Pbx1 is a downstream target of Evi-1 in hematopoietic stem/progenitors and leukemic cells

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Oncogene

• Publication date

  2009-12-10

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/onc.2009.288PMID 19767769
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Pathogenetic significance of ecotropic viral integration site‐1 in hematological malignancies

  2009cited by this paper
• EVI1 Impairs myelopoiesis by deregulation of PU.1 function.

  2009cited by this paper
• Evi‐1 promotes para‐aortic splanchnopleural hematopoiesis through up‐regulation of GATA‐2 and repression of TGF‐b signaling

  2008cited by this paper
• AML1-Evi-1 specifically transforms hematopoietic stem cells through fusion of the entire Evi-1 sequence to AML1

  2008cited by this paper
• Significant increase of self-renewal in hematopoietic cells after forced expression of EVI1.

  2008cited by this paper
• Identification of Pbx1, a potential oncogene, as a Notch3 target gene in ovarian cancer.

  2008cited by this paper
• Pbx1 regulates self-renewal of long-term hematopoietic stem cells by maintaining their quiescence.

  2008cited by this paper
• High EVI1 levels predict adverse outcome in acute myeloid leukemia: prevalence of EVI1 overexpression and chromosome 3q26 abnormalities underestimated.

  2008cited by this paper
• AML1 mutations induced MDS and MDS/AML in a mouse BMT model.

  2008cited by this paper
• Pre-B-cell leukemia transcription factor 1 regulates expression of valosin-containing protein, a gene involved in cancer growth.

  2007cited by this paper
• Trib1 and Evi1 cooperate with Hoxa and Meis1 in myeloid leukemogenesis.

  2007cited by this paper
• Pre-B-cell leukemia transcription factor 1 is a major target of promyelocytic leukemia zinc-finger-mediated melanoma cell growth suppression

  2007cited by this paper
• Evi1 is a survival factor which conveys resistance to both TGFβ- and taxol-mediated cell death via PI3K/AKT

  2006influential reference
• Pre-B-cell leukemia transcription factor 1 is a major target of promyelocytic leukemia zinc-finger-mediated melanoma cell growth suppression

  2006cited by this paper
• Chromatin immunoprecipitation and microarray-based analysis of protein location

  2006cited by this paper
• Oncogenic transcription factor Evi1 regulates hematopoietic stem cell proliferation through GATA‐2 expression

  2005influential reference
• AP-2α selectively regulates fragile X mental retardation-1 gene transcription during embryonic development

  2005cited by this paper
• Identification of Binding Sites of EVI1 in Mammalian Cells*

  2005cited by this paper
• AP-2alpha selectively regulates fragile X mental retardation-1 gene transcription during embryonic development.

  2005cited by this paper
• Oligomerization of Evi-1 regulated by the PR domain contributes to recruitment of corepressor CtBP

  2005cited by this paper
• Prognostically useful gene-expression profiles in acute myeloid leukemia.

  2004influential reference
• Abnormalities of caudal pharyngeal pouch development in Pbx1 knockout mice mimic loss of Hox3 paralogs.

  2004cited by this paper
• Pbx1 regulates nephrogenesis and ureteric branching in the developing kidney.

  2003cited by this paper
• High EVI1 expression predicts poor survival in acute myeloid leukemia: a study of 319 de novo AML patients.

  2003cited by this paper
• Transformation of Bone Marrow B-Cell Progenitors by E2A-HLF Requires Coexpression of BCL-2

  2002cited by this paper
• Pbx1 inactivation disrupts pancreas development and in Ipf1-deficient mice promotes diabetes mellitus

  2002cited by this paper
• Identification of Novel Functional Regions Important for the Activity of HOXB7 in Mammalian Cells1

  2001cited by this paper
• Requirement for Pbx1 in skeletal patterning and programming chondrocyte proliferation and differentiation.

  2001cited by this paper
• The corepressor CtBP interacts with Evi-1 to repress transforming growth factor beta signaling.

  2001cited by this paper
• HoxB8 requires its Pbx-interaction motif to block differentiation of primary myeloid progenitors and of most cell line models of myeloid differentiation

  2001cited by this paper
• The Hox cofactor and proto-oncogene Pbx1 is required for maintenance of definitive hematopoiesis in the fetal liver.

  2001cited by this paper
• HoxA9-mediated immortalization of myeloid progenitors requires functional interactions with TALE cofactors Pbx and Meis

  2000cited by this paper
• The Evi‐1 oncoprotein inhibits c‐Jun N‐terminal kinase and prevents stress‐induced cell death

  2000cited by this paper
• The oncoprotein Evi-1 represses TGF-beta signalling by inhibiting Smad3.

  1998cited by this paper
• Cellular proliferation and transformation induced by HOXB4 and HOXB3 proteins involves cooperation with PBX1

  1998cited by this paper
• Structurally altered Evi-1 protein generated in the 3q21q26 syndrome.

  1996cited by this paper
• Intergenic splicing of MDS1 and EVI1 occurs in normal tissues as well as in myeloid leukemia and produces a new member of the PR domain family.

