Aspergillus fumigatus Generates an Enhanced Th2-Biased Immune Response in Mice with Defective Cystic Fibrosis Transmembrane Conductance Regulator1

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Journal of Immunology

• Publication date

  2006-10-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4049/jimmunol.177.8.5186PMID 17015704
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Innate immune response in CF airway epithelia: hyperinflammatory?

  2006cited by this paper
• Calcium-dependent regulation of NF-(kappa)B activation in cystic fibrosis airway epithelial cells.

  2006cited by this paper
• Calcium-dependent regulation of NF-κB activation in cystic fibrosis airway epithelial cells

  2006cited by this paper
• Risk factors for allergic bronchopulmonary aspergillosis and sensitisation to Aspergillus fumigatus in patients with cystic fibrosis

  2006cited by this paper
• Prevalence of allergic bronchopulmonary aspergillosis in cystic fibrosis in an area with a high frequency of atopy.

  2005cited by this paper
• Effect of cystic fibrosis exacerbations on neutrophil function.

  2005cited by this paper
• 17beta-estradiol enhances heparin-binding epidermal growth factor-like growth factor production in human keratinocytes.

  2005cited by this paper
• Longitudinal development of mucoid Pseudomonas aeruginosa infection and lung disease progression in children with cystic fibrosis.

  2005cited by this paper
• Neutrophil elastase activates near-silent epithelial Na+ channels and increases airway epithelial Na+ transport.

  2005cited by this paper
• Sputum cathelicidin, urokinase plasminogen activation system components, and cytokines discriminate cystic fibrosis, COPD, and asthma inflammation.

  2005cited by this paper
• Reduced Three-Dimensional Motility in Dehydrated Airway Mucus Prevents Neutrophil Capture and Killing Bacteria on Airway Epithelial Surfaces1

  2005cited by this paper
• Enhanced Pseudomonas aeruginosa Biofilm Development Mediated by Human Neutrophils

  2005cited by this paper
• Reduced iC3b‐mediated phagocytotic capacity of pulmonary neutrophils in cystic fibrosis

  2005cited by this paper
• Lower Airway Inflammation in Infants with Cystic Fibrosis Detected by Newborn Screening

  2005cited by this paper
• Inhibition of NFAT Specifically in T Cells Prevents Allergic Pulmonary Inflammation1

  2004cited by this paper
• Increased airway epithelial Na+ absorption produces cystic fibrosis-like lung disease in mice

  2004cited by this paper
• Lymphocytes in cystic fibrosis lung disease: a tale of two immunities

  2004cited by this paper
• Local regulation of cystic fibrosis transmembrane regulator and epithelial sodium channel in airway epithelium.

  2004cited by this paper
• Neutrophil recruitment and airway epithelial cell involvement in chronic cystic fibrosis lung disease.

  2003cited by this paper
• Prevalence of Aspergillus fumigatus and other fungal species in the sputum of adult patients with cystic fibrosis

  2003cited by this paper
• The Phenotypic Consequences of CFTR Mutations

  2003cited by this paper
• A Prominent Role for Airway Epithelial NF-κB Activation in Lipopolysaccharide-Induced Airway Inflammation1

  2003cited by this paper
• Induction of NFATc2 Expression by Interleukin 6 Promotes T Helper Type 2 Differentiation

  2002cited by this paper
• Serologic IgE immune responses against Aspergillus fumigatus and Candida albicans in patients with cystic fibrosis.

  2002cited by this paper
• Regulation of Murine Airway Surface Liquid Volume by CFTR and Ca2+-activated Cl− Conductances

  2002cited by this paper
• Immunopathogenesis of allergic bronchopulmonary aspergillosis in cystic fibrosis.

  2002cited by this paper
• Interleukin-13 mediates a fundamental pathway for airway epithelial mucus induced by CD4 T cells and interleukin-9.

  2002cited by this paper
• Allergic bronchopulmonary aspergillosis

  2002cited by this paper
• Allergic bronchopulmonary aspergillosis in a lung transplant patient successfully treated with nebulized amphotericin.

