On the karyotypic origin and evolution of cancer cells.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Cancer Genetics and Cytogenetics

• Publication date

  2009-10-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.cancergencyto.2009.06.008PMID 19781442
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The chromosomes of forty-two primary Rous sarcomas of the Chinese hamster.

  2009cited by this paper
• Cancer-causing karyotypes: chromosomal equilibria between destabilizing aneuploidy and stabilizing selection for oncogenic function.

  2009influential reference
• Clonal selection in malignant transformation of human fibroblasts transduced with defined cellular oncogenes.

  2008influential reference
• Specific clones of spontaneously evolving karyotypes generate individuality of cancers.

  2008influential reference
• Defining the steps that lead to cancer: replicative telomere erosion, aneuploidy and an epigenetic maturation arrest of tissue stem cells.

  2008cited by this paper
• Concerning the Origin of Malignant Tumours by Theodor Boveri. Translated and annotated by Henry Harris

  2008cited by this paper
• Aneuploidy: Cells Losing Their Balance

  2008cited by this paper
• Concerning the Origin of Malignant Tumours

  2008cited by this paper
• Mad2 overexpression promotes aneuploidy and tumorigenesis in mice.

  2007cited by this paper
• Genomic imbalances in 5918 malignant epithelial tumors: an explorative meta-analysis of chromosomal CGH data

  2007cited by this paper
• The Genomic Landscapes of Human Breast and Colorectal Cancers

  2007cited by this paper
• Cancer drug resistance: the central role of the karyotype.

  2007cited by this paper
• Aneuploidy acts both oncogenically and as a tumor suppressor.

  2007cited by this paper
• Chromosomal chaos and cancer.

  2007cited by this paper
• Aneuploidy and cancer: from correlation to causation.

  2006cited by this paper
• Relationship of gene expression and chromosomal abnormalities in colorectal cancer.

  2006cited by this paper
• Does aneuploidy cause cancer?

  2006cited by this paper
• Gene expression profiling: cell cycle deregulation and aneuploidy do not cause breast cancer formation in WAP-SVT/t transgenic animals

  2005cited by this paper
• Chromosomal alterations cause the high rates and wide ranges of drug resistance in cancer cells.

  2005influential reference
• A network of genetic events sufficient to convert normal human cells to a tumorigenic state.

  2005cited by this paper
• The Chromosomal Basis of Cancer

  2005cited by this paper
• Oncogene addiction: sometimes a temporary slavery.

  2004cited by this paper
• Aneuploidy, the Primary Cause of the Multilateral Genomic Instability of Neoplastic and Preneoplastic Cells

  2004cited by this paper
• Chromosome Transfer Induced Aneuploidy Results in Complex Dysregulation of the Cellular Transcriptome in Immortalized and Cancer Cells

  2004cited by this paper
• Multistep Carcinogenesis: A Chain Reaction of Aneuploidizations

  2003cited by this paper
• Instability of chromosome structure in cancer cells increases exponentially with degrees of aneuploidy.

  2003cited by this paper
• Refractory nature of normal human diploid fibroblasts with respect to oncogene-mediated transformation

  2003cited by this paper
• Are cancers dependent on oncogenes or on aneuploidy?

  2003cited by this paper
• Untangling the roots of cancer.

  2003cited by this paper
• A new method for improving metaphase chromosome spreading

  2003cited by this paper
• Microarray analysis reveals a major direct role of DNA copy number alteration in the transcriptional program of human breast tumors

  2002cited by this paper
• Felix Mitelman: Database of chromosome aberrations in cancer

  2002cited by this paper
• Correspondence re: D. Zimonjic et al., Derivation of human tumor cells in vitro without widespread genomic instability. Cancer Res., 61: 8838-8844, 2001.

  2002cited by this paper
• Debate Surges Over the Origins of Genomic Defects in Cancer

  2002influential reference
• Origin of multidrug resistance in cells with and without multidrug resistance genes: Chromosome reassortments catalyzed by aneuploidy

  2001cited by this paper
• Derivation of human tumor cells in vitro without widespread genomic instability.

  2001cited by this paper
• Stromal and Epithelial Expression of Tumor Markers Hyaluronic Acid and HYAL1 Hyaluronidase in Prostate Cancer*

  2001cited by this paper
• Aneuploidy, the somatic mutation that makes cancer a species of its own.

  2000cited by this paper
• Aneuploidy precedes and segregates with chemical carcinogenesis.

  2000cited by this paper
• Systematic variation in gene expression patterns in human cancer cell lines

  2000cited by this paper
• Explaining the high mutation rates of cancer cells to drug and multidrug resistance by chromosome reassortments that are catalyzed by aneuploidy.

  2000cited by this paper
• Aneuploidy vs. gene mutation hypothesis of cancer: recent study claims mutation but is found to support aneuploidy.

  2000cited by this paper
• Patterns of genomic imbalances in human solid tumors (Review).

  2000cited by this paper
• The promise of comparative genomics in mammals.

  1999cited by this paper
• Creation of human tumour cells with defined genetic elements

  1999influential reference
• Patterns of chromosomal imbalances in advanced urinary bladder cancer detected by comparative genomic hybridization.

