Age‐related differences in susceptibility to toxic effects of valproic acid in rats

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Journal of Applied Toxicology

• Publication date

  2008-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/jat.1314PMID 17994530
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Antimicrobial agents

  2008cited by this paper
• An Integrated Study of Acute Effects of Valproic Acid in the Liver Using Metabonomics, Proteomics, and Transcriptomics Platforms

  2006influential reference
• Valproic acid I: time course of lipid peroxidation biomarkers, liver toxicity, and valproic acid metabolite levels in rats.

  2005cited by this paper
• How children's responses to drugs differ from adults.

  2005cited by this paper
• Gastric emptying in children.

  2004cited by this paper
• CHILDREN's SUSCEPTIBILITY TO CHEMICALS: A REVIEW BY DEVELOPMENTAL STAGE

  2004cited by this paper
• Performance characteristics of a magnetic Stirling cooler This article is a U.S. Government work and is in the public domain in the U.S.A.

  2002cited by this paper
• Children Versus Adults: Pharmacokinetic and Adverse‐Effect Differences

  2002cited by this paper
• In vitro evaluation of valproic acid as an inhibitor of human cytochrome P450 isoforms: preferential inhibition of cytochrome P450 2C9 (CYP2C9).

  2001cited by this paper
• Incidence of adverse drug reactions in paediatric in/out-patients: a systematic review and meta-analysis of prospective studies.

  2001cited by this paper
• Mechanisms underlying Children's susceptibility to environmental toxicants.

  2000cited by this paper
• The effects of valproate on the arachidonic acid metabolism of rat brain microvessels and of platelets.

  2000cited by this paper
• Analgesics, Antipyretics, and Antiinflammatory Agents

  2000cited by this paper
• Platelet count and function in children receiving sodium valproate.

  1999cited by this paper
• Valproate population pharmacokinetics in children

  1999influential reference
• Lamotrigine‐Associated Rash: Risk/Benefit Considerations in Adults and Children

  1999cited by this paper
• Adverse drug reactions

  1998cited by this paper
• The incidence of drug‐related problems as a cause of hospital admissions in children

  1998cited by this paper
• Onset of xenobiotic metabolism in children: toxicological implications.

  1998cited by this paper
• Fortnightly review: Adverse drug reactions

  1998cited by this paper
• Gastric emptying in children.

  1998cited by this paper
• Pharmacogenetics in pediatrics. Implications for practice.

  1997cited by this paper
• Valproic acid hepatic fatalities. III. U.S. experience since 1986

  1996cited by this paper
• Principles of Neonatal Pharmacology

  1996cited by this paper
• Inhibition of mitochondrial beta-oxidation as a mechanism of hepatotoxicity.

  1995cited by this paper
• Blood dyscrasias with carbamazepine and valproate: a pharmacoepidemiological study of 2,228 patients at risk.

  1995cited by this paper
• Valproate‐mediated disturbances of hemostasis

  1994cited by this paper
• Thrombocytopenia Secondary to High Valproate Levels in Children With Epilepsy

  1994cited by this paper
• Valproic acid pharmacokinetics in children. IV. Effects of age and antiepileptic drugs on protein binding and intrinsic clearance

  1993cited by this paper
• Changes in red blood cells with valproate therapy

  1993cited by this paper
• Hematologic Manifestations of Long‐Term Valproate Therapy

  1993cited by this paper
• [Adverse effects of valproic acid in epileptic infants and adolescents].

  1991cited by this paper
• Differences in the developmental expression of rabbit cytochromes P-450 2E1 and 2E2.

  1991cited by this paper
• Small intestinal length: a factor essential for gut adaptation.

  1991cited by this paper
• The High Incidence of Valproate Hepatotoxicity in Infants May Relate to Familial Metabolic Defects

  1990cited by this paper
• Valproic acid hepatic fatalities.

  1989cited by this paper
• Female-predominant rat hepatic P-450 forms j (IIE1) and 3 (IIA1) are under hormonal regulatory controls distinct from those of the sex-specific P-450 forms.

  1989cited by this paper
• Valproate-Associated Hepatotoxicity and its Biochemical Mechanisms

  1988cited by this paper
• Valproic acid hepatic fatalities

  1987cited by this paper
• Goodman & Gilman's The Pharmacological Basis of Therapeutics

  1985cited by this paper
• Immunoquantification of epoxide hydrolase and cytochrome P-450 isozymes in fetal and adult human liver microsomes.

  1985cited by this paper
• The Hepatotoxicity of Valproic Acid and Its Metabolites in Rats. I. Toxicologic, Biochemical and Histopathologic Studies

  1984cited by this paper
• Aspects of the metabolism of valproic acid.

