Restoration of hepatic glycogen deposition reduces hyperglycaemia, hyperphagia and gluconeogenic enzymes in a streptozotocin-induced model of diabetes in rats

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Diabetologia

• Publication date

  2011-08-03

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s00125-011-2238-xPMID 21811873
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Hepatic Glycogen Supercompensation Activates AMP-Activated Protein Kinase, Impairs Insulin Signaling, and Reduces Glycogen Deposition in the Liver

  2011cited by this paper
• Hepatic Overexpression of a Constitutively Active Form of Liver Glycogen Synthase Improves Glucose Homeostasis*

  2010cited by this paper
• Impaired Glucose Tolerance and Predisposition to the Fasted State in Liver Glycogen Synthase Knock-out Mice*

  2010cited by this paper
• Bulletin of the New England Medical Center, Volume XIV, April-June 1952: The glucostatic theory of regulation of food intake and the problem of obesity (a review)

  2009cited by this paper
• Control of Liver Glycogen Synthase Activity and Intracellular Distribution by Phosphorylation*

  2009cited by this paper
• The Experimental Type 2 Diabetes Therapy Glycogen Phosphorylase Inhibition Can Impair Aerobic Muscle Function During Prolonged Contraction

  2006cited by this paper
• Hepatic Expression of a Targeting Subunit of Protein Phosphatase-1 in Streptozotocin-diabetic Rats Reverses Hyperglycemia and Hyperphagia Despite Depressed Glucokinase Expression*

  2003cited by this paper
• Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo.

  2003cited by this paper
• Glucose 6-Phosphate Produced by Gluconeogenesis and by Glucokinase Is Equally Effective in Activating Hepatic Glycogen Synthase*

  2003cited by this paper
• Liver Glycogen Synthase but Not the Muscle Isoform Differentiates between Glucose 6-Phosphate Produced by Glucokinase or Hexokinase*

  2002cited by this paper
• Reversal of Diet-induced Glucose Intolerance by Hepatic Expression of a Variant Glycogen-targeting Subunit of Protein Phosphatase-1*

  2002cited by this paper
• Effects of a novel glycogen synthase kinase-3 inhibitor on insulin-stimulated glucose metabolism in Zucker diabetic fatty (fa/fa) rats.

  2002cited by this paper
• Intracellular distribution of glycogen synthase and glycogen in primary cultured rat hepatocytes.

  2001cited by this paper
• Inhibition of GSK-3 selectively reduces glucose-6-phosphatase and phosphatase and phosphoenolypyruvate carboxykinase gene expression.

  2001cited by this paper
• The level of the glycogen targetting regulatory subunit R5 of protein phosphatase 1 is decreased in the livers of insulin-dependent diabetic rats and starved rats.

  2001cited by this paper
• Inhibition of GSK-3 Selectively Reduces Glucose-6-Phosphatase and Phosphoenolpyruvate Carboxykinase Gene Expression

  2001cited by this paper
• Shared control of hepatic glycogen synthesis by glycogen synthase and glucokinase.

  2000cited by this paper
• Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription.

  2000cited by this paper
• Identification of Two Essential Glutamic Acid Residues in Glycogen Synthase*

  2000cited by this paper
• Low plasma leptin levels contribute to diabetic hyperphagia in rats.

  1999cited by this paper
• Metabolic impact of glucokinase overexpression in liver: lowering of blood glucose in fed rats is accompanied by hyperlipidemia.

  1999cited by this paper
• Glucokinase regulatory protein is essential for the proper subcellular localisation of liver glucokinase

  1999cited by this paper
• Banting Lecture 1997. Control of glucose uptake and release by the liver in vivo.

  1999cited by this paper
• Novel Aspects of the Regulation of Glycogen Storage

  1998cited by this paper
• Loss of the hepatic glycogen-binding subunit (GL) of protein phosphatase 1 underlies deficient glycogen synthesis in insulin-dependent diabetic rats and in adrenalectomized starved rats.

