A haplotype containing the p53 polymorphisms Ins16bp and Arg72Pro modifies cancer risk in BRCA2 mutation carriers

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Human Mutation

• Publication date

  2006-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/humu.20283PMID 16419081
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1999cited by this paper
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  1998cited by this paper
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  1997cited by this paper
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  1997influential reference
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  1996cited by this paper
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  1995influential reference
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  1995influential reference
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  1995cited by this paper
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  1995cited by this paper
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  1993cited by this paper

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