  1984cited by this paper
• Valproate‐induced hepatic steatogenesis in rats

  1982cited by this paper
• Drug-metabolizing enzymes in human foetal liver: partial resolution of multiple cytochromes P 450.

  1982cited by this paper
• Mechanism of anticonvulsant action of valproate

  1982cited by this paper
• Sodium Di‐N‐Propylacetate (DPA) in the Treatment of Epilepsy:A Review

  1975cited by this paper
• The Gastric Function

  1920cited by this paper

• Potential Protective Role of Radicut in Valproic Acid-Induced Oxidative Stress in Rat Spleen

  2024cites this paper
• Hepatotoxic Evaluation of N-(2-Hydroxyphenyl)-2-Propylpentanamide: A Novel Derivative of Valproic Acid for the Treatment of Cancer

  2023cites this paper
• A review of the mechanisms of valproate-induced liver injury with an emphasis on the role of reactive metabolites discovered by Tom Baillie

  2023cites this paper
• Potential of the zebrafish (Danio rerio) embryo test to discriminate between chemicals of similar molecular structure—a study with valproic acid and 14 of its analogues

  2022cites this paper
• Application of high-throughput transcriptomics for mechanism-based biological read-across of short-chain carboxylic acid analogues of valproic acid.

  2022influential citation
• Response of the critically endangered Przewalski's gazelle (Procapra przewalskii) to selenium deprived environment.

  2021cites this paper
• A read-across case study on chronic toxicity of branched carboxylic acids (1): Integration of mechanistic evidence from new approach methodologies (NAMs) to explore a common mode of action.

  2021cites this paper
• The effect of hyperglycinemic treatment in captive-bred Vervet monkeys (Chlorocebus aethiops)

  2019cites this paper
• Age-Related Diazinon Toxicity Impact on Blood Glucose, Lipid Profile and Selected Biochemical Indices in Male Rats

  2019cites this paper
• Aqueous Calyx Extract of Hibiscus sabdariffa: Impact on Growth, Gastrointestinal Morphometry, Liver and Clinical Chemistry of Suckling Rats

  2017cites this paper
• Hyperglycinemia in captive-bred vervet monkeys with cataracts: genetic dynamics and associations

  2017cites this paper
• Investigation of the Effects of Edaravone on Valproic Acid Induced Tissue Damage in Pancreas

  2017cites this paper
• Effects of administration of Hibiscus sabdariffa aqueous calyx extracts on neonatal programming of metabolic dysfunction

  2015cites this paper
• Effects of crude leaf extracts of Ficus thonningii on growth, gastrointestinal morphometrry and clinical biochemistry of suckling Sprague Dawley rats

  2014cites this paper
• Evidence for a potential protective effect of carnitine-pantothenic acid co-treatment on valproic acid-induced hepatotoxicity

  2014cites this paper
• Impact of trichostatin A and sodium valproate treatment on post-stroke neurogenesis and behavioral outcomes in immature mice

  2013cites this paper
• Discovery of early urinary biomarkers in preclinical study of gentamicin-induced kidney injury and recovery in rats

  2012cites this paper
• Metabolomics in Systems Toxicology: Towards Personalized Medicine

  2011cites this paper
• Study of valproic acid-induced endogenous and exogenous metabolite alterations using LC-MS-based metabolomics.

  2010cites this paper
• Are rats the appropriate experimental model to understand age-related renal drug metabolism and toxicity?

  2010cites this paper
• Metabolomics approaches for discovering biomarkers of drug-induced hepatotoxicity and nephrotoxicity.

  2010cites this paper
• Single valproic acid treatment inhibits glycogen and RNA ribose turnover while disrupting glucose-derived cholesterol synthesis in liver as revealed by the [U-13C6]-d-glucose tracer in mice

  2009cites this paper
• Genomic and metabolomic advances in the identification of disease and adverse event biomarkers.

  2009cites this paper
• Studies of acetaminophen and metabolites in urine and their correlations with toxicity using metabolomics.

  2009cites this paper
• Age‐related differences in susceptibility to cisplatin‐induced renal toxicity

  2009cites this paper
• Evaluations of the trans-sulfuration pathway in multiple liver toxicity studies.

  2009cites this paper
• Differences in Immunolocalization of Kim-1, RPA-1, and RPA-2 in Kidneys of Gentamicin-, Cisplatin-, and Valproic Acid-Treated Rats: Potential Role of iNOS and Nitrotyrosine

  2009cites this paper
• International Journal of Nanomedicine Dovepress in Vivo Biodistribution and Biological Impact of Injected Carbon Nanotubes Using Magnetic Resonance Techniques

  year unknowncites this paper