Chromosomal signatures of a subset of high-grade premalignant cervical lesions closely resemble invasive carcinomas.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Cancer Research

• Publication date

  2009-01-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1158/0008-5472.CAN-08-2478PMID 19147580
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• P16INK4a immunohistochemistry improves the reproducibility of the histological diagnosis of cervical intraepithelial neoplasia in cone biopsies.

  2008cited by this paper
• p16ink4a and HPV L1 Immunohistochemistry is Helpful for Estimating the Behavior of Low-grade Dysplastic Lesions of the Cervix Uteri

  2008cited by this paper
• CGHcall: Calling aberrations for array CGH tumor profiles.

  2008cited by this paper
• Association between dense CADM1 promoter methylation and reduced protein expression in high‐grade CIN and cervical SCC

  2008influential reference
• Integrated genomic and transcriptional profiling identifies chromosomal loci with altered gene expression in cervical cancer

  2008cited by this paper
• Natural history of cervical neoplasia and risk of invasive cancer in women with cervical intraepithelial neoplasia 3: a retrospective cohort study.

  2008cited by this paper
• Weighted clustering of called array CGH data.

  2008cited by this paper
• Biomarkers in Cervical Cancer Screening

  2007cited by this paper
• Impact of utilizing p16INK4A immunohistochemistry on estimated performance of three cervical cancer screening tests

  2007cited by this paper
• CGHregions: Dimension Reduction for Array CGH Data with Minimal Information Loss

  2007cited by this paper
• CGHcall: calling aberrations for array CGH tumor profiles

  2007cited by this paper
• p16INK4A expression in cervical premalignant and malignant lesions.

  2006cited by this paper
• HPV‐mediated cervical carcinogenesis: concepts and clinical implications

  2006cited by this paper
• Increased gene copy numbers at chromosome 20q are frequent in both squamous cell carcinomas and adenocarcinomas of the cervix

  2006influential reference
• Treatment for Cervical Intraepithelial Neoplasia and Risk of Preterm DeliverySadler L, Saftlas A, Wang W, et al (Univ of Auckland, New Zealand; Natl Women's Hosp, Auckland, New Zealand; Univ of Iowa, Iowa City) JAMA 291:2100–2106, 2004§

  2006cited by this paper
• P16(INK4a) expression as a potential prognostic marker in cervical pre-neoplastic and neoplastic lesions.

  2006cited by this paper
• Molecular biology of human papillomavirus infection and cervical cancer.

  2006cited by this paper
• Genomic amplification of the human telomerase gene (TERC) in pap smears predicts the development of cervical cancer.

  2005cited by this paper
• Generation and molecular characterization of head and neck squamous cell lines of fanconi anemia patients.

  2005cited by this paper
• Association between the stages of cervical cancer and chromosome 1 aneusomy.

  2005cited by this paper
• Amplification of the chromosome 20q region is associated with expression of HPV-16 E7 in human airway and anogenital epithelial cells.

  2005cited by this paper
• Development and duration of human papillomavirus lesions, after initial infection.

  2005cited by this paper
• Chromosomal instability in flat adenomas and carcinomas of the colon

  2005cited by this paper
• Genomic imbalances in 70 snap-frozen cervical squamous intraepithelial lesions: associations with lesion grade, state of the HPV16 E2 gene and clinical outcome

  2004cited by this paper
• TSLC1 gene silencing in cervical cancer cell lines and cervical neoplasia.

  2004cited by this paper
• P16INK4a expression and progression risk of low-grade intraepithelial neoplasia of the cervix uteri

  2004cited by this paper
• Detection of genomic amplification of the human telomerase gene (TERC) in cytologic specimens as a genetic test for the diagnosis of cervical dysplasia.

  2003cited by this paper
• Genetic analysis identifies putative tumor suppressor sites at 2q35–q36.1 and 2q36.3–q37.1 involved in cervical cancer progression

  2003cited by this paper
• Estimates of the world‐wide prevalence of cancer for 25 sites in the adult population

  2002cited by this paper
• Comparative genomic hybridization detects genetic alterations during early stages of cervical cancer progression

  2002cited by this paper
• Pathology of the Uterine Cervix, Vagina and Vulva

  2002cited by this paper
• p16INK4a Immunohistochemistry Improves Interobserver Agreement in the Diagnosis of Cervical Intraepithelial Neoplasia

  2002cited by this paper
• HPV presence precedes abnormal cytology in women developing cervical cancer and signals false negative smears

  2001cited by this paper
• Comparative genomic hybridization reveals non-random chromosomal aberrations in early preinvasive cervical lesions.