  1996influential reference
• The Role of HOX Homeobox Genes in Normal and Leukemic Hematopoiesis

  1996cited by this paper
• The specificity of homeotic gene function

  1995cited by this paper
• The carboxyl domain of zinc fingers of the Evi-1 myeloid transforming gene binds a consensus sequence of GAAGATGAG.

  1994cited by this paper
• Evi-1 raises AP-1 activity and stimulates c-fos promoter transactivation with dependence on the second zinc finger domain.

  1994influential reference
• Identification of a breakpoint cluster region 3' of the ribophorin I gene at 3q21 associated with the transcriptional activation of the EVI1 gene in acute myelogenous leukemias with inv(3)(q21q26).

  1994cited by this paper
• Identification of AML-1 and the (8;21) translocation protein (AML-1/ETO) as sequence-specific DNA-binding proteins: the runt homology domain is required for DNA binding and protein-protein interactions

  1993influential reference
• Four of the seven zinc fingers of the Evi-1 myeloid-transforming gene are required for sequence-specific binding to GA(C/T)AAGA(T/C)AAGATAA

  1993influential reference
• The human t(1;19) translocation in pre-B ALL produces multiple nuclear E2A-Pbx1 fusion proteins with differing transforming potentials.

  1991cited by this paper
• Evi-1, a murine zinc finger proto-oncogene, encodes a sequence-specific DNA-binding protein

  1991influential reference
• Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor.

  1990cited by this paper
• A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL.

  1990cited by this paper
• Clinical correlations of the 3q21;q26 cytogenetic anomaly. A leukemic or myelodysplastic syndrome with preserved or increased platelet production and lack of response to cytotoxic drug therapy

  1985cited by this paper

• CRISPR-Cas9-mediated deletion enhancer of MECOM play a tumor suppressor role in ovarian cancer

  2024cites this paper
• Clinical significance of dynamic monitoring of EVI1 gene expression in pediatric acute myeloid leukemia

  2024cites this paper
• Acute myeloid leukemia (AML) with chromosome 3 inversion: biology, management, and clinical outcome

  2024cites this paper
• A novel mutation in MECOM affects MPL regulation in vitro and results in thrombocytopenia and bone marrow failure

  2023cites this paper
• Mosaic chromosomal alterations is associated with increased lung cancer risk: insight from the INTEGRAL-ILCCO cohort analysis.

  2023cites this paper
• Analysis of core mutation and TET2/ASXL1 mutations DNA methylation profile in myelodysplastic syndrome

  2023cites this paper
• Regulation and signaling pathways in cancer stem cells: implications for targeted therapy for cancer

  2023cites this paper
• EVI1-mediated Programming of Normal and Malignant Hematopoiesis

  2023cites this paper
• Comprehensive overview of the role of PBX1 in mammalian kidneys

  2023cites this paper
• Hematopoietic Stem Cell Factors: Their Functional Role in Self-Renewal and Clinical Aspects

  2022influential citation
• Targeting histone methylation to reprogram the transcriptional state that drives survival of drug-tolerant myeloid leukemia persisters

  2022cites this paper
• CRISPR-mediated MECOM depletion retards tumor growth by reducing cancer stem cell properties in lung squamous cell carcinoma

  2022cites this paper
• EVI1 dysregulation: impact on biology and therapy of myeloid malignancies

  2021cites this paper
• EVI1 overexpression promotes ovarian cancer progression by regulating estrogen signaling.

  2021cites this paper
• PBX1: a key character of the hallmarks of cancer

  2021cites this paper
• Myeloid neoplasms associated with t(3;12)(q26.2;p13) are clinically aggressive, show myelodysplasia, and frequently harbor chromosome 7 abnormalities

  2020cites this paper
• Nuclear genetic regulation of human mitochondrial RNA modification

  2019cites this paper
• Prognostic significance of the EVI1 gene expression in patients with acute myeloid leukemia: a meta-analysis

  2019cites this paper
• Oncogenic heterogeneous nuclear ribonucleoprotein D-like modulates the growth and imatinib response of human chronic myeloid leukemia CD34+ cells via pre-B-cell leukemia homeobox 1

  2019cites this paper
• Two effects of GATA2 enhancer repositioning by 3q chromosomal rearrangements

  2019cites this paper
• EVI1 overexpression reprograms hematopoiesis via upregulation of Spi1 transcription

  2018cites this paper
• The reciprocal link between EVI1 and miRNAs in human malignancies.

  2018cites this paper
• Reprogramming acute myeloid leukemia into sensitivity for retinoic-acid-driven differentiation.

  2017cites this paper
• The MDS and EVI1 complex locus (MECOM) isoforms regulate their own transcription and have different roles in the transformation of hematopoietic stem and progenitor cells.

