High-resolution neutron protein crystallography with radically small crystal volumes: application of perdeuteration to human aldose reductase.

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Acta Crystallographica Section D: Biological Crystallography

• Publication date

  2005-10-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1107/S0907444905024285PMID 16204895
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Production and X-ray crystallographic analysis of fully deuterated cytochrome P450cam.

  2005cited by this paper
• Production and preliminary analysis of perdeuterated yeast inorganic pyrophosphatase crystals suitable for neutron diffraction.

  2004cited by this paper
• Subatomic and atomic crystallographic studies of aldose reductase: implications for inhibitor binding

  2004cited by this paper
• All in the family: aldose reductase and closely related aldo-keto reductases

  2004cited by this paper
• Structural stability and dynamics of hydrogenated and perdeuterated cytochrome P450cam (CYP101).

  2004cited by this paper
• Ultrahigh resolution drug design I: Details of interactions in human aldose reductase–inhibitor complex at 0.66 Å

  2004cited by this paper
• Ultrahigh resolution drug design. II. Atomic resolution structures of human aldose reductase holoenzyme complexed with fidarestat and minalrestat: Implications for the binding of cyclic imide inhibitors

  2004cited by this paper
• The crystallographic structure of the aldose reductase-IDD552 complex shows direct proton donation from tyrosine 48.

  2004cited by this paper
• Aldose reductase structures: implications for mechanism and inhibition

  2004cited by this paper
• The 15-K neutron structure of saccharide-free concanavalin A.

  2004cited by this paper
• Enhanced visibility of hydrogen atoms by neutron crystallography on fully deuterated myoglobin.

  2000cited by this paper
• Direct determination of the positions of the deuterium atoms of the bound water in -concanavalin A by neutron Laue crystallography.

  2000cited by this paper
• LSCALE - the new normalization, scaling and absorption correction program in the Daresbury Laue software suite

  1999cited by this paper
• LAUEGEN version 6.0 and INTLDM

  1998cited by this paper
• A low-resolution low-temperature neutron diffraction study of myoglobin.

  1997cited by this paper
• LAUEGEN, an X-windows-based program for the processing of Laue diffraction data

  1995cited by this paper
• The production and X-ray structure determination of perdeuterated Staphylococcal nuclease.

  1994cited by this paper
• Repulsive restraints for hydrogen bonding in least‐squares refinement of protein crystals. A neutron diffraction study of myoglobin crystals

  1991cited by this paper
• The recording and analysis of synchrotron X-radiation Laue diffraction photographs

  1989cited by this paper
• Herpesvirus-transformed cytotoxic T-cell lines

  1981cited by this paper
• Neutron diffraction identifies His 57 as the catalytic base in trypsin

  1980cited by this paper
• Neutron Diffraction Analysis of Myoglobin

  1969cited by this paper

• The nature of dynamic local order in CH3NH3PbI3 and CH3NH3PbBr3

  2023cites this paper
• Aldose reductase inhibition alleviates diabetic cardiomyopathy and is associated with a decrease in myocardial fatty acid oxidation

  2023cites this paper
• Current status of neutron crystallography in structural biology

  2022cites this paper
• Metalloprotein catalysis: structural and mechanistic insights into oxidoreductases from neutron protein crystallography

  2021cites this paper
• The impact of folding modes and deuteration on the atomic resolution structure of hen egg-white lysozyme

  2021cites this paper
• Structural insights into protein folding, stability and activity using in vivo perdeuteration of hen egg-white lysozyme

  2021cites this paper
• Complementary Information from Neutron Crystallography Studies

  2020cites this paper
• Characterization of perdeuterated high‐potential iron‐sulfur protein with high‐resolution X‐ray crystallography

  2020cites this paper
• The role of hydrogen atoms in redox catalysis by the flavoenzyme cholesterol oxidase.

  2020cites this paper
• Large crystal growth for neutron protein crystallography.

  2020cites this paper
• Crystal structure of the S65T/F99S/M153T/V163A variant of perdeuterated GFP at pD 8.5

  2019cites this paper
• X-ray crystallographic studies on the hydrogen isotope effects of green fluorescent protein at sub-ångström resolutions.

  2019cites this paper
• Perdeuteration of Biological Macromolecules: A Case Study of Human Carbonic Anhydrases

  2019cites this paper
• Neutron macromolecular crystallography.

  2018cites this paper
• Ligand-based drug design of novel aldose reductase inhibitors.

  2018cites this paper
• Advanced Nuclear and Related Techniques for Metallomics and Nanometallomics.

  2018cites this paper
• Neutron scattering in the biological sciences: progress and prospects.

  2018cites this paper
• Fifteen years of the Protein Crystallography Station: the coming of age of macromolecular neutron crystallography

  2017cites this paper
• Neutron protein crystallography: A complementary tool for locating hydrogens in proteins.

  2016cites this paper
• Biomolecular Deuteration for Neutron Structural Biology and Dynamics.

  2016cites this paper
• Preparation and Crystallization of Perdeuterated T4 Phage Lysozyme for Neutron Diffraction Study

  2015cites this paper
• Robust high-yield methodologies for (2)H and (2)H/(15)N/(13)C labeling of proteins for structural investigations using neutron scattering and NMR.

