Human Monoclonal Autoantibodies to B-Cell Epitopes Outside the Thyroid Peroxidase Autoantibody Immunodominant Region

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Thyroid

• Publication date

  2001-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1089/10507250152039037PMID 11349828
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Human Anti-Thyroid Peroxidase Single-Chain Fragment Variable of Ig Isolated from a Combinatorial Library Assembled In-Cell: Insights into the In Vivo Situation1

  2000cited by this paper
• Autoimmune Response to the Thyroid in Humans: Thyroid Peroxidase-The Common Autoantigenic Denominator

  2000cited by this paper
• Evidence for genetic transmission of thyroid peroxidase autoantibody epitopic "fingerprints".

  1999cited by this paper
• Rarity of autoantibodies to a major autoantigen, thyroid peroxidase, that interact with denatured antigen or with epitopes outside the immunodominant region

  1999influential reference
• Molecular Model, Calcium Sensitivity, and Disease Specificity of a Conformational Thyroperoxidase B-cell Epitope*

  1999cited by this paper
• Relationship between autoantibody epitopic recognition and immunoglobulin gene usage

  1998cited by this paper
• A Conformational B-cell Epitope on the C-terminal End of the Extracellular Part of Human Thyroid Peroxidase*

  1998cited by this paper
• The greater glycan content of recombinant human thyroid peroxidase of mammalian than of insect cell origin facilitates purification to homogeneity of enzymatically protein remaining soluble at high concentration.

  1998cited by this paper
• Only selected light chains combine with a given heavy chain to confer specificity for a model glycopeptide antigen.

  1998cited by this paper
• Analysis of immunoglobulin G kappa antithyroid peroxidase antibodies from different tissues in Hashimoto's thyroiditis.

  1997cited by this paper
• Immunoglobulin Gκ Antithyroid Peroxidase Antibodies in Hashimoto’s Thyroiditis: Epitope-Mapping Analysis1

  1997cited by this paper
• Human anti-nicotinic acetylcholine receptor recombinant Fab fragments isolated from thymus-derived phage display libraries from myasthenia gravis patients reflect predominant specificities in serum and block the action of pathogenic serum antibodies.

  1997cited by this paper
• The epitopic "fingerprint" of thyroid peroxidase-specific Fab isolated from a patient's thyroid gland by the combinatorial library approach resembles that of autoantibodies in the donor's serum.

  1997cited by this paper
• Molecular Analysis of the Antibody Response to Thyroglobulin and Thyroid Peroxidase

  1997influential reference
• Immunoglobulin G kappa antithyroid peroxidase antibodies in Hashimoto's thyroiditis: epitope-mapping analysis.

  1997cited by this paper
• Diverse Fab specific for acetylcholine receptor epitopes from a myasthenia gravis thymus combinatorial library.

  1997cited by this paper
• Thyroid peroxidase autoantibody epitopic ‘fingerprints’ in juvenile Hashimoto's thyroiditis: evidence for conservation over time and in families

  1996cited by this paper
• Influence of the light chain repertoire on immunoglobulin genes encoding thyroid autoantibody Fab from combinatorial libraries.

  1996cited by this paper
• Majority of thyroid peroxidase autoantibodies in patients with autoimmune thyroid disease are directed to a single TPO domain.

  1996cited by this paper
• Unique Autoantibody Epitopes in an Immunodominant Region of Thyroid Peroxidase (*)

  1996cited by this paper
• Determinants of polyreactivity in a large panel of recombinant human antibodies from HIV-1 infection.

  1996cited by this paper
• Synthetic Human Antibodies: Selecting and Evolving Functional Proteins

  1995cited by this paper
• Molecular cloning and characterization of human thyroid peroxidase autoantibodies of lambda light chain type.

  1995cited by this paper
• Thyroid peroxidase autoantibody fingerprints in hypothyroid and euthyroid individuals. I. Cross-sectional study in elderly women.

