Activity levels of cathepsins B and L in tumor cells are a biomarker for efficacy of reovirus-mediated tumor cell killing

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Cancer Gene Therapy

• Publication date

  2015-01-30

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/cgt.2015.4PMID 25633482
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The Nogo receptor NgR1 mediates infection by mammalian reovirus.

  2014cited by this paper
• Phase 1 clinical trial of intratumoral reovirus infusion for the treatment of recurrent malignant gliomas in adults.

  2014cited by this paper
• Reolysin is a novel reovirus-based agent that induces endoplasmic reticular stress-mediated apoptosis in pancreatic cancer

  2013cited by this paper
• Oncolytic Reovirus in Canine Mast Cell Tumor

  2013cited by this paper
• Recent clinical experience with oncolytic viruses.

  2012cited by this paper
• Reovirus: A Targeted Therapeutic—Progress And Potential

  2012cited by this paper
• Reovirus exerts potent oncolytic effects in head and neck cancer cell lines that are independent of signalling in the EGFR pathway

  2012cited by this paper
• Phase I/II Trial of Carboplatin and Paclitaxel Chemotherapy in Combination with Intravenous Oncolytic Reovirus in Patients with Advanced Malignancies

  2012cited by this paper
• TGF-β signaling, activated stromal fibroblasts, and cysteine cathepsins B and L drive the invasive growth of human melanoma cells.

  2012cited by this paper
• Reovirus therapy stimulates endoplasmic reticular stress, NOXA induction, and augments bortezomib-mediated apoptosis in multiple myeloma

  2012cited by this paper
• Phase II Trial of Intravenous Administration of Reolysin® (Reovirus Serotype-3-dearing Strain) in Patients with Metastatic Melanoma.

  2012cited by this paper
• Phase II trial of intravenous administration of Reolysin(®) (Reovirus Serotype-3-dearing Strain) in patients with metastatic melanoma.

  2012cited by this paper
• TRAIL and Noxa Are Selectively Upregulated in Prostate Cancer Cells Downstream of the RIG-I/MAVS Signaling Pathway by Nonreplicating Sendai Virus Particles

  2012cited by this paper
• Apoptosis Induced by Mammalian Reovirus Is Beta Interferon (IFN) Independent and Enhanced by IFN Regulatory Factor 3- and NF-κB-Dependent Expression of Noxa

  2011cited by this paper
• Involvement of Noxa in mediating cellular ER stress responses to lytic virus infection.

  2011cited by this paper
• Procathepsin L secretion, which triggers tumour progression, is regulated by Rab4a in human melanoma cells.

  2011cited by this paper
• Susceptibility of mantle cell lymphomas to reovirus oncolysis.

  2010cited by this paper
• Reovirus infection of cancer cells is not due to activated Ras pathway

  2009cited by this paper
• Profiling of transcripts and proteins modulated by K-ras oncogene in the lung tissues of K-ras transgenic mice by omics approaches.

  2009cited by this paper
• Proapoptotic signaling induced by RIG-I and MDA-5 results in type I interferon-independent apoptosis in human melanoma cells.

  2009cited by this paper
• Transient infection of freshly isolated human colorectal tumor cells by reovirus T3D intermediate subviral particles

  2008cited by this paper
• Protein Kinase PKR Plays a Stimulus- and Virus-Dependent Role in Apoptotic Death and Virus Multiplication in Human Cells

  2007cited by this paper
• Proteolytic Disassembly Is a Critical Determinant for Reovirus Oncolysis

  2007cited by this paper
• Distinct RIG-I and MDA5 Signaling by RNA Viruses in Innate Immunity

  2007cited by this paper
• Acquired resistance to reoviral oncolysis in Ras-transformed fibrosarcoma cells

  2007cited by this paper
• Increased Expression and Activity of Nuclear Cathepsin L in Cancer Cells Suggests a Novel Mechanism of Cell Transformation

  2007cited by this paper
• Tumor cell-derived and macrophage-derived cathepsin B promotes progression and lung metastasis of mammary cancer.

