Dominant-negative transcription factor AP-2 augments SB-2 melanoma tumor growth in vivo

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Oncogene

• Publication date

  2001-06-07

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/sj.onc.1204450PMID 11423987
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Role of AP-2 in Tumor Growth and Metastasis of Human Melanoma

  2004cited by this paper
• Inhibition of tumor growth and metastasis of human melanoma by intracellular anti-ATF-1 single chain Fv fragment

  2000cited by this paper
• Level of interleukin-8 expression by metastatic human melanoma cells directly correlates with constitutive NF-kappaB activity.

  2000cited by this paper
• Regulation of tumor growth and metastasis of human melanoma by the CREB transcription factor family

  2000cited by this paper
• Failure in post-transcriptional processing is a possible inactivation mechanism of AP-2 α in cutaneous melanoma

  2000cited by this paper
• Nuclear factor-kappaB activity correlates with growth, angiogenesis, and metastasis of human melanoma cells in nude mice.

  2000cited by this paper
• Nuclear Factor-κB Activity Correlates with Growth, Angiogenesis, and Metastasis of Human Melanoma Cells in Nude Mice

  2000cited by this paper
• Relative expression of type IV collagenase, E-cadherin, and vascular endothelial growth factor/vascular permeability factor in prostatectomy specimens distinguishes organ-confined from pathologically advanced prostate cancers.

  2000cited by this paper
• Matrix metalloproteinases in human melanoma cell lines and xenografts: increased expression of activated matrix metalloproteinase-2 (MMP-2) correlates with melanoma progression

  1999cited by this paper
• Matrix metalloproteinase‐2 (MMP‐2) immunoreactive protein—a new prognostic marker in uveal melanoma?

  1999cited by this paper
• Keratin 10 gene expression during differentiation of mouse epidermis requires transcription factors C/EBP and AP-2.

  1999cited by this paper
• PolyADP-ribose polymerase is a coactivator for AP-2-mediated transcriptional activation.

  1999cited by this paper
• Role of microphthalmia transcription factor in regulation of melanocyte differentiation marker TRP-1.

  1999cited by this paper
• p21/WAF1 expression in human colorectal carcinoma: association with p53, transcription factor AP-2 and prognosis

  1999cited by this paper
• Microphthalmia transcription factor. A sensitive and specific melanocyte marker for MelanomaDiagnosis.

  1999cited by this paper
• The Transcription Factors Sp1, Sp3, and AP-2 Are Required for Constitutive Matrix Metalloproteinase-2 Gene Expression in Astroglioma Cells*

  1999cited by this paper
• Prognostic value of MMP‐2 immunoreactive protein (72 kD type IV collagenase) in primary skin melanoma

  1998cited by this paper
• Downregulation of transcription factor AP-2 predicts poor survival in stage I cutaneous malignant melanoma.

  1998cited by this paper
• In vivo and in vitro generation of a new altered HLA phenotype in melanoma‐tumour‐cell variants expressing a single HLA‐class‐I allele

  1998cited by this paper
• Loss of AP‐2 results in downregulation of c‐KIT and enhancement of melanoma tumorigenicity and metastasis

  1998cited by this paper
• Loss of AP-2 Results in Up-regulation ofMCAM/MUC18 and an Increase in Tumor Growth and Metastasis of Human Melanoma Cells*

  1998cited by this paper
• CREB and Its Associated Proteins Act as Survival Factors for Human Melanoma Cells*

  1998cited by this paper
• Convergence of MAP kinase pathways on the ternary complex factor Sap‐1a

  1997cited by this paper
• Expression of MCAM/MUC18 by human melanoma cells leads to increased tumor growth and metastasis.

  1997cited by this paper
• AP2 inhibits cancer cell growth and activates p21WAF1/CIP1 expression

  1997cited by this paper
• Dominant-negative CREB inhibits tumor growth and metastasis of human melanoma cells

  1997cited by this paper
• Expression of interleukin-8 by human melanoma cells up-regulates MMP-2 activity and increases tumor growth and metastasis.

  1997cited by this paper
• Molecular mechanisms of melanoma metastasis

  1997cited by this paper
• Genomic Cloning and Characterization of the Human Thrombin Receptor Gene

  1996cited by this paper
• Repression of a matrix metalloprotease gene by E1A correlates with its ability to bind to cell type-specific transcription factor AP-2.

