Nutrition and exercise can attenuate inflammatory and psychobiological changes in hypoxia

Abstract Exposure to hypoxia causes damage in several physiological systems, whose tissues are dependent on the O 2 supply. Recently, there has been growing attention on the immunosuppressive and inflammatory potential of the hypoxia, including stimulation, nuclear factor kappa B pathway in macrophages and Th2 response from lymphocytes. These changes may result in transient immunosuppression and happen at the same time to worsening of cognition and other psychobiological aspects. Furthermore, exercise and nutrition, especially glutamine supplementation may provide important role, not pharmacological partially reversing the effects of hypoxia. In fact, recent studies show that moderate exercise can improve cognition in people exposed to hypoxia while the exercise associated with glutamine supplementation can reverse the increase in inflammatory markers and the Th1/Th2 balance. This review aims to bring the light of the discussion about nonpharmacological ways to prevent the effects of hypoxia on the connection between the immune system and the central nervous system.

• Publication year

  2017

• Venue

  Asian pacific Journal of Tropical Biomedicine

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1016/J.APJTB.2016.11.005
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Physiological and cytokine response to acute exercise under hypoxic conditions: a study pilot.

  2016cited by this paper
• Acute physical exercise under hypoxia improves sleep, mood and reaction time.

  2016cited by this paper
• Dietary glutamine supplementation partly reverses impaired macrophage function resulting from overload training in rats.

  2015cited by this paper
• Preview : Published ahead of advance online publication Exercise , immune function and respiratory infection : An update on the influence of training and environmental stress

  2015cited by this paper
• Acute hypoxic gas breathing severely impairs cognition and task learning in humans.

  2015cited by this paper
• Environmental and Metabolic Sensors That Control T Cell Biology

  2015cited by this paper
• Heat stress-induced memory impairment is associated with neuroinflammation in mice

  2015cited by this paper
• Neuroinflammation and Neuroimmune Dysregulation after Acute Hypoxic-Ischemic Injury of Developing Brain

  2015cited by this paper
• Exercise and fitness modulate cognitive function in older adults.

  2015cited by this paper
• Effect of Ca2EDTA on Zinc Mediated Inflammation and Neuronal Apoptosis in Hippocampus of an In Vivo Mouse Model of Hypobaric Hypoxia

  2014cited by this paper
• Inflammation and insulin/IGF-1 resistance as the possible link between obesity and neurodegeneration.

  2014cited by this paper
• Carbohydrate and glutamine supplementation modulates the Th1/Th2 balance after exercise performed at a simulated altitude of 4500 m.

  2014cited by this paper
• Brazilian Green Propolis Suppresses the Hypoxia-Induced Neuroinflammatory Responses by Inhibiting NF-κB Activation in Microglia

  2013cited by this paper
• Effect of glutamine on apoptosis of intestinal epithelial cells of severe acute pancreatitis rats receiving nutritional support in different ways.

  2013cited by this paper
• High Altitude Impairs In Vivo Immunity in Humans

  2013cited by this paper
• Guanfacine is an effective countermeasure for hypobaric hypoxia-induced cognitive decline.

  2013cited by this paper
• Can High Altitude Influence Cytokines and Sleep?

  2013cited by this paper
• Hypoxia and hypoxia-inducible factors as regulators of T cell development, differentiation, and function

  2013cited by this paper
• Chronic Intermittent Hypoxia Exerts CNS Region-Specific Effects on Rat Microglial Inflammatory and TLR4 Gene Expression

  2013cited by this paper
• Schizophrenia, poor physical health and physical activity: evidence-based interventions are required to reduce major health inequalities

  2013cited by this paper
• Neurogenesis, inflammation and behavior.