  2001cited by this paper
• Assembly of microarrays for genome-wide measurement of DNA copy number

  2001cited by this paper
• Overexpression of p16INK4A as a specific marker for dysplastic and neoplastic epithelial cells of the cervix uteri

  2001cited by this paper
• Numerical chromosomal aberrations of chromosome 1 and 7 in dysplastic cervical smears.

  2000cited by this paper
• Molecular Cloning of a Novel Human I-mfa Domain-containing Protein That Differently Regulates Human T-cell Leukemia Virus Type I and HIV-1 Expression*

  2000cited by this paper
• Comparative genomic hybridization reveals a recurrent pattern of chromosomal aberrations in severe dysplasia/carcinoma in situ of the cervix and in advanced‐stage cervical carcinoma

  1999cited by this paper
• DNA topoisomerase I in oncology: Dr Jekyll or Mr Hyde?

  1999cited by this paper
• Type-specific persistence of human papillomavirus DNA before the development of invasive cervical cancer.

  1999cited by this paper
• Molecular cytogenetics of primary breast cancer by CGH

  1998cited by this paper
• Non‐random allelic losses at 3p, 11p and 13q during HPV‐mediated immortalization and concomitant loss of terminal differentiation of human keratinocytes

  1998cited by this paper
• Inter‐ and intra‐observer variation in the histopathological reporting of cervical squamous in traepithelial lesion susing a modified Bethesda grading system

  1998cited by this paper
• Chromosomal duplication accompanies allelic loss in non-small cell lung carcinoma.

  1998cited by this paper
• Chromosomal aberrations associated with invasion in papillary superficial bladder cancer

  1998cited by this paper
• Telomerase activity exclusively in cervical carcinomas and a subset of cervical intraepithelial neoplasia grade III lesions: strong association with elevated messenger RNA levels of its catalytic subunit and high-risk human papillomavirus DNA.

  1998cited by this paper
• 20q gain associates with immortalization: 20q13.2 amplification correlates with genome instability in human papillomavirus 16 E7 transformed human uroepithelial cells

  1997cited by this paper
• A general primer GP5+/GP6(+)-mediated PCR-enzyme immunoassay method for rapid detection of 14 high-risk and 6 low-risk human papillomavirus genotypes in cervical scrapings

  1997cited by this paper
• Inhibition of cyclin D-CDK4/CDK6 activity is associated with an E2F-mediated induction of cyclin kinase inhibitor activity.

  1996cited by this paper
• Gain of chromosome 3q defines the transition from severe dysplasia to invasive carcinoma of the uterine cervix.

  1996cited by this paper
• Cervical Cytology by Means of Fluorescence in situ Hybridization with a Set of Chromosome‐Specific DNA Probes *

  1996cited by this paper
• Transition of human papillomavirus type 16 and 18 transfected human foreskin keratinocytes towards immortality: activation of telomerase and allele losses at 3p, 10p, 11q and/or 18q.

  1996cited by this paper
• Pathways of chromosome alteration in human epithelial cancers.

  1995cited by this paper
• Near‐haploid karyotype in a squamous cell lung carcinoma

  1993cited by this paper
• Cytogenetic and molecular approaches of polyploidization in colorectal adenocarcinomas.

  1990cited by this paper
• Chromosome 1 abnormalities in cervical carcinoma

  1988cited by this paper

• Human papilloma virus (HPV) mediated cancers: an insightful update

  2025cites this paper
• Shared gene signatures and molecular mechanisms link ankylosing spondylitis and rheumatoid arthritis

  2025cites this paper
• Molecular Insights Into the Natural History of Anal HSIL

  2025cites this paper
• DNA methylation and copy number alterations in the progression of HPV‐associated high‐grade vulvar intraepithelial lesion

  2025cites this paper
• Accurate detection of copy number aberrations in FFPE samples using the mFAST-SeqS approach.

