Ferulic acid reverses the cognitive dysfunction caused by amyloid β peptide 1-40 through anti-oxidant activity and cholinergic activation in rats.

No abstract is available for this paper.

• Publication year

  2015

• Venue

  The American Journal of Chinese Medicine

• Publication date

  2015-04-17

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1142/S0192415X15500214PMID 25807957
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• [Acetylcholinesterase inhibitors for treatment of Alzheimer's disease].

  2014influential reference
• Bushen-Yizhi formula ameliorates cognition deficits and attenuates oxidative stress-related neuronal apoptosis in scopolamine-induced senescence in mice

  2014cited by this paper
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  2014influential reference
• Ethanol extract of Astragali Radix and Salviae Miltiorrhizae Radix, Myelophil, exerts anti-amnesic effect in a mouse model of scopolamine-induced memory deficits.

  2014cited by this paper
• Transient disturbances in contextual fear memory induced by Aβ(25-35) in rats are accompanied by cholinergic dysfunction.

  2014cited by this paper
• High-dose of vitamin C supplementation reduces amyloid plaque burden and ameliorates pathological changes in the brain of 5XFAD mice

  2014cited by this paper
• Effect of vitamin E and memantine on functional decline in Alzheimer disease: the TEAM-AD VA cooperative randomized trial.

  2014cited by this paper
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  2013cited by this paper
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  2013cited by this paper
• The Possible Role of Antioxidant Vitamin C in Alzheimer’s Disease Treatment and Prevention

  2013influential reference
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  2012cited by this paper
• Traditional Chinese Medicine for Senile Dementia

  2011cited by this paper
• Beneficial effects of resveratrol on scopolamine but not mecamylamine induced memory impairment in the passive avoidance and Morris water maze tests in rats.

  2011influential reference
• The Ameliorating Effects of Luteolin on Beta-Amyloid-Induced Impairment of Water Maze Performance and Passive Avoidance in Rats

  2010influential reference
• The ameliorating effects of luteolin on beta-amyloid-induced impairment of water maze performance and passive avoidance in rats.

  2010cited by this paper
• Ferulic acid attenuated cognitive deficits and increase in carbonyl proteins induced by buthionine-sulfoximine in mice.

  2008cited by this paper
• Effects of luteolin on learning acquisition in rats: involvement of the central cholinergic system.

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  2005cited by this paper
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  2005influential reference
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  2004cited by this paper
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  2002influential reference
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  2001influential reference
• Radix Angelica Sinensis extracts ameliorate scopolamine- and cycloheximide-induced amnesia, but not p-chloroamphetamine-induced amnesia in rats.

  2000cited by this paper
• Inflammation of the brain in Alzheimer's disease: implications for therapy

  1999influential reference
• Improvement by nefiracetam of β‐amyloid‐(1‐42)‐induced learning and memory impairments in rats

  1999cited by this paper
• Ameliorating effect of p-hydroxybenzyl alcohol on cycloheximide-induced impairment of passive avoidance response in rats: interactions with compounds acting at 5-HT1A and 5-HT2 receptors.

  1998cited by this paper
• Effect of long-term administration of berberine on scopolamine-induced amnesia in rats.

  1997cited by this paper
• Effects of Gastrodia elata and its active constituents on scopolamine-induced amnesia in rats.

  1996cited by this paper
• Memory impairment and neuronal dysfunction induced by beta-amyloid protein in rats.

  1994influential reference
• β-Amyloid protein-induced Alzheimer's disease animal model

  1994influential reference
• The cholinergic hypothesis of Alzheimer's disease

  1993cited by this paper
• Long-term central cholinergic hypofunction induced in mice by ethylcholine aziridinium ion (AF64A) in vivo.

  1982cited by this paper
• Differential effects of scopolamine and mecamylamine on passive avoidance behavior.

  1972influential reference
• Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein).

  1969cited by this paper
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  1961cited by this paper

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