CircRNA_000543 knockdown sensitizes nasopharyngeal carcinoma to irradiation by targeting miR-9/platelet-derived growth factor receptor B axis.

Radiation therapy is the mainstay of salvage therapy for nasopharyngeal carcinoma (NPC). However, radiation therapy efficacy is limited by radioresistance that can cause local recurrence and distant metastases. Circular RNAs (circRNAs) have been involved in radioresistant esophageal cancer cells. In this study, we aim to investigate the role of circRNAs in the radioresistant NPC. Human circRNA array was performed in radioresistant and radiosensitive NPC samples to screen the differentially expressed circRNAs. We found that circRNA_000543 expression was upregulated in NPC tissues compared adjacent tissues, and was higher in radioresistant samples than in radiosensitive NPC samples. NPC patients with high circRNA_000543 expression displayed poorer overall survival compared with the patients with low circRNA_000543. Further investigations demonstrated that circRNA_000543 knockdown sensitized NPC cells by targeting miR-9/platelet-derived growth factor receptor B (PDGFRB) axis. CircRNA_000543 may be a potential therapeutic target for radioresistant NPC.

• Publication year

  2019

• Venue

  Biochemical and Biophysical Research Communications - BBRC

• Publication date

  2019-05-14

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.bbrc.2019.03.126PMID 30928094
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• miR-9 Enhances the Chemosensitivity of AML Cells to Daunorubicin by Targeting the EIF5A2/MCL-1 Axis

  2019cited by this paper
• miR‐9: From function to therapeutic potential in cancer

  2019cited by this paper
• miR-9-5p inhibits pancreatic cancer cell proliferation, invasion and glutamine metabolism by targeting GOT1.

  2019cited by this paper
• Circular RNA: a novel biomarker and therapeutic target for human cancers

  2019cited by this paper
• Function and clinical significance of circRNAs in solid tumors

  2018cited by this paper
• Upregulation of circRNA_0000285 serves as a prognostic biomarker for nasopharyngeal carcinoma and is involved in radiosensitivity

  2018cited by this paper
• CircRNA_0109291 regulates cell growth and migration in oral squamous cell carcinoma and its clinical significance

  2018cited by this paper
• MiR-9-5p promotes cell growth and metastasis in non-small cell lung cancer through the repression of TGFBR2.

  2017cited by this paper
• CircRNA: functions and properties of a novel potential biomarker for cancer

  2017cited by this paper
• MicroRNA-518b functions as a tumor suppressor in glioblastoma by targeting PDGFRB

  2017cited by this paper
• MiR-125b Increases Nasopharyngeal Carcinoma Radioresistance by Targeting A20/NF-κB Signaling Pathway

  2017cited by this paper
• miR-9 and miR-200 Regulate PDGFRβ-Mediated Endothelial Differentiation of Tumor Cells in Triple-Negative Breast Cancer.

  2016cited by this paper
• Biomarkers for enhancing the radiosensitivity of nasopharyngeal carcinoma

  2015cited by this paper
• Nasopharyngeal carcinoma.

  2015cited by this paper
• Up-regulation of miR-9 expression predicate advanced clinicopathological features and poor prognosis in patients with hepatocellular carcinoma

  2014cited by this paper
• Investigational platelet-derived growth factor receptor kinase inhibitors in breast cancer therapy

  2014cited by this paper
• miR-9 targets CXCR4 and functions as a potential tumor suppressor in nasopharyngeal carcinoma.

  2014cited by this paper
• MicroRNA-9

  2011cited by this paper
• MicroRNA-9 is an activation-induced regulator of PDGFR-beta expression in cardiomyocytes.

  2011cited by this paper
• Nasopharyngeal Carcinoma

  1966cited by this paper

• Ferroptosis and cuproptosis in head and neck squamous cell carcinoma: interconnected mechanisms and therapeutic implications.