  2006cited by this paper
• β1 Integrin Mediates Internalization of Mammalian Reovirus

  2006cited by this paper
• Beta1 integrin mediates internalization of mammalian reovirus.

  2006cited by this paper
• Junctional Adhesion Molecule A Serves as a Receptor for Prototype and Field-Isolate Strains of Mammalian Reovirus

  2005cited by this paper
• Neutrophil elastase, an acid-independent serine protease, facilitates reovirus uncoating and infection in U937 promonocyte cells

  2005cited by this paper
• The preferential cytotoxicity of reovirus for certain transformed cell lines

  2005cited by this paper
• Enhanced cathepsin L expression is mediated by different Ras effector pathways in fibroblasts and epithelial cells

  2004cited by this paper
• Cathepsin S Supports Acid-independent Infection by Some Reoviruses*

  2004cited by this paper
• Reovirus oncolysis: the Ras/RalGEF/p38 pathway dictates host cell permissiveness to reovirus infection.

  2004cited by this paper
• Cathepsin L and Cathepsin B Mediate Reovirus Disassembly in Murine Fibroblast Cells*

  2002cited by this paper
• Interaction of Human Breast Fibroblasts with Collagen I Increases Secretion of Procathepsin B*

  2002cited by this paper
• Addition of Exogenous Protease Facilitates Reovirus Infection in Many Restrictive Cells

  2002cited by this paper
• Mutant Cells Selected during Persistent Reovirus Infection Do Not Express Mature Cathepsin L and Do Not Support Reovirus Disassembly

  1999cited by this paper
• Modulation of invasive properties of murine squamous carcinoma cells by heterologous expression of cathepsin B and cystatin C

  1999cited by this paper
• Reovirus therapy of tumors with activated Ras pathway.

  1998cited by this paper
• The v-erbB oncogene confers enhanced cellular susceptibility to reovirus infection

  1996cited by this paper
• Transcription In Vitro by Reovirus-Associated Ribonucleic Acid-Dependent Polymerase

  1970cited by this paper
• The effect of infection with fowl plague virus on protein synthesis in chick embryo cells.

  1970cited by this paper

• Tumor-specific biochemical nanoconversion of self-assembled peptide-conjugated paclitaxel-docetaxel-based nanoparticles

  2025cites this paper
• Oncolytic Reovirus-Induced Prostaglandin E2 Production in Human Tumor Cells.

  2025cites this paper
• Reovirus oncolysis and the next frontiers for this unique oncoviral immunotherapy.

  2025cites this paper
• Human Melanoma and Glioblastoma Cells Express Cathepsins Supporting Reovirus Moscow Strain Infection

  2024cites this paper
• Cinnamaldehyde as a Potential Cathepsin‐B Inhibitor: A Comparative Investigation with some Commercial Anticancer Drugs

  2024cites this paper
• Enhancing Targeted Drug Delivery through Cell‐Specific Endosomal Escape

  2024cites this paper
• Involvement of Protein Kinase R in Double-Stranded RNA-Induced Proteasomal Degradation of Hypoxia Inducible Factor-1α

  2023cites this paper
• Modulation of Reoviral Cytolysis (II): Cellular Stemness

  2023cites this paper
• Oncolytic virotherapy in cancer treatment: challenges and optimization prospects

  2023cites this paper
• Reovirus genomic diversity confers plasticity for protease utility during adaptation to intracellular uncoating

  2023cites this paper
• Mesenchymal stem cell carriers enhance antitumor efficacy induced by oncolytic reovirus in acute myeloid leukemia.

  2021cites this paper
• A Double Photocage Strategy to Construct Light-Controllable and Spatiotemporally Trackable Cathepsin B Activity-Based Probes.

  2021cites this paper
• Oncolytic reovirus-mediated killing of mouse cancer-associated fibroblasts.

