Microtubule-damaging Chemotherapeutic Agent-mediated Mitotic Arrest and Apoptosis Induction in Tumor Cells

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Journal of Life Science

• Publication date

  2016-03-30

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.5352/JLS.2016.26.3.376
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Dependency of 2-methoxyestradiol-induced mitochondrial apoptosis on mitotic spindle network impairment and prometaphase arrest in human Jurkat T cells.

  2015cited by this paper
• Docetaxel-induced polyploidization may underlie chemoresistance and disease relapse.

  2015influential reference
• Tetraploidy and tumor development

  2014cited by this paper
• Prometaphase arrest-dependent phosphorylation of Bcl-2 family proteins and activation of mitochondrial apoptotic pathway are associated with 17α-estradiol-induced apoptosis in human Jurkat T cells.

  2013cited by this paper
• Prometaphase arrest-dependent phosphorylation of Bcl-2 and Bim reduces the association of Bcl-2 with Bak or Bim, provoking Bak activation and mitochondrial apoptosis in nocodazole-treated Jurkat T cells

  2013cited by this paper
• Chemotherapeutic targeting of cell death pathways.

  2012cited by this paper
• The hallmarks of cancer

  2012cited by this paper
• Cdk1/cyclin B plays a key role in mitotic arrest-induced apoptosis by phosphorylation of Mcl-1, promoting its degradation and freeing Bak from sequestration.

  2012cited by this paper
• Defective Cell Cycle Checkpoints as Targets for Anti-Cancer Therapies

  2011cited by this paper
• Cell Cycle Checkpoints

  2011cited by this paper
• From signaling pathways to microtubule dynamics: the key players.

  2010cited by this paper
• Control of mitotic spindle length.

  2010cited by this paper
• The BCL-2 family reunion.

  2010cited by this paper
• Phosphorylation of Mcl‐1 by CDK1–cyclin B1 initiates its Cdc20‐dependent destruction during mitotic arrest

  2010cited by this paper
• Cyclin-Dependent Kinase 1-Mediated Bcl-xL/Bcl-2 Phosphorylation Acts as a Functional Link Coupling Mitotic Arrest and Apoptosis

  2009cited by this paper
• The G2 DNA damage checkpoint: Could this ancient regulator be the Achilles heel of cancer?

  2009cited by this paper
• Bax activation by Bim?

  2009cited by this paper
• Regulation of microtubule dynamic instability.

  2009cited by this paper
• Cell cycle kinases as therapeutic targets for cancer

  2009cited by this paper
• Aurora B-mediated abscission checkpoint protects against tetraploidization.

  2009cited by this paper
• Linking kinetochore-microtubule binding to the spindle checkpoint.

  2008cited by this paper
• Taxanes, microtubules and chemoresistant breast cancer.

  2008cited by this paper
• Cyclin-dependent kinases and cell-cycle transitions: does one fit all?

  2008cited by this paper
• How do BCL-2 proteins induce mitochondrial outer membrane permeabilization?

  2008cited by this paper
• Microtubule assembly dynamics: An attractive target for anticancer drugs

  2008cited by this paper
• The Roles of Therapy-Induced Autophagy and Necrosis in Cancer Treatment

  2007cited by this paper
• Autophagy and Human Disease

  2007cited by this paper
• Mitotic drug targets and the development of novel anti-mitotic anticancer drugs.

  2007cited by this paper
• Bcl-2 Phosphorylation by p38 MAPK

  2006cited by this paper
• Apoptosis regulation in tetraploid cancer cells

  2006influential reference
• Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis.

  2006cited by this paper
• A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization.

  2006influential reference
• Suppression of microtubule dynamics by benomyl decreases tension across kinetochore pairs and induces apoptosis in cancer cells

  2006cited by this paper
• Mitotic checkpoint slippage in humans occurs via cyclin B destruction in the presence of an active checkpoint.

  2006cited by this paper
• Chemotherapeutic approaches for targeting cell death pathways.

  2006cited by this paper
• Mammalian cells lack checkpoints for tetraploidy, aberrant centrosome number, and cytokinesis failure

  2005cited by this paper
• Cell-cycle checkpoints and cancer

  2004cited by this paper
• The contribution of cytotoxic chemotherapy to 5-year survival in adult malignancies.

