The DNA Polymerase Gamma R953C Mutant Is Associated with Antiretroviral Therapy-Induced Mitochondrial Toxicity

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Antimicrobial Agents and Chemotherapy

• Publication date

  2016-07-05

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1128/AAC.00976-16PMID 27381400PMCID PMC4997837
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Antiretroviral therapy–induced toxicity is associated with increased mRNA expression of telomerase

  2015cited by this paper
• Antiretroviral Therapy-Induced Mitochondrial Toxicity: Potential Mechanisms Beyond Polymerase-γ Inhibition

  2014cited by this paper
• Mutations in human DNA polymerase γ confer unique mechanisms of catalytic deficiency that mirror the disease severity in mitochondrial disorder patients.

  2013cited by this paper
• Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE)-like phenotype: an expanded clinical spectrum of POLG1 mutations

  2012cited by this paper
• POLG1 Arg953Cys mutation: Expanded phenotype and recessive inheritance in a Brazilian family

  2012cited by this paper
• Mitochondrial DNA polymerase γ mutations: an ever expanding molecular and clinical spectrum

  2011cited by this paper
• R964C Mutation of DNA Polymerase γ Imparts Increased Stavudine Toxicity by Decreasing Nucleoside Analog Discrimination and Impairing Polymerase Activity

  2009cited by this paper
• Relationship between polymerase gamma (POLG) polymorphisms and antiretroviral therapy-induced lipodystrophy in HIV-1 infected patients: a case-control study.

  2009cited by this paper
• Increased mtDNA Levels Without Change in Mitochondrial Enzymes in Peripheral Blood Mononuclear Cells of Infants Born to HIV-Infected Mothers on Antiretroviral Therapy

  2008cited by this paper
• Novel mutation of human DNA polymerase gamma associated with mitochondrial toxicity induced by anti-HIV treatment.

  2007cited by this paper
• Phenotypic spectrum associated with mutations of the mitochondrial polymerase γ gene. Commentary

  2006cited by this paper
• Phenotypic spectrum associated with mutations of the mitochondrial polymerase gamma gene.

  2006cited by this paper
• Infantile hepatocerebral syndromes associated with mutations in the mitochondrial DNA polymerase-gammaA.

  2005cited by this paper
• Consequences of mutations in human DNA polymerase gamma.

  2005cited by this paper
• A modified procedure for quantitative analysis of mtDNA, detecting mtDNA depletion.

  2005cited by this paper
• Consequences of mutations in human DNA polymerase γ

  2005cited by this paper
• DNA polymerase gamma, the mitochondrial replicase.

  2004cited by this paper
• DNA Polymerase γ, The Mitochondrial Replicase1

  2004cited by this paper
• Parkinsonism, premature menopause, and mitochondrial DNA polymerase gamma mutations: clinical and molecular genetic study.

  2004cited by this paper
• Structural determinants in human DNA polymerase gamma account for mitochondrial toxicity from nucleoside analogs.

  2003cited by this paper
• Hyperlactataemia and lactic acidosis during antiretroviral therapy: relevance, reproducibility and possible risk factors

  2002cited by this paper
• Pharmacology of nucleoside and nucleotide reverse transcriptase inhibitor-induced mitochondrial toxicity.

  2000cited by this paper
• Clinical manifestations and management of antiretroviral nucleoside analog-related mitochondrial toxicity.

  2000cited by this paper
• Adverse effects of reverse transcriptase inhibitors: mitochondrial toxicity as common pathway

  1998cited by this paper
• Mitochondrial toxicity of antiviral drugs

  1995cited by this paper

• Structural and Molecular Basis for Mitochondrial DNA Replication and Transcription in Health and Antiviral Drug Toxicity

  2023cites this paper
• Mitochondria as the Target of Hepatotoxicity and Drug-Induced Liver Injury: Molecular Mechanisms and Detection Methods

  2022cites this paper
• Heterozygous p.Y955C mutation in DNA polymerase γ leads to alterations in bioenergetics, complex I subunit expression, and mtDNA replication

  2022cites this paper
• A Critical Review of the Biochemical Mechanisms and Epigenetic Modifications in HIV- and Antiretroviral-Induced Metabolic Syndrome

  2021cites this paper
• The antiretroviral 2 0 ,3 0 -dideoxycytidine causes mitochondrial dysfunction in proliferating and differentiated HepaRG human cell cultures

  2021cites this paper
• The antiretroviral 2′,3′-dideoxycytidine causes mitochondrial dysfunction in proliferating and differentiated HepaRG human cell cultures

  2020cites this paper
• Identifying the role of PrimPol in TDF-induced toxicity and implications of its loss of function mutation in an HIV+ patient

  2020cites this paper
• The DNA Replication Machinery as Therapeutic Targets

  2019cites this paper
• DRAM Is Involved in Regulating Nucleoside Analog-Induced Neuronal Autophagy in a p53-Independent Manner

  2018cites this paper
• Off-Target Effects of Drugs that Disrupt Human Mitochondrial DNA Maintenance

  2017cites this paper