  1995cited by this paper
• Genetic and epitopic analysis of thyroid peroxidase (TPO) autoantibodies: markers of the human thyroid autoimmune response

  1995influential reference
• Neutralizing recombinant human antibodies to a conformational V2- and CD4-binding site-sensitive epitope of HIV-1 gp120 isolated by using an epitope-masking procedure.

  1995cited by this paper
• Thyroid peroxidase autoantibody fingerprints. II. A longitudinal study in postpartum thyroiditis.

  1995cited by this paper
• Directed selection of recombinant human monoclonal antibodies to herpes simplex virus glycoproteins from phage display libraries.

  1995cited by this paper
• Recombinant thyroid peroxidase-specific autoantibodies. II. Role of individual heavy and light chains in determining epitope recognition.

  1994cited by this paper
• A directory of human germ-line V kappa segments reveals a strong bias in their usage.

  1994cited by this paper
• Recombinant thyroid peroxidase autoantibodies can be used for epitopic "fingerprinting" of thyroid peroxidase autoantibodies in the sera of individual patients.

  1994influential reference
• Nucleotide sequence analysis of natural and combinatorial anti-PDC-E2 antibodies in patients with primary biliary cirrhosis. Recapitulating immune selection with molecular biology.

  1994cited by this paper
• Cloning and characterisation of TPO autoantibodies using combinatorial phage display libraries.

  1994cited by this paper
• A directory of human germ‐line Vχ segments reveals a strong bias in their usage

  1994cited by this paper
• Human organ-specific autoimmune disease. Molecular cloning and expression of an autoantibody gene repertoire for a major autoantigen reveals an antigenic immunodominant region and restricted immunoglobulin gene usage in the target organ.

  1993cited by this paper
• Structure and physical map of 64 variable segments in the 3′ 0.8–megabase region of the human immunoglobulin heavy–chain locus

  1993cited by this paper
• Lack of promiscuity in autoantigen-specific H and L chain combinations as revealed by human H and L chain "roulette".

  1993cited by this paper
• The Vχ genes of the L regions and the repertoire of Vχ gene sequences in the human germ line

  1993cited by this paper
• Differential autoantibody responses to thyroid peroxidase in patients with Graves' disease and Hashimoto's thyroiditis.

  1993cited by this paper
• Combinatorial autoantibodies to dihydrolipoamide acetyltransferase, the major autoantigen of primary biliary cirrhosis.

  1993cited by this paper
• High affinity, thyroid-specific human autoantibodies displayed on the surface of filamentous phage use V genes similar to other autoantibodies.

  1993influential reference
• The V kappa genes of the L regions and the repertoire of V kappa gene sequences in the human germ line.

  1993cited by this paper
• Differing epitope selection of experimentally-induced and natural antibodies to a disease-specific autoantigen, the E2 subunit of pyruvate dehydrogenase complex (PDC-E2).

  1992cited by this paper
• Recognition by recombinant autoimmune thyroid disease-derived Fab fragments of a dominant conformational epitope on human thyroid peroxidase.

  1992cited by this paper
• Identification of localized autoantibody epitopes in thyroid peroxidase.

  1992cited by this paper
• Variable region sequence of a human monoclonal thyroid peroxidase autoantibody.

  1992cited by this paper
• The repertoire of human germline VH sequences reveals about fifty groups of VH segments with different hypervariable loops.

  1992cited by this paper
• Use of recombinant epitopes to study the heterogeneous nature of the autoantibodies against thyroid peroxidase in autoimmune thyroid disease

  1992cited by this paper
• Antibodies from libraries

  1992cited by this paper
• Original and artificial antibodies

  1992cited by this paper
• Mapping of a linear autoantigenic epitope within the human thyroid peroxidase using recombinant DNA techniques.

  1992cited by this paper
• A human Fab fragment specific for thyroid peroxidase generated by cloning thyroid lymphocyte-derived immunoglobulin genes in a bacteriophage lambda library.

  1991cited by this paper
• Physical map of the 3′ region of the human immunoglobulin heavy chain locus: clustering of autoantibody‐related variable segments in one haplotype.

  1991cited by this paper
• Thyroperoxidase, but not the thyrotropin receptor, contains sequential epitopes recognized by autoantibodies in recombinant peptides expressed in the pUEX vector.