  1998cited by this paper
• Perturbation of Fuel Homeostasis Caused by Overexpression of the Glucose-6-phosphatase Catalytic Subunit in Liver of Normal Rats*

  1998cited by this paper
• Carbohydrate balance and body-weight regulation

  1996cited by this paper
• Impaired hepatic glycogen synthesis in glucokinase-deficient (MODY-2) subjects.

  1996cited by this paper
• The Groove between the α- and β-Subunits of Hormones with Lutropin (LH) Activity Appears to Contact the LH Receptor, and Its Conformation Is Changed during Hormone Binding (*)

  1995cited by this paper
• The Effects of Streptozotocin-induced Diabetes and Insulin Supplementation on Expression of the Glycogen Phosphorylase Gene in Rat Liver (*)

  1995cited by this paper
• 13C-nuclear magnetic resonance spectroscopy studies of hepatic glucose metabolism in normal subjects and subjects with insulin-dependent diabetes mellitus.

  1994cited by this paper
• Use of recombinant adenovirus for metabolic engineering of mammalian cells.

  1994cited by this paper
• Adenovirus-mediated transfer of low density lipoprotein receptor gene acutely accelerates cholesterol clearance in normal mice.

  1993cited by this paper
• Mammalian glucokinase and its gene.

  1993cited by this paper
• Increased rate of gluconeogenesis in type II diabetes mellitus. A 13C nuclear magnetic resonance study.

  1992cited by this paper
• Evidence that GLUT-2 mRNA and protein concentrations are decreased by hyperinsulinaemia and increased by hyperglycaemia in liver of diabetic rats.

  1992cited by this paper
• The genes of hepatic glucose metabolism.

  1990influential reference
• Effect of hepatic portal glucose concentration on food intake and metabolism.

  1989cited by this paper
• Hepatic control of feeding: effect of glucose, fructose, and mannitol infusion.

  1988cited by this paper
• Insulin control of rat hepatocyte glycogen synthase and phosphorylase in the absence of glucose

  1977cited by this paper
• A rapid method for the determination of glycogen content and radioactivity in small quantities of tissue or isolated hepatocytes.

  1976cited by this paper
• A rapid filter paper assay for UDPglucose-glycogen glucosyltransferase, including an improved biosynthesis of UDP-14C-glucose.

  1968influential reference
• Participation of Hepatic Glucoreceptors in the Control of Intake of Food

  1963cited by this paper
• GLUCOSTATIC MECHANISM OF REGULATION OF FOOD INTAKE

  1953cited by this paper

• Sinapine Modulates Glycogen and Lipid Synthesis via IRS1–PI3K–AKT–GSK3β–GS Pathway in Insulin‐Resistant Models

  2026cites this paper
• Decoding the Triterpenoid Gymnemic Acid Biosynthetic Pathway in Gymnema Sylvestre

  2025cites this paper
• Glucose and Insulin Differently Regulate Gluconeogenic and Ureagenic Gene Expression.

  2025cites this paper
• miR-141/200c contributes to ethanol-mediated hepatic glycogen metabolism

  2024cites this paper
• Garcinia Biflavonoid 1 from Garcinia kola Ameliorates Glycolipid Metabolism Disorder in Type 2 Diabetic db/db Mice

  2024cites this paper
• Glycogenin is dispensable for normal liver glycogen metabolism and body glucose homeostasis.

  2024cites this paper
• Active Glycogen Synthase in the Liver Prevents High-Fat Diet-Induced Glucose Intolerance, Decreases Food Intake, and Lowers Body Weight

  2023influential citation
• Dendropanoxide Alleviates Thioacetamide-induced Hepatic Fibrosis via Inhibition of ROS Production and Inflammation in BALB/C Mice

  2023cites this paper
• The hepatoprotective effects of n3-polyunsaturated fatty acids against non-alcoholic fatty liver disease in diabetic rats through the FOXO1/PPARα/GABARAPL1 signalling pathway.