  1998cited by this paper
• Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization.

  1998cited by this paper
• Cancer genetics and cytogenetics

  1998cited by this paper
• Genetic instability of cancer cells is proportional to their degree of aneuploidy.

  1998cited by this paper
• The cells of the body: a history of somatic cell genetics

  1997cited by this paper
• Time-Sensitive Reversal of Hyperplasia in Transgenic Mice Expressing SV40 T Antigen

  1996cited by this paper
• The multistep nature of cancer.

  1993cited by this paper
• SV40 T antigen induced chromosomal changes reflect a process that is both clastogenic and aneuploidogenic and is ongoing throughout neoplastic progression of human fibroblasts.

  1992cited by this paper
• Expression of SV40 large T antigen, but not small t antigen, is required for the induction of chromosomal aberrations in transformed human cells.

  1991cited by this paper
• Introduction of the activated N-ras oncogene into human fibroblasts by retroviral vector induces morphological transformation and tumorigenicity.

  1990cited by this paper
• Chromosome abnormalities in human reproductive wastage

  1986cited by this paper
• Cytogenetic heterogeneity: its role in tumor evolution.

  1986cited by this paper
• Chemically induced aneuploidy in mammalian cells: mechanisms and biological significance in cancer.

  1986cited by this paper
• The Consequences of Chromosome Imbalance: Principles, Mechanisms, and Models

  1986cited by this paper
• A case for human tumor‐suppressor genes

  1985cited by this paper
• Tumor heterogeneity.

  1984cited by this paper
• Down syndrome--a disruption of homeostasis.

  1983cited by this paper
• Relative difficulties in transforming human and animal cells in vitro.

  1983cited by this paper
• The Chromosomes in Human Cancer and Leukemia

  1981cited by this paper
• Cancer—Science and Society

  1980cited by this paper
• Fundamentals of Oncology

  1979cited by this paper
• Neoplastic development

  1976cited by this paper
• The clonal evolution of tumor cell populations.

  1976cited by this paper
• The Role of Chromosomes in Cancer Biology

  1973cited by this paper
• The molecular biology of tumour viruses

  1973cited by this paper
• Science and Society

  1969cited by this paper
• Multiple etiologic factors in neoplastic development.

  1965cited by this paper
• THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS.

  1965cited by this paper
• AGAR SUSPENSION CULTURE FOR THE SELECTIVE ASSAY OF CELLS TRANSFORMED BY POLYOMA VIRUS.

  1964cited by this paper
• ANEUPLOIDY IN THE DEGENERATIVE PHASE OF SERIAL CULTIVATION OF HUMAN CELL STRAINS.

  1963cited by this paper
• Surmise and Fact on the Nature of Cancer

  1959cited by this paper
• ROLE OF CHROMOSOMES IN CANCEROGENESIS, AS STUDIED IN SERIAL TISSUE CULTURE OF MAMMALIAN CELLS

  1958cited by this paper
• On Cancer

  1817cited by this paper
• Zur Frage der Entstehung maligner Tumoren

  year unknowncited by this paper

• Evidence of cancer-linked rodent zoonoses from biophysical genomic variations

  2023cites this paper
• Investigating the Genotoxic Effect of Gamma Irradiation on L929 Cells after Vinblastine Treatment Using Micronucleus Assay on Cytokinesis-blocked Binucleated Cells

  2019cites this paper
• Meta-Analysis of Cancer Triploidy: Whole-Genome Rearrangements in Male Human Tumours Are Characterised by XXY Karyotypes

  2019cites this paper
• Is cancer progression caused by gradual or simultaneous acquisitions of new chromosomes?

  2018cites this paper
• Speciation Theory of Carcinogenesis Explains Karyotypic Individuality and Long Latencies of Cancers

  2018cites this paper
• Abstracts from the 3rd Conference on Aneuploidy and Cancer: Clinical and Experimental Aspects

  2017cites this paper
• Somatic Genetic Variation in Children: from Mosaicism to Cancer

  2017cites this paper
• Atavism Theory—An Introductory Discourse

  2017cites this paper
• Establishment and characterization of a new feline mammary cancer cell line, FkMTp

  2016cites this paper
• Inherent variability of cancer-specific aneuploidy generates metastases

  2016cites this paper
• Why Chemotherapy Does Not Work: Cancer Genome Evolution and the Illusion of Oncogene Addiction

  2016cites this paper
• Effective Drug Treatment Induces Drug Resistance Through Rapid Genome Alteration-Mediated Cancer Evolution

  2016cites this paper
• Fuzzy inheritance: A novel form of somatic cell inheritance that regulates cell population heterogeneity

  2016cites this paper
• Step-wise and punctuated genome evolution drive phenotype changes of tumor cells.