  2026cites this paper
• A fishnet between nasopharyngeal carcinoma and resistance: the competing endogenous RNA network

  2025cites this paper
• Emerging roles of circular RNAs in nasopharyngeal carcinoma: functions and implications

  2024cites this paper
• Research progress on the role and mechanism of circular RNA in drug resistance of head and neck squamous cell carcinoma

  2024cites this paper
• Knockdown of circ_0005615 enhances the radiosensitivity of colorectal cancer by regulating the miR-665/NOTCH1 axis

  2023cites this paper
• CircRNAs: versatile players and new targets in organ fibrosis

  2023cites this paper
• CircLASP1 silence strengthens the therapeutic effects of MK‐2206 on nasopharyngeal cancer through upregulating miR‐625

  2023cites this paper
• Comprehensive analysis of aberrantly expressed circRNAs, mRNAs and lncRNAs in patients with nasopharyngeal carcinoma

  2023cites this paper
• Analysis of circRNA-miRNA-mRNA Regulatory Network in Peripheral Blood of Radiation Workers

  2022cites this paper
• CircRNAs in Malignant Tumor Radiation: The New Frontier as Radiotherapy Biomarkers

  2022cites this paper
• Identification of the regulatory role of the circ_0004788/miR‐515‐5p/FGF2 network in nasopharyngeal carcinoma development

  2022cites this paper
• CircRNAs in Tumor Radioresistance

  2022cites this paper
• The Potent Regulatory Role of Circular RNAs in Breast Cancer Development, Diagnosis and Treatment: An Update

  2022cites this paper
• Insight into LncRNA- and CircRNA-Mediated CeRNAs: Regulatory Network and Implications in Nasopharyngeal Carcinoma—A Narrative Literature Review

  2022cites this paper
• Mechanism and Function of Circular RNA in Regulating Solid Tumor Radiosensitivity

  2022cites this paper
• The interplay of cytokine signaling and non-coding RNAs in head and neck squamous cell carcinoma pathobiology

  2022influential citation
• Diagnostic and prognostic value of circRNAs expression in head and neck squamous cell carcinoma: A meta‐analysis

  2022cites this paper
• Knockdown of Circ_0003506 Impedes Radioresistance, Cell Growth, Migration and Invasion in Gastric Cancer

  2022cites this paper
• The emerging roles of circular RNAs in vessel co-option and vasculogenic mimicry: clinical insights for anti-angiogenic therapy in cancers

  2021cites this paper
• Targeting the signaling in Epstein–Barr virus-associated diseases: mechanism, regulation, and clinical study

  2021cites this paper
• Circular RNA hsa_circ_0000554 promotes progression and elevates radioresistance through the miR-485-5p/fermitin family members 1 axis in esophageal cancer.

  2021cites this paper
• Hsa_circ_0000199 facilitates chemo-tolerance of triple-negative breast cancer by interfering with miR-206/613-led PI3K/Akt/mTOR signaling

  2021cites this paper
• CircNRIP1 Modulates the miR-515-5p/IL-25 Axis to Control 5-Fu and Cisplatin Resistance in Nasopharyngeal Carcinoma

  2021cites this paper
• Role of Non-coding RNAs on the Radiotherapy Sensitivity and Resistance of Head and Neck Cancer: From Basic Research to Clinical Application

  2021cites this paper
• Knockdown of circ_NEK6 Decreased 131I Resistance of Differentiated Thyroid Carcinoma via Regulating miR-370-3p/MYH9 Axis

  2021cites this paper
• circ-PSD3 promoted proliferation and invasion of papillary thyroid cancer cells via regulating the miR-7-5p/METTL7B axis

  2021cites this paper
• Regulation of cell signaling pathways by circular RNAs and microRNAs in different cancers: Spotlight on Wnt/β-catenin, JAK/STAT, TGF/SMAD, SHH/GLI, NOTCH and Hippo pathways.

  2021cites this paper
• Circ_0055625 knockdown inhibits tumorigenesis and improves radiosensitivity by regulating miR-338-3p/MSI1 axis in colon cancer

  2021cites this paper
• CircRNA circTRAF3 promotes nasopharyngeal carcinoma metastasis through targeting miR-203a-3p/AKT3 axis.

  2021cites this paper
• Research Progress of circRNAs in Head and Neck Cancers

  2021cites this paper
• Research progress on three different types of noncoding RNAs related to ionizing radiation

  2021cites this paper
• Hsa_circ_0014879 regulates the radiosensitivity of esophageal squamous cell carcinoma through miR-519-3p/CDC25A axis

  2021cites this paper
• Knockdown of circ_0008344 contributes to radiosensitization in glioma via miR-433-3p/RNF2 axis

  2021cites this paper
• DDDT_A_292180 323..330

  2021cites this paper
• Cross-link between ferroptosis and nasopharyngeal carcinoma: New approach to radiotherapy sensitization

  2021cites this paper
• Circular RNAs in prostate cancer: Biogenesis,biological functions, and clinical significance

  2021cites this paper
• Competitive Endogenous RNA Landscape in Epstein-Barr Virus Associated Nasopharyngeal Carcinoma

  2021cites this paper
• The dual role of microRNA-9 in gastrointestinal cancers: oncomiR or tumor suppressor?