  1996cited by this paper
• Activation of transcription factor AP-2 mediates UVA radiation- and singlet oxygen-induced expression of the human intercellular adhesion molecule 1 gene.

  1996cited by this paper
• Transcription factor AP-2 essential for cranial closure and craniofacial development

  1996cited by this paper
• Neural tube, skeletal and body wall defects in mice lacking transcription factor AP-2

  1996cited by this paper
• Wavelength-specific induction of immediate early genes by ultraviolet radiation.

  1996cited by this paper
• Transcriptional activation by Myc is under negative control by the transcription factor AP‐2.

  1995cited by this paper
• The developmentally regulated transcription factor AP-2 is involved in c-erbB-2 overexpression in human mammary carcinoma.

  1995cited by this paper
• Transcription Factor AP-2 Regulates Human Insulin-like Growth Factor Binding Protein-5 Gene Expression (*)

  1995cited by this paper
• Loss of heterozygosity in sporadic primary cutaneous melanoma

  1995cited by this paper
• Matrix metalloproteinases in blood vessel development in human fetal skin and in cutaneous tumors.

  1995cited by this paper
• Abnormalities in the CDKN2 (p16INK4/MTS-1) gene in human melanoma cells: relevance to tumor growth and metastasis.

  1995cited by this paper
• Identification of p90RSK as the probable CREB-Ser133 kinase in human melanocytes.

  1995cited by this paper
• Microdissection based cloning of a translocation breakpoint in a human malignant melanoma.

  1995cited by this paper
• Ultraviolet B irradiation promotes tumorigenic and metastatic properties in primary cutaneous melanoma via induction of interleukin 8.

  1995cited by this paper
• The genomic structure of the human AP-2 transcription factor.

  1994cited by this paper
• Expression and transcriptional activity of Ap‐1, CRE, and URE binding proteins in B16 mouse melanoma subclones

  1994cited by this paper
• Isolation and functional characterization of the A32 melanoma-associated antigen.

  1994cited by this paper
• N-ras oncogene causes AP-2 transcriptional self-interference, which leads to transformation.

  1994influential reference
• An alternatively spliced mRNA from the AP-2 gene encodes a negative regulator of transcriptional activation by AP-2

  1993influential reference
• KIT ligand (mast cell growth factor) inhibits the growth of KIT-expressing melanoma cells.

  1993cited by this paper
• Direct correlation between MUC18 expression and metastatic potential of human melanoma cells.

  1993cited by this paper
• Loss of c-kit expression in cultured melanoma cells.

  1992cited by this paper
• The Putative Melanoma Tumor‐Suppressor Gene on Human Chromosome 6q

  1992cited by this paper
• Transcription factor AP-2 is expressed in neural crest cell lineages during mouse embryogenesis.

  1991cited by this paper
• Analysis of the DNA-binding and activation properties of the human transcription factor AP-2.

  1991cited by this paper
• Cancer metastasis.

  1991influential reference
• Transcription factor AP2 and its role in epidermal-specific gene expression.

  1991cited by this paper
• Localization of the gene for the DNA-binding protein AP-2 to human chromosome 6p22.3-pter.

  1991cited by this paper
• Characterization of a dimerization motif in AP-2 and its function in heterologous DNA-binding proteins.

  1991cited by this paper
• Metalloproteinases and cancer invasion.

  1990cited by this paper
• Tumor interactions with the vasculature: angiogenesis and tumor metastasis.

  1990cited by this paper
• Positive and negative transcriptional elements of the human type IV collagenase gene

  1990influential reference
• An AP-2 element acts synergistically with the cyclic AMP- and phorbol ester-inducible enhancer of the human proenkephalin gene.

  1989cited by this paper
• Identification of a recurring translocation site involving chromosome 6 in human malignant melanoma.

  1989cited by this paper
• The SV40 TC‐II(kappa B) and the related H‐2Kb enhansons exhibit different cell type specific and inducible proto‐enhancer activities, but the SV40 core sequence and the AP‐2 binding site have no enhanson properties.

  1989cited by this paper
• Regulation of transcription factor AP-2 by the morphogen retinoic acid and by second messengers.

  1989cited by this paper
• MUC18, a marker of tumor progression in human melanoma, shows sequence similarity to the neural cell adhesion molecules of the immunoglobulin superfamily.

  1989cited by this paper
• Correlation of growth capacity of human tumor cells in hard agarose with their in vivo proliferative capacity at specific metastatic sites.