  2015cites this paper
• Karyotype alteration generates the neoplastic phenotypes of SV40-infected human and rodent cells

  2015cites this paper
• Cell-Cell Fusion, Chemotaxis and Metastasis

  2015cites this paper
• BubbleTree: an intuitive visualization to elucidate tumoral aneuploidy and clonality using next generation sequencing data

  2015cites this paper
• Chromosome mis-segregation and cytokinesis failure in trisomic human cells

  2015cites this paper
• Evolutionary mechanism unifies the hallmarks of cancer

  2015cites this paper
• HEK293 in cell biology and cancer research: phenotype, karyotype, tumorigenicity, and stress-induced genome-phenotype evolution.

  2015cites this paper
• Imbalance is not an impediment: understanding the natural imbalances of Sex and B-chromosomes in species by understanding cancer karyotypes

  2015cites this paper
• Karyotypic evolutions of cancer species in rats during the long latent periods after injection of nitrosourea

  2014cites this paper
• Size Does Matter: Why Polyploid Tumor Cells are Critical Drug Targets in the War on Cancer

  2014cites this paper
• The Sex Chromosomes of Frogs: Variability and Tolerance Offer Clues to Genome Evolution and Function

  2014cites this paper
• The FHIT gene product: tumor suppressor and genome “caretaker”

  2014cites this paper
• Xenopatients 2.0: Reprogramming the epigenetic landscapes of patient-derived cancer genomes

  2014cites this paper
• Organotypic Slice Culture of Salamander Limbs: Identification and Investigation of Nerve Derived BMP2 in an Organotypic In Vitro Assay

  2014cites this paper
• Preliminary Results on Using Array Comparative Genomic Hybridization of Colorectal Cancer Tissues

  2014cites this paper
• Reprogramming the epigenetic landscapes of patient-derived cancer genomes

  2014cites this paper
• Life-Cycling of Cancer: New Concept

  2013cites this paper
• Human Interphase Chromosomes

  2013cites this paper
• Evolution Theory: Its Practical Relevance for Understanding Tumor Development and Specifying Tumor Therapy

  2013cites this paper
• Immortality of cancers

  2013cites this paper
• Will we cure cancer by sequencing thousands of genomes?

  2013cites this paper
• Chromosomal heterogeneity and instability characterize pediatric medulloblastoma cell lines and affect neoplastic phenotype

  2013cites this paper
• Cancer Karyotypes: Survival of the Fittest

  2013cites this paper
• Technological Solutions in Human Interphase Cytogenetics

  2013cites this paper
• Nature of nontargeted radiation effects observed during fractionated irradiation-induced thymic lymphomagenesis in mice

  2013cites this paper
• Cancer Genes and Chromosome Instability

  2013cites this paper
• Individual karyotypes at the origins of cervical carcinomas

  2013cites this paper
• The Hypothesis on Function of Glycosphingolipids and ABO Blood Groups Revisited

  2012cites this paper
• Cellular exposure to muscle relaxants and propofol could lead to genomic instability in vitro

  2012cites this paper
• Tumour heterogeneity and drug resistance: personalising cancer medicine through functional genomics.

  2012cites this paper
• Evolutionary karyotypic theory of cancer versus conventional cancer gene mutation theory

  2012influential citation
• An investigation of chromosomal instability survival mechanisms in cancer

  2012cites this paper
• Immortalization and malignant transformation of Eukaryotic cells

  2012cites this paper
• Origin of metastases: Subspecies of cancers generated by intrinsic karyotypic variations

  2012cites this paper
• Chromosomal instability induced by mammography X-rays in primary human fibroblasts from BRCA1 and BRCA2 mutation carriers

  2012cites this paper
• Vasculogenic Mimicry As A Tumor Tissue-Produced Biofilm and an “ Apogenetic ” ECM Controlling Element

  2011cites this paper
• Cancer: beyond speciation.

  2011cites this paper
• Cytogenetic polyclonality of breast carcinomas : Association with Clinico‐Pathological Characteristics and Outcome

  2011influential citation
• Is carcinogenesis a form of speciation?

  2011cites this paper
• The origins of cancer robustness and evolvability.

  2011cites this paper
• Decoding the genome beyond sequencing: the new phase of genomic research.

  2011cites this paper
• Mechanisms of aneuploidy and its suppression by tumour suppressor proteins.

  2011cites this paper
• SEX REDUCES GENETIC VARIATION: A MULTIDISCIPLINARY REVIEW

  2011cites this paper
• How mitotic errors contribute to karyotypic diversity in cancer.

  2011influential citation
• Chromosomal instability confers intrinsic multidrug resistance.

  2011cites this paper
• Dr Jekyll and Mr Hyde: role of aneuploidy in cellular adaptation and cancer.

  2010cites this paper
• Transgenic oncogenes induce oncogene-independent cancers with individual karyotypes and phenotypes.

  2010influential citation
• Characterization of two human lung adenocarcinoma cell lines by reciprocal chromosome painting.

  2010cites this paper
• Mitotic chromosomal instability and cancer: mouse modelling of the human disease

  2010cites this paper
• Human interphase chromosomes: a review of available molecular cytogenetic technologies

  2010cites this paper
• Targeting karyotypic complexity and chromosomal instability of cancer cells.

  2010cites this paper
• Tracking profiles of genomic instability in spontaneous transformation and tumorigenesis

  2010cites this paper