We aimed to assess the effect of invasive group A streptococcal (GAS) infection and the potential effects of a multivalent GAS vaccine in New Zealand. During January 2005–December 2006, we conducted prospective population-based laboratory surveillance of Auckland residents admitted to all public hospitals with isolation of GAS from normally sterile sites. Using emm typing, we identified 225 persons with confirmed invasive GAS infection (median 53 years of age; range 0–97 years). Overall incidence was 8.1 cases per 100,00 persons per year (20.4/100,000/year for Maori and Pacific Islanders; 24.4/100,000/year for persons >65 years of age; 33/100,000/year for infants <1 year of age). Nearly half (49%) of all cases occurred in Auckland’s lowest socioeconomic quintile. Twenty-two persons died, for an overall case-fatality rate of 10% (63% for toxic shock syndrome). Seventy-four percent of patients who died had an underlying condition. To the population in our study, the proposed 26-valent vaccine would provide limited benefit.
Invasive Group A Streptococcal Infection and Vaccine Implications, Auckland, New Zealand
A. Safar,D. Lennon,J. Stewart,A. Trenholme,D. Drinković,B. Peat,Susan L. Taylor,K. Read,S. Roberts,L. Voss
Published 2011 in Emerging Infectious Diseases
ABSTRACT
PUBLICATION RECORD
- Publication year
2011
- Venue
Emerging Infectious Diseases
- Publication date
2011-06-01
- Fields of study
Medicine, Environmental Science
- Identifiers
- External record
- Source metadata
Semantic Scholar, PubMed
CITATION MAP
EXTRACTION MAP
CLAIMS
CONCEPTS
- 26-valent vaccine
A proposed multivalent group A streptococcal vaccine containing 26 emm-type antigens.
Aliases: proposed 26-valent vaccine
- adults over 65 years of age
Older adults above 65 years old, used here as an age-stratified group.
Aliases: persons >65 years of age
- auckland public hospitals
The set of public hospitals in Auckland that served as the case-finding setting for the surveillance.
Aliases: all public hospitals in Auckland
- case-fatality rate
The proportion of confirmed cases that died from the infection during the observed period.
Aliases: fatality rate
- infants under 1 year of age
Children younger than one year old, used here as an age-stratified group.
Aliases: infants <1 year of age
- invasive group a streptococcal infection
An infection caused by group A Streptococcus isolated from a normally sterile site.
Aliases: invasive GAS infection, GAS infection
- maori and pacific islanders
Population groups in New Zealand used here for comparing disease incidence across ethnic groups.
Aliases: Māori and Pacific Islanders
- prospective population-based laboratory surveillance
A forward-looking surveillance design that collects laboratory-confirmed cases from a defined population.
Aliases: population-based laboratory surveillance
- socioeconomic quintile
A rank-based grouping that divides the population into five levels of socioeconomic deprivation or advantage.
Aliases: lowest socioeconomic quintile
- toxic shock syndrome
A severe toxin-mediated clinical syndrome associated here with invasive group A streptococcal infection.
Aliases: TSS
- underlying condition
A pre-existing medical condition present in a patient who died from invasive infection.
Aliases: underlying medical condition
REFERENCES
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CITED BY
Showing 1-42 of 42 citing papers · Page 1 of 1