Breast cancer personalized medicine: challenges and opportunities.

The perplex-ing challenge of patient management for the clinician is re-flected in the observation that among breast cancer patientswith similar disease (based on traditional histopathologicalmeasures) and similar therapeutic strategy, some patientswill be cured (and thereafter live a normal lifespan) whereasothers will progress to premature death. In fact, we nowrecognize that breast cancer is tremendously complex in itsmolecular pathogenesis, natural history, and biology.

• Publication year

  2013

• Venue

  American Journal of Pathology

• Publication date

  2013-10-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/j.ajpath.2013.08.001PMID 23978519
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Targeted therapy for breast cancer.

  2013cited by this paper
• Inherited genetic susceptibility to breast cancer: the beginning of the end or the end of the beginning?

  2013cited by this paper
• Molecular and cellular heterogeneity in breast cancer: challenges for personalized medicine.

  2013cited by this paper
• The emerging role of the molecular diagnostics laboratory in breast cancer personalized medicine.

  2013cited by this paper
• Genomic medicine frontier in human solid tumors: prospects and challenges.

  2013cited by this paper
• Triple-negative breast cancer and the need for new therapeutic targets.

  2013cited by this paper
• Epigenetic modifications in breast cancer and their role in personalized medicine.

  2013cited by this paper
• Breast cancer metastasis: issues for the personalization of its prevention and treatment.

  2013cited by this paper
• Personalized health care: From theory to practice

  2012cited by this paper
• How many molecular subtypes? Implications of the unique tumor principle in personalized medicine

  2012cited by this paper
• Targeted Therapy in Breast Cancer

  2010cited by this paper
• Breast cancer: origins and evolution.

  2007cited by this paper
• Polygenic inherited predisposition to breast cancer.

  2005cited by this paper
• Ovarian and breast cancer risks to women in families with two or more cases of ovarian cancer

  2000cited by this paper
• The Genetics of Inherited Breast Cancer

  1998cited by this paper
• Breast cancer epidemiology.

  1988cited by this paper

• Preventive, Personalized, and Precision Medicine and Biomarkers for Breast Cancer Diagnosis: Artificial Intelligence Framework

  2025cites this paper
• Advancing Breast Cancer Management Through an Enhanced Understanding of Disease Heterogeneity from Initiation to Metastasis.

  2025cites this paper
• Cancer mRNA Vaccines as a Promising Approach for Treating Luminal A Breast Cancer

  2022cites this paper
• Epigenome modulated xenobiotic detoxification pathways control DMBA-induced breast cancer in agouti Avy/a mice

  2019cites this paper
• Cell-free circulating tumor DNA analysis for breast cancer and its clinical utilization as a biomarker

  2017cites this paper
• Immunocompetent mouse allograft models for development of therapies to target breast cancer metastasis

  2017cites this paper
• Pattern of RECK CpG methylation as a potential marker for predicting breast cancer prognosis and drug-sensitivity

  2016cites this paper
• Her2 oncogene transformation enhances 5-aminolevulinic acid-mediated protoporphyrin IX production and photodynamic therapy response

  2016cites this paper
• Lipid-sensors, enigmatic-orphan and orphan nuclear receptors as therapeutic targets in breast-cancer

  2016cites this paper
• Personalized Medicines: Reforming Diagnostics and Therapeutics

  2015cites this paper
• COST BENEFIT ANALYSIS OF PERSONALIZED HEALTHCARE DELIVERY FOR BREAST CANCER PATIENTS A Thesis Presented By

  2015cites this paper
• Degeneracy: Demystifying and destigmatizing a core concept in systems biology

  2015cites this paper
• Rebooted: AJP Version 2.014

  2014cites this paper
• Characterization of murine and human breast cancer stem cells in vitro and in vivo

  2014cites this paper
• Molecular profiling and companion diagnostics: where is personalized medicine in cancer heading?

  2014cites this paper