  2017cites this paper
• Loss of p53 induces leukemic transformation in a murine model of Jak2 V617F-driven polycythemia vera

  2017cites this paper
• Overexpression of oncoprotein ecotropic viral integration site 1 is an independent prognostic biomarker of gastric cancer

  2017cites this paper
• Review: Aberrant EVI1 expression in acute myeloid leukaemia

  2016cites this paper
• Reduction in Cell Viability and in Homeobox Protein Levels Following in Vitro Exposure to δ-tocopherol in Acute Myeloid Leukemia

  2016cites this paper
• Internal Tandem Duplication in FLT3 Attenuates Proliferation and Regulates Resistance to the FLT3 Inhibitor AC220 by Modulating p21Cdkn1a and Pbx1 in Hematopoietic Cells

  2016cites this paper
• The central nervous system microenvironment influences the leukemia transcriptome and enhances leukemia chemo-resistance

  2016cites this paper
• Expression of MECOM is associated with unfavorable prognosis in glioblastoma multiforme

  2016cites this paper
• expression of MecOM is associated with unfavorable prognosis in glioblastoma multiforme

  2016cites this paper
• EVI1 promotes tumor growth via transcriptional repression of MS4A3

  2015cites this paper
• 3q26/EVI1 rearrangements in myeloid hemopathies: a cytogenetic review.

  2015cites this paper
• Evi1 defines leukemia-initiating capacity and tyrosine kinase inhibitor resistance in chronic myeloid leukemia

  2014cites this paper
• Survivin Modulates Genes with Divergent Molecular Functions and Regulates Proliferation of Hematopoietic Stem Cells through Evi-1

  2014influential citation
• The role of EVI1 in myeloid malignancies.

  2014cites this paper
• Physical and functional interaction of the proto-oncogene EVI1 and tumor suppressor gene HIC1 deregulates Bcl-xL mediated block in apoptosis.

  2014cites this paper
• A remote GATA2 hematopoietic enhancer drives leukemogenesis in inv(3)(q21;q26) by activating EVI1 expression.

  2014cites this paper
• Global Identification of EVI1 Target Genes in Acute Myeloid Leukemia

  2013cites this paper
• Phosphorylation of the Leukemic Oncoprotein EVI1 on Serine 196 Modulates DNA Binding, Transcriptional Repression and Transforming Ability

  2013influential citation
• The shortest isoform of C/EBPβ, liver inhibitory protein (LIP), collaborates with Evi1 to induce AML in a mouse BMT model.

  2013cites this paper
• Evolution of Mammalian KELL Blood Group Glycoproteins and Genes (KEL): Evidence for a Marsupial Origin from an Ancestral M13 Type II Endopeptidase Gene

  2013cites this paper
• Identification of long-term repopulating hematopoietic stem cells by Evi1

  2013cites this paper
• An MLL-dependent network sustains hematopoiesis

  2013cites this paper
• Genetic modeling of the Hippo pathway in hematopoietic stem cells

  2012cites this paper
• The Prdm family: expanding roles in stem cells and development

  2012cites this paper
• HIPPO PATHWAY IN HEMATOPOIETIC STEM CELLS

  2012cites this paper
• Ecotropic viral integration site 1, stem cell self‐renewal and leukemogenesis

  2012cites this paper
• Regulation of Hematopoietic Stem Cell Fate: Self-Renewal, Quiescence and Survival

  2012cites this paper
• Loss of AML 1 / Runx 1 accelerates the development of MLL-ENL leukemia through down-regulation of p 19 ARF *

  2011cites this paper
• Key roles of histone methyltransferase and demethylase in leukemogenesis

  2011cites this paper
• EVI 1 ( ecotropic viral integration site 1 ( EVI 1 ) and myelodysplastic syndrome 1 ( MDS 1 )-EVI 1 )

  2011cites this paper
• Acetylation of the Proto-Oncogene EVI1 Abrogates Bcl-xL Promoter Binding and Induces Apoptosis

  2011cites this paper
• Evi1 is essential for hematopoietic stem cell self-renewal, and its expression marks hematopoietic cells with long-term multilineage repopulating activity

  2011cites this paper
• Evi1 forms a bridge between the epigenetic machinery and signaling pathways

  2011cites this paper
• Control of EVI-1 oncogene expression in metastatic breast cancer cells through microRNA miR-22

  2011cites this paper
• interactions with polycomb proteins Evi1 represses PTEN expression and activates PI3K/AKT/mTOR via

  2011cites this paper
• EVI1‐mediated down regulation of MIR449A is essential for the survival of EVI1 positive leukaemic cells

  2011cites this paper
• Effects of Herba Epimedii and Fructus Ligustri lucidi on the transcription factors in hypothalamus of aged rats

  2011cites this paper
• EVI1 up-regulates the stress responsive gene SIRT1 which triggers deacetylation and degradation of EVI1.

  2011cites this paper
• Evi1 represses PTEN expression and activates PI3K/AKT/mTOR via interactions with polycomb proteins.

  2011cites this paper
• Loss of AML1/Runx1 accelerates the development of MLL-ENL leukemia through down-regulation of p19ARF.

  2011cites this paper
• EVI1 overexpression in distinct subtypes of pediatric acute myeloid leukemia

  2010cites this paper
• Unbiased, Genome-Wide In Vivo Mapping of Transcriptional Regulatory Elements Reveals Sex Differences in Chromatin Structure Associated with Sex-Specific Liver Gene Expression

  2010cites this paper