  1989cited by this paper
• Cloning and expression of AP-2, a cell-type-specific transcription factor that activates inducible enhancer elements.

  1988cited by this paper
• Effect of ultraviolet-B radiation on the in vivo growth of murine melanoma cells.

  1988cited by this paper
• Transcription factor AP-2 mediates induction by two different signal-transduction pathways: protein kinase C and cAMP.

  1987cited by this paper
• Positive and negative regulation of transcription in vitro: enhancer-binding protein AP-2 is inhibited by SV40 T antigen.

  1987cited by this paper
• Activation of transcription by two factors that bind promoter and enhancer sequences of the human metallothionein gene and SV40

  1987cited by this paper
• Tumor invasion and metastases--role of the extracellular matrix: Rhoads Memorial Award lecture.

  1986cited by this paper
• Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family.

  1985influential reference
• Upstream promoter element of the human metallothionein-IIA gene can act like an enhancer element.

  1985cited by this paper
• Involvement of chromosome 6 in rearrangements in human malignant melanoma cell lines.

  1983cited by this paper
• Epidemiology of pre‐invasive and invasive malignant melanoma in Western Australia

  1980cited by this paper
• Metastatic potential correlates with enzymatic degradation of basement membrane collagen

  1980cited by this paper

• Transcription factor activating enhancer-binding protein 2ε (AP2ε) modulates phenotypic plasticity and progression of malignant melanoma

  2024cites this paper
• Crucial role of the transcription factors family activator protein 2 in cancer: current clue and views

  2023cites this paper
• Identification and Characterization of Alternatively Spliced Transcript Isoforms of IRX4 in Prostate Cancer

  2021cites this paper
• TFAP-2: A Special Regulator with Bidirectional Effect in Human Cancer

  2021cites this paper
• Transcription Factors in Cancer: When Alternative Splicing Determines Opposite Cell Fates

  2020cites this paper
• The biological characteristics of transcription factors AP-2α and AP-2γ and their importance in various types of cancers

  2019cites this paper
• The nitrobenzoxadiazole derivative MC3181 blocks melanoma invasion and metastasis

  2017cites this paper
• SOCS1 favors the epithelial-mesenchymal transition in melanoma, promotes tumor progression and prevents antitumor immunity by PD-L1 expression

  2017cites this paper
• miRNAs in melanoma: a defined role in tumor progression and metastasis

  2016cites this paper
• AP-2β Is a Downstream Effector of PITX2 Required to Specify Endothelium and Establish Angiogenic Privilege During Corneal Development

  2016cites this paper
• Bimetallic Pt/Pd encapsulated mesoporous-hollow CeO2 nanospheres for signal amplification toward electrochemical peptide-based biosensing for matrix metalloproteinase 2

  2016cites this paper
• A network model for angiogenesis in ovarian cancer

  2015cites this paper
• NFAT1 CONTRIBUTES TO MELANOMA TUMOR GROWTH AND METASTASIS BY REGULATING IL-8 AND MMP-3

  2015cites this paper
• Why is melanoma so metastatic?

  2014cites this paper
• miR-638 promotes melanoma metastasis and protects melanoma cells from apoptosis and autophagy

  2014cites this paper
• Ocena ekspresji mRNA dla kolagenów typu I, III i IV oraz metaloproteinaz MMP-2 i MMP-9 w guzkowym raku podstawnokomórkowym i odmianie naciekającej

  2014influential citation
• Signal enhancement of silicon nanowire-based biosensor for detection of matrix metalloproteinase-2 using DNA-Au nanoparticle complexes.

  2013cites this paper
• AP-2α suppresses invasion in BeWo cells by repression of matrix metalloproteinase-2 and -9 and up-regulation of E-cadherin

  2013cites this paper
• Galectin-3 Enhances the Malignant Melanoma Phenotype by Regulating Autotaxin

  2013cites this paper
• Synergistic silencing by promoter methylation and reduced AP-2α transactivation of the proapoptotic HRK gene confers apoptosis resistance and enhanced tumor growth.