  2021cites this paper
• Synthesis and Characterization of Dual-Sensitive PAMAM Derivatives Conjugated with Enzyme Cleavable Peptides as Gene Carriers

  2021cites this paper
• Evolving Role of Oncolytic Virotherapy: Challenges and Prospects in Clinical Practice.

  2021cites this paper
• A TGFβ Signaling Inhibitor, SB431542, Inhibits Reovirus-mediated Lysis of Human Hepatocellular Carcinoma Cells in a TGFβ-independent Manner

  2021cites this paper
• Cathepsin B-Responsive Liposomes for Controlled Anticancer Drug Delivery in Hep G2 Cells

  2020cites this paper
• Early detection of non-small cell lung cancer in liquid biopsies by ultrasensitive protease activity analysis

  2020cites this paper
• Cathepsin B Turns Bioluminescence "On" for Tumor Imaging.

  2019cites this paper
• Optimizing oncolytic virotherapy in cancer treatment

  2019cites this paper
• Reovirus changes the expression of anti-apoptotic and proapoptotic proteins with the c-kit downregulation in canine mast cell tumor cell lines.

  2019cites this paper
• Breast Tumor-Associated Metalloproteases Restrict Reovirus Oncolysis by Cleaving the σ1 Cell Attachment Protein and Can Be Overcome by Mutation of σ1

  2019cites this paper
• Quantitative Proteome Responses to Oncolytic Reovirus in GM-CSF and M-CSF-Differentiated Bone Marrow-Derived Cells.

  2019cites this paper
• Systemically Administered Reovirus-Induced Downregulation of Hypoxia Inducible Factor-1α in Subcutaneous Tumors

  2018cites this paper
• Reducing Dendrimer Generation and PEG Chain Length Increases Drug Release and Promotes Anticancer Activity of PEGylated Polylysine Dendrimers Conjugated with Doxorubicin via a Cathepsin-Cleavable Peptide Linker.

  2018cites this paper
• Oncolytic Reovirus Inhibits Immunosuppressive Activity of Myeloid-Derived Suppressor Cells in a TLR3-Dependent Manner

  2018cites this paper
• Characterization of a replicating expanded tropism oncolytic reovirus carrying the adenovirus E4orf4 gene

  2018cites this paper
• Going (Reo)Viral: Factors Promoting Successful Reoviral Oncolytic Infection

  2018influential citation
• Integrin-targeted nano-sized polymeric systems for paclitaxel conjugation: a comparative study

  2017cites this paper
• Imaging Lysosomes and Secreted Cathepsins

  2017influential citation
• Cationic liposome-mediated delivery of reovirus enhances the tumor cell-killing efficiencies of reovirus in reovirus-resistant tumor cells.

  2017cites this paper
• Deciphering the mechanism(s) which limit reovirus spread in resistant lung and HNSCC cancer cells

  2016cites this paper
• Crystallographic, DFT and docking (cathepsin B) studies on an organotellurium(IV) compound

  2016cites this paper
• Optimising Reovirus Type 3 Dearing (Reolysin®) as an anti-cancer therapeutic

  2016influential citation
• Proteolytic Disassembly of Viral Outer Capsid Proteins Is Crucial for Reovirus-Mediated Type-I Interferon Induction in Both Reovirus-Susceptible and Reovirus-Refractory Tumor Cells

  2015cites this paper
• Evidence for Oncolytic Virotherapy: Where Have We Got to and Where Are We Going?

  2015cites this paper
• Comparative proteomic analyses demonstrate enhanced interferon and STAT-1 activation in reovirus T3D-infected HeLa cells

  2015cites this paper
• Potential for Improving Potency and Specificity of Reovirus Oncolysis with Next-Generation Reovirus Variants

  2015cites this paper
• Reovirus double-stranded RNA genomes and polyI:C induce down-regulation of hypoxia-inducible factor 1α.

  2015cites this paper