  2024cites this paper
• DBD-FISH Using Specific Chromosomal Region Probes for the Study of Cervical Carcinoma Progression.

  2024cites this paper
• Methylation markers for anal cancer screening: A repeated cross‐sectional analysis of people living with HIV, 2015–2016

  2024cites this paper
• Disease progression role as well as the diagnostic and prognostic value of microRNA-21 in patients with cervical cancer: A systematic review and meta-analysis

  2022cites this paper
• Differential expression of microRNAs and their target genes in cervical intraepithelial neoplasias of varying severity

  2020cites this paper
• MICRO-RNA AS MARKERS OF PRE-CANCER DISEASES PROGRESSION IN CERVICAL CANCER

  2020cites this paper
• Cancer Risk Stratification of Anal Intraepithelial Neoplasia in Human Immunodeficiency Virus–Positive Men by Validated Methylation Markers Associated With Progression to Cancer

  2020cites this paper
• Human Papillomavirus, MicroRNA and their Role in Cervical Cancer Progression, Diagnosis and Treatment Response: A Comprehensive Review.

  2020cites this paper
• Cervical cancer risk profiling: molecular biomarkers predicting the outcome of hrHPV infection

  2020cites this paper
• 1p36 is a chromosomal site of genomic instability in cervical intraepithelial neoplasia

  2020cites this paper
• Human Papillomavirus

  2019cites this paper
• Molecular heterogeneity in human papillomavirus‐dependent and ‐independent vulvar carcinogenesis

  2018cites this paper
• Suppressive Effects of EGCG on Cervical Cancer

  2018cites this paper
• MicroRNAs as markers of progression in cervical cancer: a systematic review

  2018cites this paper
• Host Cell Deoxyribonucleic Acid Methylation Markers for the Detection of High-grade Anal Intraepithelial Neoplasia and Anal Cancer

  2018cites this paper
• SIRT1 overexpression in cervical squamous intraepithelial lesions and invasive squamous cell carcinoma.

  2017cites this paper
• CADM1 and MAL methylation status in cervical scrapes is representative of the most severe underlying lesion in women with multiple cervical biopsies

  2016cites this paper
• Molecular events leading to HPV-induced high grade neoplasia

  2016cites this paper
• YIP1 family member 4 (YIPF4) is a novel cellular binding partner of the papillomavirus E5 proteins

  2015cites this paper
• Cytogenetic Early Markers in Gynecologic Cancers

  2015cites this paper
• An Optimization-Driven Analysis Pipeline to Uncover Biomarkers and Signaling Paths: Cervix Cancer

  2015cites this paper
• 'Drawing' a Molecular Portrait of CIN and Cervical Cancer: a Review of Genome-Wide Molecular Profiling Data.

  2015cites this paper
• A Comprehensive Review of Dysregulated miRNAs Involved in Cervical Cancer

  2014cites this paper
• Genome-wide screening of DNA copy number alterations in cervical carcinoma patients with CGH+SNP microarrays and HPV-FISH.

  2014cites this paper
• Chromosomal gains and losses in human papillomavirus-associated neoplasia of the lower genital tract - a systematic review and meta-analysis.

  2014influential citation
• Expressão de genes de vias de reparo de dano ao DNA em células infectadas por papilomavírus humano (HPV)

  2014cites this paper
• papillomavirus-induced cervical lesions Brief Communication

  2013cites this paper
• Altered microRNA expression associated with chromosomal changes contributes to cervical carcinogenesis

  2013cites this paper
• Focal aberrations indicate EYA2 and hsa‐miR‐375 as oncogene and tumor suppressor in cervical carcinogenesis

  2013cites this paper
• CADM1 and MAL promoter methylation levels in hrHPV‐positive cervical scrapes increase proportional to degree and duration of underlying cervical disease

  2013cites this paper
• Individual karyotypes at the origins of cervical carcinomas

  2013cites this paper
• 5-bp Classical Satellite DNA Loci from Chromosome-1 Instability in Cervical Neoplasia Detected by DNA Breakage Detection/Fluorescence in Situ Hybridization (DBD-FISH)

  2013cites this paper
• Chromosomal gains measured in cytology samples from women with abnormal cervical cancer screening results.

