Ventricular natriuretic peptide

Abstract Ventricular natriuretic peptide (VNP) is a cardiac hormone found in chondrostei and primitive teleostei, such as sturgeon, bichir, eel, and trout. The VNP gene does not exist in mammals, reptiles, amphibians, and advanced teleost species (medaka and pufferfish). VNP has a long C-terminal tail sequence extending from an intramolecular ring, which is distinct in molecular structure from other NPs. VNP shares both A-type and B-type natriuretic peptide receptors (NPR-A and NPR-B) with ANP/BNP and CNP, respectively. A major stimulus of VNP release is acute salt-load in eels but chronic volume-load in trout. Like ANP, VNP potently decreases plasma Na+ concentration by inhibiting drinking and subsequent intestinal NaCl absorption in seawater-adapted eels. VNP also has a strong hypotensive effect in eel and trout. In summary, VNP is important for osmoregulation and blood pressure control in teleost fish.

• Publication year

  2021

• Venue

  Handbook of Hormones

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/B978-0-12-801028-0.00186-0
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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