  2013cites this paper
• The transcription factor activating enhancer‐binding protein epsilon (AP–2ε) regulates the core promoter of type II collagen (COL2A1)

  2013cites this paper
• Driving transcriptional regulators in melanoma metastasis

  2012cites this paper
• Transcription factor activator protein 2 in development and disease of the neural crest

  2012cites this paper
• microRNA‐214 contributes to melanoma tumour progression through suppression of TFAP2C

  2011cites this paper
• The Emerging Role of the Thrombin Receptor (PAR-1) in Melanoma Metastasis - a Possible Therapeutic Target

  2011cites this paper
• AP-2α expression and cell apoptosis of the lung tissue of rats with COPD and ECV304 cells stimulated by cigarette smoke extract

  2011cites this paper
• CREB Inhibits AP-2α Expression to Regulate the Malignant Phenotype of Melanoma

  2010cites this paper
• Jeffe rson Digital Commons

  2010cites this paper
• Regulation of breast tumour cell survival by AP-2 transcription factors

  2010cites this paper
• Biological rationale for the use of DNA methyltransferase inhibitors as new strategy for modulation of tumor response to chemotherapy and radiation

  2010cites this paper
• Tumor suppressor HLJ1 binds and functionally alters nucleophosmin via activating enhancer binding protein 2alpha complex formation.

  2010cites this paper
• Tumor and Stem Cell Biology Cancer Research Tumor Suppressor HLJ 1 Binds and Functionally Alters Nucleophosmin via Activating Enhancer Binding Protein 2 α Complex Formation

  2010cites this paper
• Transcriptional regulation in melanoma.

  2009cites this paper
• Silencing cAMP-response Element-binding Protein (CREB) Identifies CYR61 as a Tumor Suppressor Gene in Melanoma*

  2009cites this paper
• Activator protein-2 impairs the invasion of a human extravillous trophoblast cell line.

  2009cites this paper
• n-Butylidenephthalide induced apoptosis in the A549 human lung adenocarcinoma cell line by coupled down-regulation of AP-2α and telomerase activity

  2009cites this paper
• The AP-2alpha transcription factor is required for the ganglioside GM3-stimulated transcriptional regulation of a PTEN gene.

  2008cites this paper
• Targeting melanoma growth and metastasis with systemic delivery of liposome-incorporated protease-activated receptor-1 small interfering RNA.

  2008cites this paper
• Transcriptional control of the melanoma malignant phenotype

  2008cites this paper
• Quantitative analysis of melanocytic tissue array reveals inverse correlation between activator protein-2alpha and protease-activated receptor-1 expression during melanoma progression.

  2007cites this paper
• Clinical implications of HER‐2/neu overexpression and proteolytic activity imbalance in breast cancer

  2007cites this paper
• Activator protein‐2 in carcinogenesis with a special reference to breast cancer—A mini review

  2007cites this paper
• Loss of AP-2alpha results in deregulation of E-cadherin and MMP-9 and an increase in tumorigenicity of colon cancer cells in vivo.

  2007cites this paper
• Transcription factor AP-2alpha represses both the mucin MUC4 expression and pancreatic cancer cell proliferation.

  2007cites this paper
• Rad51 overexpression contributes to chemoresistance in human soft tissue sarcoma cells: a role for p53/activator protein 2 transcriptional regulation

  2007cites this paper
• ACTIBIND, a T2 RNase, competes with angiogenin and inhibits human melanoma growth, angiogenesis, and metastasis.

  2007cites this paper
• Regulation of KiSS-1 Metastasis Suppressor Gene Expression in Breast Cancer Cells by Direct Interaction of Transcription Factors Activator Protein-2α and Specificity Protein-1*

  2006cites this paper
• Jak3- and JNK-dependent vascular endothelial growth factor expression in cutaneous T-cell lymphoma

  2006cites this paper
• AP2alpha alters the transcriptional activity and stability of p53.

  2006cites this paper
• AP2α alters the transcriptional activity and stability of p53

  2006cites this paper
• Apoptosis Induction by Activator Protein 2α Involves Transcriptional Repression of Bcl-2*

  2006cites this paper
• Transcriptional Regulation of ULBP1, a Human Ligand of the NKG2D Receptor*

  2006cites this paper
• Role and Regulation of PAR-1 in Melanoma Progression

  2006cites this paper
• Characteristics of the Metastatic Phenotype

  2006cites this paper
• Activator protein 2alpha status determines the chemosensitivity of cancer cells: implications in cancer chemotherapy.

  2005cites this paper
• Loss of the AP-2alpha transcription factor is associated with the grade of human gliomas.