  1991cited by this paper
• The human immunoglobulin x locus. Characterization of the duplicated O regions

  1991cited by this paper
• The human immunoglobulin kappa locus. Characterization of the duplicated O regions.

  1991cited by this paper
• Determination at the molecular level of a B-cell epitope on thyroid peroxidase likely to be associated with autoimmune thyroid disease.

  1991cited by this paper
• Mapping of autoantigenic epitopes on recombinant thyroid peroxidase fragments using the polymerase chain reaction.

  1990cited by this paper
• The smaller human VH gene families display remarkably little polymorphism.

  1989cited by this paper
• Thyroid peroxidase and thyroid microsomal autoantibodies.

  1989cited by this paper
• Characterization of two immunoglobulin VH genes that are homologous to human rheumatoid factors.

  1989cited by this paper
• Relationship between immunological structure and biochemical properties of human thyroid peroxidase.

  1989cited by this paper
• The epidemiology of sports-related ocular trauma.

  1988cited by this paper
• The human VK locus. Characterization of a duplicated region encoding 28 different immunoglobulin genes.

  1988cited by this paper
• Epitopes on human acetylcholine receptor defined by monoclonal antibodies and myasthenia gravis sera.

  1988cited by this paper
• Antibodies against denatured and reduced thyroid microsomal antigen in autoimmune thyroid disease.

  1987cited by this paper
• The distribution of microsomal and thyroglobulin antibody activity among the IgG subclasses.

  1984cited by this paper
• Specificities of antibodies to acetylcholine receptors in sera from myasthenia gravis patients measured by monoclonal antibodies.

  1982cited by this paper
• Restrictions in the response to autologous thyroglobulin in the human.

  1980cited by this paper
• THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS

  1949cited by this paper

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  2021cites this paper
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  2019cites this paper
• Using phage display in autoimmunity research.

  2011cites this paper
• Thyroperoxidase, thyroglobulin, Na(+)/I(-) symporter, pendrin in thyroid autoimmunity.

  2011cites this paper
• An Attempt to Induce “Graves' Disease of the Gonads” by Immunizing Mice with the Luteinizing Hormone Receptor Provides Insight into Breaking Tolerance to Self-Antigens

  2011cites this paper
• Epitope recognition patterns of thyroid peroxidase autoantibodies in healthy individuals and patients with Hashimoto's thyroiditis *

  2008cites this paper
• Improved Prediction of Relapse of Graves' Thyrotoxicosis by Combined Determination of TSH Receptor and Thyroperoxidase Antibodies

  2007cites this paper
• Thyroid Peroxidase as an Autoantigen

  2007cites this paper
• Structural and functional aspects of thyroid peroxidase.

  2006cites this paper
• Human monoclonal thyroglobulin autoantibodies: epitopes and immunoglobulin genes.

  2004cites this paper
• Immunoglobulin light chain repertoire in chronic lymphocytic leukemia.

  2004cites this paper
• Thyroid stimulating monoclonal antibodies: overcoming the road blocks and the way forward

  2004cites this paper
• Thyroglobulin-thyroperoxidase autoantibodies are polyreactive, not bispecific: analysis using human monoclonal autoantibodies.

  2003cites this paper
• Localization of the Thyroid Peroxidase Autoantibody Immunodominant Region to a Junctional Region Containing Portions of the Domains Homologous to Complement Control Protein and Myeloperoxidase*

  2002cites this paper
• Human thyroperoxidase folds in one complex B-cell immunodominant region.

  2002cites this paper
• The human anti-thyroid peroxidase autoantibody repertoire in Graves' and Hashimoto's autoimmune thyroid diseases

  2002cites this paper
• Evidence that the Complement Control Protein-Epidermal Growth Factor-Like Domain of Thyroid Peroxidase Lies on the Fringe of the Immunodominant Region Recognized by Autoantibodies

  2002influential citation
• Antibodies to Acetylcholine Receptor in Parous Women with Myasthenia: Evidence for Immunization by Fetal Antigen

  2002cites this paper