Constitutively active G protein-coupled receptor mutants block dictyostelium development.

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Molecular Biology of the Cell

• Publication date

  2004-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1091/MBC.E04-06-0456PMID 15574880PMCID PMC545893
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2003influential reference
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  1997influential reference
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• Molecular genetics of signal transduction in Dictyostelium.

  1996influential reference
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  1994influential reference
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  1993cited by this paper
• Randomization of genes by PCR mutagenesis.

  1992cited by this paper
• Multiple cyclic AMP receptors are linked to adenylyl cyclase in Dictyostelium.

  1992influential reference
• Molecular genetic analysis of two Gα protein subunits in Dictyostelium

  1991cited by this paper
• Molecular genetic analysis of two G alpha protein subunits in Dictyostelium.

  1991cited by this paper
• Overexpression of the cAMP receptor 1 in growing Dictyostelium cells.

  1991cited by this paper
• A chemoattractant receptor controls development in Dictyostelium discoideum.

  1988cited by this paper
• Ligand-induced phosphorylation of the cAMP receptor from Dictyostelium discoideum.

  1988cited by this paper
• Different molecular mechanisms for cAMP regulation of gene expression during Dictyostelium development.

  1987cited by this paper
• Cyclic AMP regulation of early gene expression in Dictyostelium discoideum: mediation via the cell surface cyclic AMP receptor

  1987cited by this paper
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  1987influential reference
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  1986influential reference
• cAMP activates adenylate and guanylate cyclase of Dictyostelium discoideum cells by binding to different classes of cell-surface receptors. A study with extracellular Ca2+.

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  1980influential reference
• Biochemical properties of hormone-sensitive adenylate cyclase.

  1980cited by this paper
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  1980influential reference
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