• Flow cytometric analysis of human bone marrow: I. Normal erythroid development.

  1987cited by this paper
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• B1 lymphocytes develop independently of Notch signaling during mouse embryonic development

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• B-1 lymphoid cells develop independently of Notch signaling during mouse embryonic development

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• A systems biology pipeline identifies regulatory networks for stem cell engineering

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• Notch and Stem Cells.

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• Notch Ligands in Hematopoietic Stem Cell Production

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• NUMB inactivation confers resistance to imatinib in chronic myeloid leukemia cells.

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• Running title: Nutlin-3 upregulates Notch1 expression

  2016cites this paper
• Université de Montréal-Thèse numérique

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• Complex regulation of HSC emergence by the Notch signaling pathway.

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• HEMATOPOIESIS AND STEM CELLS Notch 1 acts via Foxc 2 to promote de fi nitive hematopoiesis via effects on hemogenic endothelium

  2015cites this paper
• Notch1 acts via Foxc2 to promote definitive hematopoiesis via effects on hemogenic endothelium.

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• Influence of Jagged1 on apoptosis-related gene expression: a microarray database analysis

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• Identification of Cdca7 as a novel Notch transcriptional target involved in hematopoietic stem cell emergence

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• Notch1 regulates progenitor cell proliferation and differentiation during mouse yolk sac hematopoiesis

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• Molecular cross talk between Notch1, Shh and Akt pathways during erythroid differentiation of K562 and HEL cell lines.

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• A Correction to the Research Article Titled "Direct Response to Notch Activation: Signaling Crosstalk and Incoherent Logic" by A. Krejčí, F. Bernard, B. Housden, S. Collins, S. J. Bray

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