The Catabolism of Plasma Albumin in the Rabbit

From I131-albumin studies and previously defined mathematical formulations, rates of breakdown were estimated for native plasma albumin in rabbits. These rates of catabolism per unit weight of animal were remarkably constant and were independent of variations in the steady state values of albumin concentration in the plasma. These results imply that, at least between animals, the breakdown of plasma albumin follows a kinetic process of approximately zero order. It seems plausible that the process operates similarly in individual animals, and hence that albumin is maintained at normal steady state levels in the healthy animal primarily by means of a regulated rate of synthesis.

• Publication year

  1959

• Venue

  The Journal of General Physiology

• Publication date

  1959-11-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1085/JGP.43.2.445PMID 14436923PMCID 2194984
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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