  2022cites this paper
• Oat phenolic compounds regulate metabolic syndrome in high fat diet-fed mice via gut microbiota

  2022cites this paper
• Hepato-protective effects of thymoquinone and beta-aminoisobutyric acid in streptozocin induced diabetic rats

  2021cites this paper
• Therapeutic Potentials of Colocasia affinis Leaf Extract for the Alleviation of Streptozotocin-Induced Diabetes and Diabetic Complications: In vivo and in silico-Based Studies

  2021cites this paper
• Increasing hepatic glycogen moderates the diabetic phenotype in insulin-deficient Akita mice

  2021cites this paper
• Maintenance of liver glycogen during long‐term fasting preserves energy state in mice

  2020cites this paper
• Effect of 1-Deoxynojirimycin Isolated from Mulberry Leaves on Glucose Metabolism and Gut Microbiota in a Streptozotocin-Induced Diabetic Mouse Model.

  2019cites this paper
• Combination of mulberry leaf and oat bran possessed greater hypoglycemic effect on diabetic mice than mulberry leaf or oat bran alone

  2019cites this paper
• Effect of methamphetamine on the fasting blood glucose in methamphetamine abusers

  2018cites this paper
• Melatonin attenuates smoking‐induced hyperglycemia via preserving insulin secretion and hepatic glycogen synthesis in rats

  2018cites this paper
• Rice Bran Oil Improves Insulin Resistance by Affecting the Expression of Antioxidants and Lipid-Regulatory Genes.

  2018cites this paper
• Panax ginseng improves glucose metabolism in streptozotocin-induced diabetic rats through 5′ adenosine monophosphate kinase up-regulation

  2018cites this paper
• Lack of liver glycogen causes hepatic insulin resistance and steatosis in mice

  2017cites this paper
• Hypoglycemic effect and mechanism of a pectic polysaccharide with hexenuronic acid from the fruits of Ficus pumila L. in C57BL/KsJ db/db mice.

  2017cites this paper
• Effects of hepatic glycogen on food intake and glucose homeostasis are mediated by the vagus nerve in mice

  2017cites this paper
• Hepatic Overexpression of CD36 Improves Glycogen Homeostasis and Attenuates High-Fat Diet-Induced Hepatic Steatosis and Insulin Resistance

  2016cites this paper
• High-fructose and high-fat diet-induced disorders in rats: impact on diabetes risk, hepatic and vascular complications

  2016cites this paper
• 1-Deoxynojirimycin Alleviates Liver Injury and Improves Hepatic Glucose Metabolism in db/db Mice

  2016cites this paper
• A novel formula Sang-Tong-Jian improves glycometabolism and ameliorates insulin resistance by activating PI3K/AKT pathway in type 2 diabetic KKAy mice.

  2016cites this paper
• The effects of caffeic acid phenethyl ester on streptozotocin-induced diabetic liver injury.

  2016cites this paper
• Anti-diabetes effect of chronic intermittent hypobaric hypoxia through improving liver insulin resistance in diabetic rats.

  2016cites this paper
• Over-expression of muscle glycogen synthase in human diabetic nephropathy

  2015cites this paper
• Extracts from Salvia-Nelumbinis naturalis alleviate hepatosteatosis via improving hepatic insulin sensitivity

  2014cites this paper
• Liver Glycogen Reduces Food Intake and Attenuates Obesity in a High-Fat Diet–Fed Mouse Model

  2014influential citation
• Dysfunctional Muscle and Liver Glycogen Metabolism in mdx Dystrophic Mice

  2014cites this paper
• Pathway-selective Insulin Resistance and Metabolic Disease: The Importance of Nutrient Flux*

  2014cites this paper
• Liraglutide ameliorates glycometabolism and insulin resistance through the upregulation of GLUT4 in diabetic KKAy mice.

  2013cites this paper
• Sodium tungstate activates glycogen synthesis through a non‐canonical mechanism involving G‐proteins

  2013cites this paper
• Restoration of direct pathway glycogen synthesis flux in the STZ-diabetes rat model by insulin administration.

  2012cites this paper