  2013cites this paper
• Gene network reconstruction reveals cell cycle and antiviral genes as major drivers of cervical cancer

  2013cites this paper
• Diagnostic tests for the detection of human papillomavirus-associated cervical lesions.

  2013cites this paper
• Evaluation of the association of NKG2C copy number variations with susceptibility to human papillomavirus-induced cervical lesions.

  2013cites this paper
• Identification of eight candidate target genes of the recurrent 3p12–p14 loss in cervical cancer by integrative genomic profiling

  2013cites this paper
• HPV type-related chromosomal profiles in high-grade cervical intraepithelial neoplasia

  2012influential citation
• The biology and life-cycle of human papillomaviruses.

  2012cites this paper
• 3q26 Amplification Is an Effective Negative Triage Test for LSIL: A Historical Prospective Study

  2012cites this paper
• Chromosomal profiles of high‐grade cervical intraepithelial neoplasia relate to duration of preceding high‐risk human papillomavirus infection

  2012cites this paper
• Biomarkers for cervical cancer screening: the role of p16INK4a to highlight transforming HPV infections

  2012cites this paper
• Chapter 6 CADM 1 and MAL promoter methylation levels in hrHPV-positive cervical scrapes increase proportional to degree and duration of underlying cervical disease

  2012cites this paper
• Oncogenic human papillomavirus imposes an instructive pattern of DNA methylation changes which parallel the natural history of cervical HPV infection in young women.

  2012cites this paper
• Different amplification patterns of the human telomerase RNA gene in invasive cervical carcinomas and cervical intraepithelial neoplasia grade III

  2012cites this paper
• Differential DNA copy number aberrations in the progression of cervical lesions to invasive cervical carcinoma.

  2012cites this paper
• Genetic alterations in cervical cancer : consequences for gene regulation and clinical outcome after chemoradiotherapy

  2011cites this paper
• Solid tumor cytogenetics: current perspectives.

  2011cites this paper
• Combined Promoter Methylation Analysis of CADM1 and MAL: An Objective Triage Tool for High-Risk Human Papillomavirus DNA–Positive Women

  2011cites this paper
• miR-124a is frequently down-regulated in glioblastoma and is involved in migration and invasion.

  2011cites this paper
• Running title: Methylation markers to triage hrHPV-positive women

  2011cites this paper
• Association of polymorphism in FcGR3A gene and progression of low-grade precursor lesions of cervical carcinoma.

  2010cites this paper
• Integrative genomic approaches in cervical cancer: implications for molecular pathogenesis.

  2010cites this paper
• ZBRK1 acts as a metastatic suppressor by directly regulating MMP9 in cervical cancer.

  2010cites this paper
• Tumorigenesis and Neoplastic Progression Epigenetic Silencing of a Proapoptotic Cell Adhesion Molecule , the Immunoglobulin Superfamily Member IGSF 4 , by Promoter CpG Methylation Protects Hodgkin Lymphoma Cells from Apoptosis

  2010cites this paper
• Detection of DNA hypermethylation as a diagnostic tool in cervical neoplasma tool in cervical neoplasia

  2010cites this paper
• HPV-Mediated Genome Instability: At the Roots of Cervical Carcinogenesis

  2010cites this paper
• Epigenetic silencing of a proapoptotic cell adhesion molecule, the immunoglobulin superfamily member IGSF4, by promoter CpG methylation protects Hodgkin lymphoma cells from apoptosis.

  2010cites this paper
• Detection of DNA hypermethylation as a diagnostic tool in cervical neoplasma tool in cervical neoplasia

  2010cites this paper
• SOX2 Is an Oncogene Activated by Recurrent 3q26.3 Amplifications in Human Lung Squamous Cell Carcinomas

  2010cites this paper
• suMMarY, disCussiOn and future perspeCtives

  2010cites this paper
• Validation of high-risk HPV tests for primary cervical screening.

  2009cites this paper
• ZBRK 1 Acts as a Metastatic Suppressor by Directly Regulating MMP 9 in Cervical Cancer

  2009cites this paper
• Gene Dosage, Expression, and Ontology Analysis Identifies Driver Genes in the Carcinogenesis and Chemoradioresistance of Cervical Cancer

  2009cites this paper