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Analysis of behaviour in the Active Allothetic Place Avoidance task based on cluster analysis of the rat movement motifs

Tiago V. Gehring,M. Węsierska,D. Wójcik,E. Vasilaki

Published 2017 in bioRxiv

ABSTRACT

The Active Allothetic Place Avoidance test (AAPA) is a useful tool to study spatial memory in a dynamic world. In this task a rat, freely moving on a rotating circular arena, has to avoid a sector where shocks are presented. The standard analysis of memory performance in the AAPA task relies on evaluating individual performance measures. Here we present a new method of analysis for the AAPA test that focuses on the movement paths of the animals and utilizes a clustering algorithm to automatically extract the stereotypical types of behaviour as reflected in the recorded paths. We apply the method to experiments that study the effect of silver nanoparticles (AgNPs) on the reference memory and identify six major classes of movement motifs not previously described in AAPA tests. The method allows us to analyse the data with no prior expectations about the motion to be seen in the experiments.

PUBLICATION RECORD

  • Publication year

    2017

  • Venue

    bioRxiv

  • Publication date

    2017-06-30

  • Fields of study

    Biology, Computer Science

  • Identifiers
    DOI 10.1101/157859
  • External record

    Open on Semantic Scholar

  • Source metadata

    Semantic Scholar

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