The peanut allergy epidemic: allergen molecular characterisation and prospects for specific therapy

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Expert Reviews in Molecular Medicine

• Publication date

  2007-01-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1017/S1462399407000208PMID 17210088
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• IgE cross-reactivity between the major peanut allergen Ara h 2 and tree nut allergens.

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• Oral tolerance and allergic responses to food proteins

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• The promiscuity of immunoglobulin E binding to peanut allergens, as determined by Western blotting, correlates with the severity of clinical symptoms

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• Identification of the basic subunit of Ara h 3 as the major allergen in a group of children allergic to peanuts.

  2005cited by this paper
• Allergenic characteristics of a modified peanut allergen.

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• Mucosal immunity and allergic responses: lack of regulation and/or lack of microbial stimulation?

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• Microarray immunoassay: association of clinical history, in vitro IgE function, and heterogeneity of allergenic peanut epitopes.

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• Peanut, tree nut and seed allergies

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• Prevalence of peanut and tree nut allergy in the United States determined by means of a random digit dial telephone survey: a 5-year follow-up study.

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• The major peanut allergen, Ara h 2, functions as a trypsin inhibitor, and roasting enhances this function.

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• Ana o 2, a Major Cashew (Anacardium occidentale L.) Nut Allergen of the Legumin Family

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• Factors associated with the development of peanut allergy in childhood.

  2003cited by this paper
• Identification and cloning of Jug r 4, a major food allergen from english walnut belonging to the legumin group*

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• IL‐10 and TGF‐β cooperate in the regulatory T cell response to mucosal allergens in normal immunity and specific immunotherapy

  2003cited by this paper
• Effect of anti-IgE therapy in patients with peanut allergy.

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• Renaissance of the Blocking Antibody Concept in Type I Allergy

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• Identification of an 11S globulin as a major hazelnut food allergen in hazelnut-induced systemic reactions.

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• Modification of Peanut Allergen Ara h 3: Effects on IgE Binding and T Cell Stimulation

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• Rising prevalence of allergy to peanut in children: Data from 2 sequential cohorts.

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• Ana o 1, a cashew (Anacardium occidental) allergen of the vicilin seed storage protein family.

  2002cited by this paper
• Identification and Characterisation of the IgE-Binding Proteins 2S Albumin and Conglutin γ in Almond (Prunus dulcis) Seeds

  2002cited by this paper
• Clinical practice. Peanut allergy.

  2002cited by this paper
• Post-transcriptional gene silencing in plants.

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• Oral administration of IL-12 suppresses anaphylactic reactions in a murine model of peanut hypersensitivity.

  2001cited by this paper
• Cross‐reactivity of IgE antibodies to allergens

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• Detection of peanut allergens in breast milk of lactating women.

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• Engineering, Characterization and in vitro Efficacy of the Major Peanut Allergens for Use in Immunotherapy

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• Natural history of peanut allergy

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• Food Allergy Herbal Formula-1 (FAHF-1) blocks peanut-induced anaphylaxis in a murine model.

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• How to make foods safer – genetically modified foods

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• Role of conformational and linear epitopes in the achievement of tolerance in cow's milk allergy

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• Fatalities due to anaphylactic reactions to foods.

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• The natural history of peanut allergy.

  2001cited by this paper
• Structure of the Major Peanut Allergen Ara h 1 May Protect IgE-Binding Epitopes from Degradation1

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• Structural biology of allergens.

  2000cited by this paper
• The effects of roasting on the allergenic properties of peanut proteins.

  2000cited by this paper
• Mechanisms of eosinophil-associated inflammation.

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• Molecular and biochemical classification of plant-derived food allergens.

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• Tertiary Structure and Biophysical Properties of a Major Peanut Allergen, Implications for the Production of a Hypoallergenic Protein

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• Heat-induced Conformational Changes of Ara h 1, a Major Peanut Allergen, Do Not Affect Its Allergenic Properties*

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• Selective Cloning of Peanut Allergens, Including Profilin and 2S Albumins, by Phage Display Technology

  1999cited by this paper
• Sublingual‐swallow immunotherapy (SLIT) in patients with asthma due to house‐dust mites: a double‐blind, placebo‐controlled study

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• Macadamia nut anaphylaxis: demonstration of specific IgE reactivity and partial cross-reactivity with hazelnut.

