Cancer vaccination: manipulation of immune responses at old age.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Mechanisms of Ageing and Development

• Publication date

  Unknown publication date

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/j.mad.2008.05.003PMID 18561984
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1987cited by this paper
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  year unknowncited by this paper

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