  2002cited by this paper
• Cystic fibrosis transmembrane conductance regulator gene mutations: do they play a role in the aetiology of allergic bronchopulmonary aspergillosis?

  2002cited by this paper
• Distinct pattern of immune cell population in the lung of human fetuses with cystic fibrosis.

  2001cited by this paper
• Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets.

  2001cited by this paper
• NFATc1 and NFATc2 together control both T and B cell activation and differentiation.

  2001cited by this paper
• Quantitative analysis of inflammatory cells infiltrating the cystic fibrosis airway mucosa

  2001cited by this paper
• CFTR may play a role in regulated secretion by lymphocytes: a new hypothesis for the pathophysiology of cystic fibrosis

  2001cited by this paper
• Polarized Signaling via Purinoceptors in Normal and Cystic Fibrosis Airway Epithelia

  2001cited by this paper
• Selective export of MHC class I molecules from the ER after their dissociation from TAP.

  2000cited by this paper
• Allergic bronchopulmonary aspergillosis in cystic fibrosis. A European epidemiological study

  2000cited by this paper
• Allergic bronchopulmonary aspergillosis in cystic fibrosis. A European epidemiological study. Epidemiologic Registry of Cystic Fibrosis.

  2000cited by this paper
• Cytokine dysregulation in activated cystic fibrosis (CF) peripheral lymphocytes

  2000cited by this paper
• Th2-induced airway mucus production is dependent on IL-4Ralpha, but not on eosinophils.

  1999cited by this paper
• Altered respiratory epithelial cell cytokine production in cystic fibrosis.

  1999cited by this paper
• Patterns of medical practice in cystic fibrosis: Part I. Evaluation and monitoring of health status of patients

  1999cited by this paper
• Prophylactic antibiotic therapy is associated with an increased prevalence of Aspergillus colonization in adult cystic fibrosis patients.

  1999cited by this paper
• Interleukin-13: central mediator of allergic asthma.

  1998cited by this paper
• Interleukin-13: central mediator of allergic asthma

  1998cited by this paper
• [Allergic bronchopulmonary aspergillosis].

  1996influential reference
• Reduced IL‐10 secretion by CD4+ T lymphocytes expressing mutant cystic fibrosis transmembrane conductance regulator (CFTR)

  1996cited by this paper
• Transcript analysis of CFTR frameshift mutations in lymphocytes using the reverse transcription-polymerase chain reaction technique and the protein truncation test

  1996cited by this paper
• Clinical significance of the recovery of Aspergillus species from the respiratory secretions of cystic fibrosis patients

  1996cited by this paper
• Activation of CFTR chloride current by nitric oxide in human T lymphocytes.

  1995cited by this paper
• A common factor regulates both Th1‐ and Th2‐specific cytokine gene expression.

  1994cited by this paper
• Correction of lethal intestinal defect in a mouse model of cystic fibrosis by human CFTR.

  1994cited by this paper
• Production of a severe cystic fibrosis mutation in mice by gene targeting

  1993cited by this paper
• Role of dendritic cells in the priming of CD4+ T lymphocytes to peptide antigen in vivo.

  1993cited by this paper
• Mechanisms of eosinophil recruitment.

  1993cited by this paper
• Human lymphocytes transcribe the cystic fibrosis transmembrane conductance regulator gene and exhibit CF-defective cAMP-regulated chloride current.

  1992cited by this paper
• Human T cell activation through the activation-inducer molecule/CD69 enhances the activity of transcription factor AP-1.

  1992cited by this paper
• Long‐term fungal cultures from sputum of patients with cystic fibrosis

  1991cited by this paper
• Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells.

  1989cited by this paper
• Suppression of in vivo polyclonal IgE responses by monoclonal antibody to the lymphokine B-cell stimulatory factor 1.

  1986influential reference
• Identification of a cyclic-AMP-responsive element within the rat somatostatin gene.

  1986cited by this paper
• Characterization of the murine T cell surface molecule, designated L3T4, identified by monoclonal antibody GK1.5: similarity of L3T4 to the human Leu-3/T4 molecule.