  2021cites this paper
• Circ-DONSON Knockdown Inhibits Cell Proliferation and Radioresistance of Breast Cancer Cells via Regulating SOX4

  2021cites this paper
• Circular RNAs: Functions and mechanisms in nasopharyngeal carcinoma

  2021cites this paper
• Knockdown of circ_0008344 contributes to radiosensitization in glioma via miR-433-3p/RNF2 axis

  2021cites this paper
• Caprin1 targeted by circular circ_0000885 in the tumor progression of osteosarcoma.

  2020cites this paper
• The Potential of Circular RNAs as Cancer Biomarkers

  2020cites this paper
• Functions and mechanisms of circular RNAs in cancer radiotherapy and chemotherapy resistance

  2020cites this paper
• CircPSMC3 inhibits cell proliferation and induces cell apoptosis in nasopharyngeal carcinoma by downregulating ROCK1.

  2020cites this paper
• Heterozygous p53-R280T Mutation Enhances the Oncogenicity of NPC Cells Through Activating PI3K-Akt Signaling Pathway

  2020cites this paper
• The Research Progression and Clinical Significance of Circular RNAs in Head and Neck Cancers

  2020cites this paper
• CircCTDP1 promotes nasopharyngeal carcinoma progression via a microRNA-320b/HOXA10/TGFβ2 pathway

  2020cites this paper
• Diagnostic value of exosomal circMYC in radioresistant nasopharyngeal carcinoma

  2020cites this paper
• CircRNA circ-0038718 promotes hepatocellular carcinoma progression through sponging miR-139-3p.

  2020cites this paper
• The role of circular RNAs in therapy resistance of patients with solid tumors.

  2020cites this paper
• Circ_0086720 knockdown strengthens the radiosensitivity of non-small cell lung cancer via mediating the miR-375/SPIN1 axis.

  2020cites this paper
• LINC00665/miR-9-5p/ATF1 is a novel axis involved in the progression of colorectal cancer

  2020cites this paper
• Knockdown of Circ_CCNB2 Sensitizes Prostate Cancer to Radiation Through Repressing Autophagy by the miR-30b-5p/KIF18A Axis

  2020cites this paper
• Implication of hsa_circ_0028007 in reinforcing migration, invasion, and chemo‐tolerance of nasopharyngeal carcinoma cells

  2020cites this paper
• Circle RNA circABCB10 Modulates PFN2 to Promote Breast Cancer Progression, as Well as Aggravate Radioresistance Through Facilitating Glycolytic Metabolism Via miR-223-3p

  2020cites this paper
• CircRNAs: potency of protein translation and feasibility of novel biomarkers and therapeutic targets for head and neck cancers.

  2020influential citation
• Circular RNA circ_0008450 upregulates CXCL9 expression by targeting miR-577 to regulate cell proliferation and invasion in nasopharyngeal carcinoma.

  2019cites this paper
• Circular RNAs and gastrointestinal cancers: Epigenetic regulators with a prognostic and therapeutic role.

  2019cites this paper
• Circular RNA_LARP4 inhibits cell proliferation and invasion of nasopharyngeal carcinoma by repressing ROCK1.

  2019cites this paper
• Star Circular RNAs In Human Cancer: Progress And Perspectives

  2019cites this paper
• Star Circular RNAs In Human Cancer: Progress And Perspectives

  2019cites this paper
• CMAR_A_218967 8023..8031

  2019cites this paper
• Knockdown of EBV-encoded circRNA circRPMS1 suppresses nasopharyngeal carcinoma cell proliferation and metastasis through sponging multiple miRNAs

  2019cites this paper
• Radio-Susceptibility of Nasopharyngeal Carcinoma: Focus on Epstein-Barr virus, MicroRNAs, Long non-coding RNAs and Circular RNAs.

  2019cites this paper