  2013cited by this paper
• New Paradigm in Nutrition Support: Using Evidence to Drive Practice

  2012cited by this paper
• Respiratory health of elite athletes – preventing airway injury: a critical review

  2012cited by this paper
• Effects of 4:1 carbohydrate/protein solution versus a carbohydrate-alone solution on IL-6, TNF-α, and cortisol during prolonged cycling in hot environmental conditions

  2012cited by this paper
• Hypoxia/Reoxygenation Impairs Memory Formation via Adenosine-Dependent Activation of Caspase 1

  2012cited by this paper
• Effects of neonatal enteral glutamine supplementation on cognitive, motor and behavioural outcomes in very preterm and/or very low birth weight children at school age

  2012cited by this paper
• Hypoxia-inducible factors: crosstalk between inflammation and metabolism.

  2012cited by this paper
• Hypoxia and inflammation.

  2011cited by this paper
• Importance of exercise immunology in health promotion

  2011cited by this paper
• Position statement. Part two: Maintaining immune health.

  2011cited by this paper
• Impact of Short-Term Systemic Hypoxia on Phagocytosis, Cytokine Production, and Transcription Factor Activation in Peripheral Blood Cells

  2011cited by this paper
• Position statement. Part one: Immune function and exercise.

  2011cited by this paper
• S100B Profiles and Cognitive Function at High Altitude

  2010cited by this paper
• Role of Oxidative Stress and Inflammation in Hypoxia-Induced Cerebral Edema: A Molecular Approach

  2010influential reference
• Influence of High Altitude Exposure on the Immune System: A Review

  2010cited by this paper
• Immunonutrition support for athletes.

  2008cited by this paper
• The Immunological and Metabolic Responses to Exercise of Varying Intensities in Normoxic and Hypoxic Environments

  2008cited by this paper
• Neuroimmunomodulation during Exercise: Role of Catecholamines as ‘Stress Mediator’ and/or ‘Danger Signal’ for the Innate Immune Response

  2007cited by this paper
• CCR2 modulates inflammatory and metabolic effects of high-fat feeding.

  2006cited by this paper
• Cytokine responses at high altitude: effects of exercise and antioxidants at 4300 m.

  2006cited by this paper
• Living high–training low altitude training: effects on mucosal immunity

  2005cited by this paper
• Exercise as a Time-conditioning Effector in Chronic Disease: a Complementary Treatment Strategy

  2004cited by this paper
• Exercise as a Time-conditioning Effector in Chronic Disease: a Complementary Treatment Strategy

  2004cited by this paper
• Leukocyte counts and neutrophil activity during 4 h of hypocapnic hypoxia equivalent to 4000 m.

  2004cited by this paper
• Effects of An Oral Mixture Containing Glycine, Glutamine and Niacin on Memory, GH and IGF-I Secretion in Middle-aged and Elderly Subjects

  2003cited by this paper
• The Role of Dietary Supplementation with L-Glutamine in Inflammatory Mediator Release and Intestinal Injury in Hypoxia/Reoxygenation-Induced Experimental Necrotizing Enterocolitis

  2003cited by this paper
• Exercise and hypoxia: effects on leukocytes and interleukin-6-shared mechanisms?

  2002cited by this paper
• Interleukin-6 response to exercise and high-altitude exposure: influence of α-adrenergic blockade

  2001cited by this paper
• Glutamine reduces cytokine release, organ damage, and mortality in a rat model of endotoxemia.

  2001cited by this paper
• High altitude increases circulating interleukin-6, interleukin-1 receptor antagonist and C-reactive protein.

  2000cited by this paper
• Continuous and intermittent exposure to the hypoxia of altitude: implications for glutamine metabolism and exercise performance

  2000cited by this paper
• Receptor‐Mediated Local Fine‐Tuning by Noradrenergic Innervation of Neuroendocrine and Immune Systems a

  1998cited by this paper
• Effects of acute moderate hypoxia on human performance of arithmetic.

  1998cited by this paper
• Hypoxemia increases serum interleukin-6 in humans

  1997cited by this paper
• Carbohydrate affects natural killer cell redistribution but not activity after running.

  1997cited by this paper

• Metabolic responses to acute and prolonged hypoxic exposure

  2017cites this paper