2,3-epoxy-4-hydroxynonanal, a potential lipid peroxidation product for etheno adduct formation, is not a substrate of human epoxide hydrolase.

No abstract is available for this paper.

• Publication year

  1998

• Venue

  Carcinogenesis

• Publication date

  1998-05-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1093/CARCIN/19.5.939PMID 9635886
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Aflatoxin B1 8,9-epoxide hydrolysis in the presence of rat and human epoxide hydrolase.

  1997cited by this paper
• Epoxidation of trans-4-hydroxy-2-nonenal by fatty acid hydroperoxides and hydrogen peroxide.

  1996cited by this paper
• Lipid peroxidation as a potential endogenous source for the formation of exocyclic DNA adducts.

  1996cited by this paper
• Susceptibility to hepatocellular carcinoma is associated with genetic variation in the enzymatic detoxification of aflatoxin B1.

  1995cited by this paper
• Dose-response relationships for carcinogens.

  1995cited by this paper
• Mercapturic acid conjugates as urinary end metabolites of the lipid peroxidation product 4-hydroxy-2-nonenal in the rat.

  1995cited by this paper
• Determination of aldehydic lipid peroxidation products with dabsylhydrazine by high-performance liquid chromatography

  1995cited by this paper
• 1,N6-ethenodeoxyadenosine and 3,N4-ethenodeoxycytine in liver DNA from humans and untreated rodents detected by immunoaffinity/32P-postlabeling.

  1995cited by this paper
• Detection of endogenous malondialdehyde-deoxyguanosine adducts in human liver

  1995cited by this paper
• Detection of endogenous malondialdehyde-deoxyguanosine adducts in human liver.

  1994cited by this paper
• Detection of exocyclic 1,N2-propanodeoxyguanosine adducts as common DNA lesions in rodents and humans.

  1994cited by this paper
• Formation of etheno adducts in reactions of enals via autoxidation.

  1994cited by this paper
• The role of 12 cDNA‐expressed human, rodent, and rabbit cytochromes P450 in the metabolism of benzo[a]pyrene and benzo[a]pyrene trans‐7, 8‐dihydrodiol

  1994cited by this paper
• Metabolism of 4-hydroxynonenal, a cytotoxic lipid peroxidation product, in Ehrlich mouse ascites cells at different proliferation stages.

  1994cited by this paper
• Species differences in the hydrolysis of 2-cyanoethylene oxide, the epoxide metabolite of acrylonitrile.

  1993cited by this paper
• Formation of 1,N2- and N2,3-ethenoguanine from 2-halooxiranes: isotopic labeling studies and isolation of a hemiaminal derivative of N2-(2-oxoethyl)guanine.

  1993cited by this paper
• 2,3-epoxy-4-hydroxynonanal as a potential tumor-initiating agent of lipid peroxidation.

  1993cited by this paper
• Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes.

  1991cited by this paper
• Stereoselective formation of in vitro nucleic acid adducts by 2,3-epoxy-4-hydroxynonanal.

  1991cited by this paper
• Expression of mammalian cytochrome P450 using vaccinia virus.

  1991cited by this paper
• Species comparison of acrylonitrile epoxidation by microsomes from mice, rats and humans: relationship to epoxide concentrations in mouse and rat blood.

  1991cited by this paper
• The Ah locus: genetic differences in toxicity, cancer, mutation, and birth defects.

  1989cited by this paper
• Structural characterization of adducts formed in the reaction of 2,3-epoxy-4-hydroxynonanal with deoxyguanosine.

  1989cited by this paper
• Cell-Catalyzed Binding of 3H-(–)-trans-7, 8-Dihydroxy-7, 8-dihydrobenzo[a]pyrene to Cellular and Exogenous DNA and the Role of Purified Human Liver Epoxide Hydrolase

  1988cited by this paper
• Human microsomal xenobiotic epoxide hydrolase. Complementary DNA sequence, complementary DNA-directed expression in COS-1 cells, and chromosomal localization.

  1988cited by this paper
• 1,N2-ethenodeoxyguanosine as a potential marker for DNA adduct formation by trans-4-hydroxy-2-nonenal.

  1988cited by this paper
• Cell-catalyzed binding of 3H-(-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene to cellular and exogenous DNA and the role of purified human liver epoxide hydrolase.

  1988cited by this paper
• Ring-extended products from the reaction of epoxy carbonyl compounds and nucleic acid bases

  1985cited by this paper
• Separation and characterization of the aldehydic products of lipid peroxidation stimulated by carbon tetrachloride or ADP-iron in isolated rat hepatocytes and rat liver microsomal suspensions.