  2005cites this paper
• Automated quantitative analysis of activator protein-2alpha subcellular expression in melanoma tissue microarrays correlates with survival prediction.

  2005cites this paper
• Somasundaram of Cancer Cells : Implications in Cancer Chemotherapy Status Determines the Chemosensitivity α Activator Protein 2

  2005cites this paper
• Temporally regulated neural crest transcription factors distinguish neuroectodermal tumors of varying malignancy and differentiation.

  2005cites this paper
• Regulation of gene expression in melanoma: New approaches for treatment

  2005cites this paper
• Activator protein 2alpha inhibits tumorigenicity and represses vascular endothelial growth factor transcription in prostate cancer cells.

  2004cites this paper
• Construction and expression of intracellular anti-ATF-1 single chain Fv fragment: a modality to inhibit melanoma tumor growth and metastasis.

  2004cites this paper
• Molecular regulation of angiogenesis and tumorigenesis by signal transduction pathways: evidence of predictable and reproducible patterns of synergy in diverse neoplasms.

  2004cites this paper
• Transcription factor AP-2α triggers apoptosis in cardiac myocytes

  2004cites this paper
• Activator protein-2gamma (AP-2gamma) expression is specifically induced by oestrogens through binding of the oestrogen receptor to a canonical element within the 5'-untranslated region.

  2004cites this paper
• Transcription factor AP-2alpha triggers apoptosis in cardiac myocytes.

  2004cites this paper
• Expression of Matrix Metalloproteinase (MMP)-2 and MMP-9 in Breast Cancer with a Special Reference to Activator Protein-2, HER2, and Prognosis

  2004cites this paper
• Transcriptional regulation of metastasis-related genes in human melanoma

  2004cites this paper
• Suppression of invasion and peritoneal carcinomatosis of ovarian cancer cells by overexpression of AP-2α

  2004influential citation
• Activator Protein 2α Inhibits Tumorigenicity and Represses Vascular Endothelial Growth Factor Transcription in Prostate Cancer Cells

  2004cites this paper
• Expression of HER2 and its association with AP-2 in breast cancer.

  2004cites this paper
• Loss of Activator Protein-2α Results in Overexpression of Protease-activated Receptor-1 and Correlates with the Malignant Phenotype of Human Melanoma*

  2003cites this paper
• Role and regulation of the thrombin receptor (PAR-1) in human melanoma

  2003cites this paper
• Fully human anti-interleukin 8 antibody inhibits tumor growth in orthotopic bladder cancer xenografts via down-regulation of matrix metalloproteases and nuclear factor-kappaB.

  2003cites this paper
• Activator protein-2 γ ( AP-2 γ ) expression is specifically induced by oestrogens through binding of the oestrogen receptor to a canonical element within the 5 ′-untranslated region

  2003cites this paper
• p21WAF1 expression in invasive breast cancer and its association with p53, AP-2, cell proliferation, and prognosis

  2003cites this paper
• Cell Cycle Arrest and Apoptosis Induction by Activator Protein 2α (AP-2α) and the Role of p53 and p21WAF1/CIP1 in AP-2α-mediated Growth Inhibition*

  2003cites this paper
• Angiogenesis in cutaneous melanoma: Pathogenesis and clinical implications

  2003cites this paper
• Expression patterns of the transcription factor AP-2alpha during hair follicle morphogenesis and cycling.

  2003cites this paper
• Cell cycle arrest and apoptosis induction by activator protein 2alpha (AP-2alpha) and the role of p53 and p21WAF1/CIP1 in AP-2alpha-mediated growth inhibition.

  2003cites this paper
• Cellular Adhesion Pathways and Metastatic Potential of Human Melanoma

  2002cites this paper
• Fully humanized neutralizing antibodies to interleukin-8 (ABX-IL8) inhibit angiogenesis, tumor growth, and metastasis of human melanoma.

  2002cites this paper
• Reduced nuclear expression of transcription factor AP-2 associates with aggressive breast cancer.

  2002cites this paper
• Tumor Suppressor Activity of AP2α Mediated through a Direct Interaction with p53*

  2002cites this paper
• Gene Regulation in Melanoma Metastasis

  2002cites this paper
• Fully human antibodies to MCAM/MUC18 inhibit tumor growth and metastasis of human melanoma.

  2002cites this paper
• Activator protein 2alpha transcription factor expression is associated with luminal differentiation and is lost in prostate cancer.

  2001cites this paper