  1983cited by this paper
• Evidence that the Thy‐1 molecule is the target for T cell mitogenic antibody against brain‐associated antigens

  1983cited by this paper
• Xenogeneic Monoclonal Antibodies to Mouse Lymphoid Differentiation Antigens *

  1979cited by this paper
• Aspergillosis and atopy in cystic fibrosis.

  1979cited by this paper

• The Cystic Fibrosis Transmembrane Conductance Receptor Brakes Allergic Airway Inflammation

  2025cites this paper
• CFTR negatively reprograms Th2 cell responses, and CFTR potentiation restrains allergic airway inflammation

  2025influential citation
• Aspergillus in Children and Young People with Cystic Fibrosis: A Narrative Review

  2025cites this paper
• Abnormal functional lymphoid tolerance and enhanced myeloid exocytosis are characteristics of resting and stimulated PBMCs in cystic fibrosis patients

  2024cites this paper
• Type 2 inflammation in cystic fibrosis is a predictor of mortality and targeted with CFTR modulator therapy

  2024cites this paper
• Association between Cystic Fibrosis exacerbations, lung function, T2 inflammation and microbiological colonization

  2023cites this paper
• The Impact of CFTR Modulator Triple Therapy on Type 2 Inflammatory Response in Patients with Cystic Fibrosis

  2023cites this paper
• The impact of CFTR modulator triple therapy on type 2 inflammatory response in patients with cystic fibrosis

  2023cites this paper
• Serum Cytokine Biomarkers for Use in Diagnosing Pulmonary Tuberculosis versus Chronic Pulmonary Aspergillosis

  2023cites this paper
• Cystic Fibrosis Reprograms Airway Epithelial IL-33 Release and Licenses IL-33 Dependent Inflammation.

  2023cites this paper
• Microbial Components and Effector Molecules in T Helper Cell Differentiation and Function

  2023cites this paper
• Frequencies of pathogenic CFTR variants in Greek cystic fibrosis patients with allergic bronchopulmonary aspergillosis and Aspergillus fumigatus chronic colonization: A retrospective cohort study.

  2022cites this paper
• Novel Treatment Approach for Aspergilloses by Targeting Germination

  2022influential citation
• Occurrence of Cystic Fibrosis Transmembrane Conductance Regulator Gene Mutations in Patients with Allergic Bronchopulmonary Aspergillosis Complicating Asthma

  2022influential citation
• Aspergillus fumigatus Strain-Specific Conidia Lung Persistence Causes an Allergic Broncho-Pulmonary Aspergillosis-Like Disease Phenotype

  2021cites this paper
• Review of current and future therapeutics in ABPA

  2021cites this paper
• Had it happened without Christmas? Thoracic emphysema and Allergic Bronchopulmonary Aspergillosis in a juvenile CF-patient with G551D receiving ivacaftor

  2021cites this paper
• Fungal Infection and Inflammation in Cystic Fibrosis

  2021cites this paper
• Novel Anti-Cytokine Strategies for Prevention and Treatment of Respiratory Allergic Diseases

  2021cites this paper
• Would it have happened without Christmas? Thoracic emphysema and allergic bronchopulmonary aspergillosis in a juvenile cystic fibrosis patient with the G551D mutation receiving ivacaftor

  2021cites this paper
• CF Fungal Disease in the Age of CFTR Modulators

  2021influential citation
• Use of mepolizumab in adult patients with cystic fibrosis and an eosinophilic phenotype: case series

  2020cites this paper
• Strain specific persistence in the murine lung of Aspergillus fumigatus conidia causes an Allergic Broncho-Pulmonary Aspergillosis-like disease phenotype

  2020cites this paper
• CFTR is a negative regulator of γδ T cell IFN-γ production and antitumor immunity

  2020cites this paper
• Coinfection with Pseudomonas aeruginosa and Aspergillus fumigatus in cystic fibrosis

  2020cites this paper
• CFTR is a negative regulator of γδ T cell IFN-γ production and antitumor immunity

  2020cites this paper
• Protective Effect of S-Allyl Cysteine Against Neonatal Asthmatic Rats

  2020cites this paper
• Fungal Infections and ABPA

  2020cites this paper
• BPIFA1 regulates lung neutrophil recruitment and interferon signaling during acute inflammation.