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• Isolation and Characterization of Allergens

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• Molecular cloning and epitope analysis of the peanut allergen Ara h 3.

  1999cited by this paper
• Identification and cloning of a complementary DNA encoding a vicilin-like proprotein, jug r 2, from english walnut kernel (Juglans regia), a major food allergen.

  1999cited by this paper
• Allergenicity of Maillard reaction products from peanut proteins.

  1999cited by this paper
• Biochemical and Structural Analysis of the IgE Binding Sites on Ara h1, an Abundant and Highly Allergenic Peanut Protein*

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• Clinical Features of Acute Allergic Reactions to Peanut and Tree Nuts in Children

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• Randomised, double blind, crossover challenge study of allergenicity of peanut oils in subjects allergic to peanuts

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• Identification and mutational analysis of the immunodominant IgE binding epitopes of the major peanut allergen Ara h 2.

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• Cross-reactivity between the major allergen from olive pollen and unrelated glycoproteins: evidence of an epitope in the glycan moiety of the allergen.

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• Ubiquitous structures responsible for IgE cross-reactivity between tomato fruit and grass pollen allergens.

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• Reduction of 14–16 kDa allergenic proteins in transgenic rice plants by antisense gene

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• Recombinant peanut allergen Ara h I expression and IgE binding in patients with peanut hypersensitivity.

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• Cold-pressed peanut oils may contain peanut allergen.

  1994cited by this paper
• Inhibition of T cell and antibody responses to house dust mite allergen by inhalation of the dominant T cell epitope in naive and sensitized mice

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• Pistachio nut hypersensitivity: identification of pistachio nut allergens

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• Allergen immunotherapy decreases interleukin 4 production in CD4+ T cells from allergic individuals

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• Identification and characterization of a second major peanut allergen, Ara h II, with use of the sera of patients with atopic dermatitis and positive peanut challenge.

  1992cited by this paper
• Fatal and near-fatal anaphylactic reactions to food in children and adolescents.

  1992cited by this paper
• Treatment of peanut allergy with rush immunotherapy.

  1992cited by this paper
• Identification of a major peanut allergen, Ara h I, in patients with atopic dermatitis and positive peanut challenges.

  1991cited by this paper
• Cross-allergenicity in the legume botanical family in children with food hypersensitivity.

  1989cited by this paper
• Cross-allergenicity in the legume botanical family in children with food hypersensitivity. II. Laboratory correlates.

  1989cited by this paper
• The natural history of peanut allergy.

  1989cited by this paper
• Chemistry of Maillard reactions: recent studies on the browning reaction mechanism and the development of antioxidants and mutagens.

  1988cited by this paper
• Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

  1986cited by this paper
• Allergy in the newborn: skin test reactions confirmed by the Prausnitz‐Küstner test at birth

  1971cited by this paper
• Ana o 1 , a cashew ( Anacardium occidental ) allergen of the vicilin seed storage protein family

  year unknowncited by this paper

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  2016cites this paper
• Oral Immunotherapy for Peanut Allergy.

  2016cites this paper
• Peptide-based allergen specific immunotherapy for the treatment of allergic disorders.

  2015cites this paper
• Detection of Ara h 1 (a major peanut allergen) in food using an electrochemical gold nanoparticle-coated screen-printed immunosensor.

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• The innate response to peanut extract in ovine afferent lymph and its correlation with allergen sensitisation

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• Animal Models of Allergic Diseases

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• Dietary assumption of plant polyphenols and prevention of allergy.

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• Hydrolysates of glycated and heat‐treated peanut 7S globulin (Ara h 1) modulate human gut microbial proliferation, survival and adhesion

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• In vitro Laboratory Tests for the Diagnosis of Allergy

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  2008cites this paper
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• Genetic engineering for removing food allergens from plants.

  2008cites this paper
• Peanut allergy: emerging concepts and approaches for an apparent epidemic.

  2007cites this paper
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  2007cites this paper
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