  2004cited by this paper
• Truncating APC mutations have dominant effects on proliferation, spindle checkpoint control, survival and chromosome stability

  2004influential reference
• Mechanisms and molecules of the mitotic spindle.

  2004cited by this paper
• Synchronized generation of reactive oxygen species with the cell cycle.

  2004cited by this paper
• Crosstalk of the mitotic spindle assembly checkpoint with p53 to prevent polyploidy

  2004cited by this paper
• Microtubules as a target for anticancer drugs

  2004cited by this paper
• Microtubules, microtubule-interfering agents and apoptosis

  2003cited by this paper
• Cdc2-Cyclin B Triggers H3 Kinase Activation of Aurora-A in Xenopus Oocytes*

  2003cited by this paper
• The Dynamic Mobility of Histone H1 Is Regulated by Cyclin/CDK Phosphorylation

  2003cited by this paper
• Regulating mammalian checkpoints through Cdc25 inactivation

  2003cited by this paper
• The p53 network in lung carcinogenesis

  2002influential reference
• Hyperploidy induced by drugs that inhibit formation of microtubule promotes chromosome instability

  2002influential reference
• Cell cycle checkpoint signaling through the ATM and ATR kinases.

  2001cited by this paper
• Microtubule-targeting drugs induce bcl-2 phosphorylation and association with Pin1.

  2001cited by this paper
• The spindle: a dynamic assembly of microtubules and motors

  2001cited by this paper
• Tetraploid state induces p53-dependent arrest of nontransformed mammalian cells in G1.

  2001cited by this paper
• p53 and human cancer: the first ten thousand mutations.

  2000influential reference
• Induction of apoptosis by cancer chemotherapy.

  2000influential reference
• Mitochondria as the central control point of apoptosis.

  2000cited by this paper
• Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β

  2000cited by this paper
• Phosphorylation of Bcl-2 Protein by CDC2 Kinase during G2/M Phases and Its Role in Cell Cycle Regulation*

  2000cited by this paper
• Arsenic targets tubulins to induce apoptosis in myeloid leukemia cells.

  1999cited by this paper
• BCL-2 Is Phosphorylated and Inactivated by an ASK1/Jun N-Terminal Protein Kinase Pathway Normally Activated at G2/M

  1999cited by this paper
• Regulating the onset of mitosis.

  1999cited by this paper
• Involvement of Microtubules in the Regulation of Bcl2 Phosphorylation and Apoptosis through Cyclic AMP-Dependent Protein Kinase

  1998cited by this paper
• Temporal relationship of CDK1 activation and mitotic arrest to cytosolic accumulation of cytochrome C and caspase-3 activity during Taxol-induced apoptosis of human AML HL-60 cells

  1998cited by this paper
• Apoptosis and the dilemma of cancer chemotherapy.

  1997cited by this paper
• Cell death induction by receptors of the TNF family: towards a molecular understanding

  1997cited by this paper
• Taxol-induced apoptosis and phosphorylation of Bcl-2 protein involves c-Raf-1 and represents a novel c-Raf-1 signal transduction pathway.

  1996cited by this paper
• Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21

  1996cited by this paper
• Cancer Cell Cycles

  1996cited by this paper
• Taxol-Induced Mitotic Block Triggers Rapid Onset of a p53-Independent Apoptotic Pathway

  1995cited by this paper
• The genetic basis of cancer.

  1995cited by this paper
• Regulation of the human WEE1Hu CDK tyrosine 15‐kinase during the cell cycle.

  1995influential reference
• Database of p53 gene somatic mutations in human tumors and cell lines.

  1994influential reference
• Anaphase is initiated by proteolysis rather than by the inactivation of maturation-promoting factor.

  1993cited by this paper
• The MO15 gene encodes the catalytic subunit of a protein kinase that activates cdc2 and other cyclin‐dependent kinases (CDKs) through phosphorylation of Thr161 and its homologues.

  1993influential reference
• Expression of the murine homologue of the cell cycle control protein p34cdc2 in T lymphocytes.

  1992cited by this paper
• Checkpoints: controls that ensure the order of cell cycle events.

  1989cited by this paper
• Aphidicolin inhibits DNA synthesis by DNA polymerase alpha and isolated nuclei by a similar mechanism.

  1981cited by this paper
• Hydroxyurea reversal of inhibition and use as a cell-synchronizing agent.

  1967cited by this paper

• Bcl-xL activity influences outcome of the mitotic arrest

  2022cites this paper