  2019cites this paper
• Clinical relevance of Aspergillus fumigatus sensitization in cystic fibrosis

  2019cites this paper
• The long pentraxin PTX3 as a functional ancestor of antibodies in the immune response to Aspergillus fumigatus

  2019cites this paper
• Fungal allergen beta-glucans trigger p 38 mitogen-activated protein kinase-mediated IL-6 translation in lung epithelial cells

  2018cites this paper
• A mast cell-ILC2-Th9 pathway promotes lung inflammation in cystic fibrosis

  2017cites this paper
• Peripheral immune cell abnormalities associated with cystic fibrosis

  2017cites this paper
• Host Response to Pulmonary Fungal Infections: a Highlight on Cell-Driven Immunity to Cryptococcus Species and Aspergillus fumigatus

  2017cites this paper
• Aspergillus in chronic lung disease: Modeling what goes on in the airways

  2017cites this paper
• Consequences of cystic fibrosis transmembrane regulator mutations on inflammatory cells

  2016cites this paper
• CD11b+ and Sca-1+ Cells Exert the Main Beneficial Effects of Systemically Administered Bone Marrow-Derived Mononuclear Cells in a Murine Model of Mixed Th2/Th17 Allergic Airway Inflammation

  2016cites this paper
• CD11b+ and Sca-1+ Cells Exert the Main Beneficial Effects of Systemically Administered Bone Marrow-DerivedMononuclearCellsinaMurineModel

  2016cites this paper
• Enabling Technologies for Cell-Based Clinical Translation Freshly Thawed and Continuously Cultured Human Bone Marrow-Derived Mesenchymal Stromal Cells Comparably Ameliorate Allergic Airways Inflammation in Immunocompetent Mice

  2015cites this paper
• High Peripheral Blood Th17 Percent Associated with Poor Lung Function in Cystic Fibrosis

  2015cites this paper
• Necrotising pneumonia and bronchiectasis in a previously healthy 30-year-old man

  2015cites this paper
• Fungi in Cystic Fibrosis and Non–Cystic Fibrosis Bronchiectasis

  2015cites this paper
• Systemic Administration of Human Bone Marrow‐Derived Mesenchymal Stromal Cell Extracellular Vesicles Ameliorates Aspergillus Hyphal Extract‐Induced Allergic Airway Inflammation in Immunocompetent Mice

  2015cites this paper
• Suppression of epithelial signal transducer and activator of transcription 1 activation by extracts of Aspergillus fumigatus.

  2014cites this paper
• Mesenchymal Stromal Cells Mediate Aspergillus Hyphal Extract‐Induced Allergic Airway Inflammation by Inhibition of the Th17 Signaling Pathway

  2014cites this paper
• Flagellin Induces Myeloid-Derived Suppressor Cells: Implications for Pseudomonas aeruginosa Infection in Cystic Fibrosis Lung Disease

  2013cites this paper
• Th17/Treg imbalance in murine cystic fibrosis is linked to indoleamine 2,3-dioxygenase deficiency but corrected by kynurenines.

  2013cites this paper
• High Mobility Group Box-1 mediates hyperoxia-induced impairment of Pseudomonas aeruginosa clearance and inflammatory lung injury in mice.

  2013cites this paper
• Fibrosis Lung Disease Infection in Cystic Pseudomonas aeruginosa Suppressor Cells: Implications for Flagellin Induces Myeloid-Derived

  2013cites this paper
• Airway inflammation in cystic fibrosis: molecular mechanisms and clinical implications

  2013cites this paper
• Acute inflammation induced by the biopsy of mouse mammary tumors promotes the development of metastasis

  2013cites this paper
• Conductance Regulator-Deficient Mice Cystic Fibrosis Transmembrane Locus of Elevated Lymphocyte Numbers in Hyperresponsiveness and a Chromosome 7 Strain-Dependent Airway

  2012influential citation
• Cystic fibrosis transmembrane conductance regulator regulates epithelial cell response to Aspergillus and resultant pulmonary inflammation.

