Endogenous opiates, opioids, and immune function: evolutionary brokerage of defensive behaviors.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Seminars in Cancer Biology

• Publication date

  2008-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.semcancer.2007.12.001PMID 18191410
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Identification of five mouse mu-opioid receptor (MOR) gene (Oprm1) splice variants containing a newly identified alternatively spliced exon.

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• Endogenous morphine synthetic pathway preceded and gave rise to catecholamine synthesis in evolution (Review).

  2007cited by this paper
• Persistence of evolutionary memory: primordial six-transmembrane helical domain mu opiate receptors selectively linked to endogenous morphine signaling.

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• De novo biosynthesis of morphine in animal cells: an evidence-based model.

  2006cited by this paper
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• Identification of Morphine-6-glucuronide in Chromaffin Cell Secretory Granules*

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• The Neurobiology of Love.

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  2005cited by this paper
• Tyrosine and tyramine increase endogenous ganglionic morphine and dopamine levels in vitro and in vivo: cyp2d6 and tyrosine hydroxylase modulation demonstrates a dopamine coupling.

  2005cited by this paper
• Endogenous formation of morphine in human cells.

  2004cited by this paper
• The neurobiology of pleasure, reward processes, addiction and their health implications.

  2004cited by this paper
• Molecular Identification and Functional Expression of μ3, a Novel Alternatively Spliced Variant of the Human μ Opiate Receptor Gene1

  2003cited by this paper
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  2002cited by this paper
• A Membrane-proximal Basic Domain and Cysteine Cluster in the C-terminal Tail of CCR5 Constitute a Bipartite Motif Critical for Cell Surface Expression*

  2001cited by this paper
• Generation of the mu opioid receptor (MOR-1) protein by three new splice variants of the Oprm gene

  2001cited by this paper
• Ischemic preconditioning - an opiate constitutive nitric oxide molecular hypothesis.

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• Rebound from Nitric Oxide Inhibition Triggers Enhanced Monocyte Activation and Chemotaxis1

  2000cited by this paper
• Proenkephalin A-derived peptides in invertebrate innate immune processes.

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• Morphine suppresses complement receptor expression, phagocytosis, and respiratory burst in neutrophils by a nitric oxide and mu(3) opiate receptor-dependent mechanism.

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  1996cited by this paper
• The C-terminal bisphosphorylated proenkephalin-A-(209-237)-peptide from adrenal medullary chromaffin granules possesses antibacterial activity.

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• Opioid and opiate immunoregulatory processes.

  1996cited by this paper
• Morphine stimulates nitric oxide release from invertebrate microglia.

  1996cited by this paper
• Opioid analgesics and antagonists

  1996cited by this paper
• Effect of prolonged exposure to morphine on responsiveness of human and invertebrate immunocytes to stimulatory molecules.

  1995cited by this paper
• Modulation of endogenous opiate production: effect of fasting.

  1995cited by this paper
• Isolation and structural characterization of enkephalins in the brain of the Rhynchobdellid leech Theromyzon tessulatum

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• Antagonizing effect of morphine on the mobility and phagocytic activity of invertebrate immunocytes.

  1995cited by this paper
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• Local analgesic effect of endogenous opioid peptides.

  1993cited by this paper
• Neuroimmune implications of cardiopulmonary bypass

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• Consequences of opiate-dependency in a monkey model of AIDS.

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• Neuroimmunomodulation by opiates: relationship to HIV-1 infection and AIDS

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• Interleukin-10.

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• Human neutrophil and macrophage chemokinesis induced by cardiopulmonary bypass: loss of DAME and IL-1 chemotaxis.

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• Biological properties of interleukin 10.

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• [D-Ala2]deltorphin I binding and pharmacological evidence for a special subtype of delta opioid receptor on human and invertebrate immune cells.

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• Opioids depress in vitro human monocyte chemotaxis.

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• Corticotropin-releasing factor-induced immunosuppression in human and invertebrate immunocytes

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