TNF‐α Upregulates IKKε Expression via the Lin28B/let‐7a Pathway to Induce Catecholamine Resistance in Adipocytes

Overexpression of inhibitor of nuclear factor kappa‐B kinase subunit epsilon (IKKε) contributes to blunted catecholamine‐induced lipolysis. Tumor necrosis factor α (TNF‐α) upregulates adipose IKKε expression to inhibit stimulated lipolysis, which can be reversed by IKKε inhibitors. This study investigated adipose IKKε expression in children with and without obesity and potential involvement of the Lin28B/let‐7a axis in posttranscriptional regulation of TNF‐α‐stimulated IKKε in adipocytes.

• Publication year

  2019

• Venue

  Obesity

• Publication date

  2019-05-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1002/oby.22434PMID 30933434
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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