  1985cited by this paper
• Vaccinia virus expression vector: coexpression of beta-galactosidase provides visual screening of recombinant virus plaques

  1985cited by this paper
• Purification and characterization of six cytochrome P-450 isozymes from human liver microsomes.

  1983cited by this paper
• Identification of 4-hydroxynonenal as a cytotoxic product originating from the peroxidation of liver microsomal lipids.

  1980cited by this paper
• Molecular properties and biological functions of microsomal epoxide hydrase.

  1980cited by this paper
• Rat and human liver microsomal epoxide hydratase. Purification and evidence for the existence of multiple forms.

  1979cited by this paper
• Mammalian epoxide hydrases: inducible enzymes catalysing the inactivation of carcinogenic and cytotoxic metabolites derived from aromatic and olefinic compounds.

  1973cited by this paper
• Protein measurement with the Folin phenol reagent.

  1951cited by this paper

• The colors of peroxygenase activity: Colorimetric high-throughput screening assays for directed evolution.

  2023cites this paper
• Endogenous aldehyde accumulation generates genotoxicity and exhaled biomarkers in esophageal adenocarcinoma

  2021cites this paper
• Formation of Bulky DNA Adducts by Non-Enzymatic Production of 1,2-Naphthoquinone-Epoxide from 1,2-Naphthoquinone under Physiological Conditions.

  2019cites this paper
• Redox Signaling by Reactive Electrophiles and Oxidants.

  2018cites this paper
• Antioxidants: Reviewing the chemistry, food applications, legislation and role as preservatives

  2018cites this paper
• Genotoxicity of lipid oxidation compounds

  2017cites this paper
• Cytochrome c and resveratrol preserve platelet function during cold storage

  2017cites this paper
• DNA damage by lipid peroxidation products: implications in cancer, inflammation and autoimmunity

  2017cites this paper
• Lipid Peroxidation, Diet, and the Genotoxicology of Aging

  2016cites this paper
• 4-Hydroxy-nonenal—A Bioactive Lipid Peroxidation Product

  2015cites this paper
• Evaluation of assays for epoxides in oxidized lipids

  2013cites this paper
• Human aldo-keto reductase AKR7A2 protects against the cytotoxicity and mutagenicity of reactive aldehydes and lowers intracellular reactive oxygen species in hamster V79-4 cells.

  2012cites this paper
• The protective role of antioxidants and the aldo-keto reductase AKR7A2 against toxic aldehydes in cell lines

  2012cites this paper
• Neurochemical Aspects of 4-Hydroxynonenal

  2011cites this paper
• Chemistry and biochemistry of lipid peroxidation products

  2010cites this paper
• 4‐Hydroxynonenal: A membrane lipid oxidation product of medicinal interest

  2008cites this paper
• Toxic Oxygenated α,β-Unsaturated Aldehydes and their Study in Foods: A Review

  2008cites this paper
• Oxidized phospholipids: from molecular properties to disease.

  2007cites this paper
• Mechanism of 1,N2-etheno-2'-deoxyguanosine formation from epoxyaldehydes.

  2007cites this paper
• The comparison of effect of catechins and green tea extract on oxidative modification of LDL in vitro.

  2006cites this paper
• Over-expression of different aldehyde dehydrogenase genes in Arabidopsis thaliana confers tolerance to abiotic stress and protects plants against lipid peroxidation and oxidative stress.

  2006cites this paper
• Site specific synthesis and polymerase bypass of oligonucleotides containing a 6-hydroxy-3,5,6,7-tetrahydro-9H-imidazo[1,2-a]purin-9-one base, an intermediate in the formation of 1,N2-etheno-2'-deoxyguanosine.

  2005cites this paper
• Urinary excretion of 3,N4-etheno-2'-deoxycytidine in humans as a biomarker of oxidative stress: association with cigarette smoking.

  2004cites this paper
• Basic aspects of the biochemical reactivity of 4-hydroxynonenal.

  2003cites this paper
• Effect of cigarette smoking on urinary 3,N4-ethenocytosine levels measured by gas chromatography/mass spectrometry.

  2003cites this paper
• Effect of Cigarette Smoking on Urinary 3 , N 4-Ethenocytosine Levels Measured by Gas Chromatography / Mass Spectrometry

  2003cites this paper
• 4‐Hydroxynonenal in the Pathomechanisms of Oxidative Stress

  2000cites this paper