  2012cites this paper
• Strain-Dependent Airway Hyperresponsiveness and a Chromosome 7 Locus of Elevated Lymphocyte Numbers in Cystic Fibrosis Transmembrane Conductance Regulator-Deficient Mice

  2012influential citation
• The effect of Aspergillus fumigatus infection on vitamin D receptor expression in cystic fibrosis.

  2012cites this paper
• Inhibition of High-Mobility Group Box 1 Protein (HMGB1) Enhances Bacterial Clearance and Protects against Pseudomonas Aeruginosa Pneumonia in Cystic Fibrosis

  2012cites this paper
• Inflammation in aspergillosis: the good, the bad, and the therapeutic

  2012cites this paper
• Link between CFTR mutations and ABPA: a systematic review and meta‐analysis

  2012cites this paper
• Effects of Aspergillus fumigatus colonization on lung function in cystic fibrosis

  2012cites this paper
• Role of IL-6 in Asthma and Other Inflammatory Pulmonary Diseases

  2012cites this paper
• CFTR regulates epithelial cell response to Aspergillus and resultant pulmonary inflammation

  2011cites this paper
• Impact of Aspergillus fumigatus in allergic airway diseases

  2011influential citation
• Mechanisms underlying pulmonary neutrophilia versus eosinophilia in fungal allergy

  2011cites this paper
• Fungal allergen β-glucans trigger p38 mitogen-activated protein kinase-mediated IL-6 translation in lung epithelial cells.

  2011cites this paper
• Bone Marrow‐Derived Mesenchymal Stromal Cells Inhibit Th2‐Mediated Allergic Airways Inflammation in Mice

  2011cites this paper
• Approches transcriptomiques dans l’étude de la fibrose kystique

  2010cites this paper
• Local innate host response and filamentous fungi in patients with cystic fibrosis.

  2010cites this paper
• ENaC‐mediated effects assessed by MRI in a rat model of hypertonic saline‐induced lung hydration

  2010cites this paper
• The prevalence of simultaneous colonization by bacteria and fungi in the CF lung

  2010cites this paper
• Mixed bacterial-fungal infections in the CF respiratory tract.

  2010cites this paper
• Cystic fibrosis, atopy, asthma and ABPA.

  2010cites this paper
• NO2 inhalation induces maturation of pulmonary CD11c+ cells that promote antigenspecific CD4+ T cell polarization

  2010cites this paper
• Th2 allergic immune response to inhaled fungal antigens is modulated by TLR‐4‐independent bacterial products

  2009cites this paper
• Pathway prediction by bioinformatic analysis of the untranslated regions of the CFTR mRNA.

  2009cites this paper
• AllergensProduction Induced by Inhaled Fungal IL-6 Is Required for Airway Mucus

  2009cites this paper
• Évaluation et prise en charge du risque fongique chez le patient atteint de mucoviscidose : résultats de la phase d'inclusion de l'étude Mucofong au CHU de Grenoble

  2009cites this paper
• How useful are cystic fibrosis mouse models

  2009cites this paper
• IL-6 Is Required for Airway Mucus Production Induced by Inhaled Fungal Allergens1

  2009cites this paper
• Immunological mechanisms behind the cystic fibrosis-ABPA link.

  2009cites this paper
• Chapter 46 – Allergic Bronchopulmonary Aspergillosis

  2008cites this paper
• DNA demethylation-dependent enhancement of toll-like receptor-2 gene expression in cystic fibrosis epithelial cells involves SP1-activated transcription

  2008cites this paper
• GbdR Regulates Pseudomonas aeruginosa plcH and pchP Transcription in Response to Choline Catabolites

  2008cites this paper
• GbdR Regulates Pseudomonas aeruginosa plcH and pchP Transcription in Response to Choline Catabolites †

  2008cites this paper
• Functional group/guild modelling of inter-specific pathogen interactions: A potential tool for predicting the consequences of co-infection

  2008cites this paper
• Novel therapies for the treatment of cystic fibrosis: new developments in gene and stem cell therapy.

  2007cites this paper
• Nitrogen Dioxide Promotes Allergic Sensitization to Inhaled Antigen1

  2007cites this paper