  2015cites this paper
• The Macromolecular Neutron Diffractometer MaNDi at the Spallation Neutron Source

  2015cites this paper
• Looking for Hydrogen Atoms: Neutron Crystallography Provides Novel Insights Into Protein Structure and Function

  2014cites this paper
• Binding site asymmetry in human transthyretin: insights from a joint neutron and X-ray crystallographic analysis using perdeuterated protein

  2014cites this paper
• Perdeuteration: improved visualization of solvent structure in neutron macromolecular crystallography.

  2014cites this paper
• A historical perspective on protein crystallization from 1840 to the present day

  2013cites this paper
• A neutron reflection study of adsorbed deuterated myoglobin layers on hydrophobic surfaces.

  2013cites this paper
• Neutron Scattering Techniques and Applications in Structural Biology

  2013influential citation
• Diffraction and Scattering by X-Rays and Neutrons

  2013cites this paper
• Neutron reflectometry elucidates density profiles of deuterated proteins adsorbed onto surfaces displaying poly(ethylene glycol) brushes: evidence for primary adsorption.

  2013cites this paper
• Joint X-ray/neutron crystallographic study of HIV-1 protease with clinical inhibitor amprenavir: insights for drug design.

  2013cites this paper
• Structure and regulation of aspartate pathway enzymes and deuteration effects on protein structure.

  2011cites this paper
• Structural Analysis of Active Site Conformations in Ras and Rap1 GTPases.

  2011cites this paper
• Time-of-flight neutron diffraction study of bovine γ-chymotrypsin at the Protein Crystallography Station.

  2011cites this paper
• Neutron Diffraction Experiments for Protein

  2010cites this paper
• Hemoglobin redux: combining neutron and X-ray diffraction with mass spectrometry to analyse the quaternary state of oxidized hemoglobins.

  2010cites this paper
• Joint X-ray and neutron refinement with phenix.refine.

  2010cites this paper
• X-ray structure of perdeuterated diisopropyl fluorophosphatase (DFPase): perdeuteration of proteins for neutron diffraction.

  2010cites this paper
• Unambiguous determination of H-atom positions: comparing results from neutron and high-resolution X-ray crystallography.

  2010influential citation
• New computational tools for H/D determination in macromolecular structures from neutron data.

  2010cites this paper
• Neutron macromolecular crystallography with LADI-III.

  2010cites this paper
• Design of a novel Peltier-based cooling device and its use in neutron diffraction data collection of perdeuterated yeast pyrophosphatase

  2010cites this paper
• Enzyme molecular choreography : studies on soluble inorganic pyrophosphatases

  2009cites this paper
• Large crystal growth by thermal control allows combined X-ray and neutron crystallographic studies to elucidate the protonation states in Aspergillus flavus urate oxidase

  2009cites this paper
• Perdeuteration, purification, crystallization and preliminary neutron diffraction of an ocean pout type III antifreeze protein.

  2009cites this paper
• Deuterium labeling for neutron structure-function-dynamics analysis.

  2009cites this paper
• A preliminary neutron diffraction study of gamma-chymotrypsin.

  2009cites this paper
• Neutron macromolecular crystallography

  2009influential citation
• A preliminary neutron crystallographic study of an A-DNA crystal.

  2009cites this paper
• The catalytic mechanism of an aspartic proteinase explored with neutron and X-ray diffraction.

  2008cites this paper
• New sources and instrumentation for neutrons in biology.

  2008cites this paper
• An investigation into the protonation states of the C1 domain of cardiac myosin-binding protein C.

  2008cites this paper
• On the determinants of amide backbone exchange in proteins: a neutron crystallographic comparative study.

  2008cites this paper
• Selective deuteration of tryptophan and methionine residues in maltose binding protein: a model system for neutron scattering

  2008cites this paper
• Quantum model of catalysis based on a mobile proton revealed by subatomic x-ray and neutron diffraction studies of h-aldose reductase

  2008influential citation
• Neutron protein crystallography: beyond the folding structure of biological macromolecules.

  2008influential citation
• An investigation into structural changes due to deuteration.

  2008cites this paper
• Expression, purification, assay, and crystal structure of perdeuterated human arginase I.

  2007cites this paper
• A methodology and an instrument for the temperature-controlled optimization of crystal growth.

  2007cites this paper
• The effect of deuteration on protein structure: a high-resolution comparison of hydrogenous and perdeuterated haloalkane dehalogenase.

  2007cites this paper
• Preliminary time-of-flight neutron diffraction study on diisopropyl fluorophosphatase (DFPase) from Loligo vulgaris.

  2007cites this paper
• Structural Biology of P450-Oxy Complexes

  2007cites this paper
• Advanced nuclear analytical techniques for metalloproteomics

  2007cites this paper
• Optimizing crystal volume for neutron diffraction: D-xylose isomerase

  2006cites this paper
• Neutron protein crystallography: current status and a brighter future.

  2006cites this paper
• Comparison of hydrogen determination with X-ray and neutron crystallography in a human aldose reductase–inhibitor complex

  2006cites this paper
• Prediction of protonation states in ligand-protein complexes upon ligand binding

  2006cites this paper
• Neutrons in biology: Institut Laue – Langevin, 4–7 September 2005

  2006cites this paper
• Neutron Protein Crystallography: Technical Aspects and Some Case Studies at Current Capabilities and Beyond

  2006cites this paper
• Neutron Laue macromolecular crystallography

  2006influential citation