Chemical constituents from Bauhinia acuruana and their cytotoxicity

Phytochemical investigation of Bauhinia acuruana Moric., Fabaceae, resulted in the isolation of sixteen constituents, including two new compounds 2′-hydroxy-2,3,5-trimethoxybibenzyl ( 1 ), (2R,3S)-2-(3,4′-dihydroxyphenyl)-5-methoxy-6-methylchroman-3,7-diol ( 2 ), together with fourteen known ones ( 3–16 ). The structures of the compounds were established by spectroscopic analysis including HR-ESIMS, 1D and 2D NMR data, followed by comparison with previously reported data from the literature. Compounds 1, 2, 6, 7, 8 and 9 were evaluated for their cytotoxicity, which turned out to be marginal in a panel of six human cancer cell lines.

• Publication year

  2017

• Venue

  Revista Brasileira de Farmacognosia

• Publication date

  2017-11-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/J.BJP.2017.09.002
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• New Cytotoxic Bibenzyl and Other Constituents from Bauhinia ungulata L. (Fabaceae)

  2016cited by this paper
• Cytotoxic bibenzyl dimers from the stems of Dendrobium fimbriatum Hook.

  2014cited by this paper
• Cytotoxic prenylated bibenzyls and flavonoids from Macaranga kurzii.

  2014cited by this paper
• Four new bibenzyl derivatives from Dendrobium sinense

  2014cited by this paper
• Phytochemical study guided by the myorelaxant activity of the crude extract, fractions and constituent from stem bark of Hymenaea courbaril L.

  2013cited by this paper
• Larvicidal activity against Aedes aegypti of pacharin from Bauhinia acuruana

  2013cited by this paper
• Two New Diphenylethylenes from Arundina graminifolia and Their Cytotoxicity

  2013cited by this paper
• STEROIDS AND TRITERPENE FROM THE BARK OF UNONOPSIS GUATTERIOIDES R. E. FR. (ANONNACEAE)

  2012cited by this paper
• A new natural spiro heterocyclic compound and the cytotoxic activity of the secondary metabolites from Juniperus brevifolia leaves.

  2011cited by this paper
• Chemical Composition and Larvicidal Effects of Essential Oil from Bauhinia acuruana (Moric) against Aedes aegypti

  2011cited by this paper
• Chemical composition and biological potential of plants from the genus Bauhinia

  2009cited by this paper
• Multivariate chromatographic fingerprint preparation and authentication of plant material from the genus Bauhinia.

  2008cited by this paper
• Constituintes químicos de Ipomoea subincana Meisn. (Convolvulaceae)

  2008cited by this paper
• Heartwood extractives from the Amazonian trees Dipteryx odorata, Hymenaea courbaril, and Astronium lecointei and their antioxidant activities

  2008cited by this paper
• Two triterpenes lupanone and lupeol isolated and identified from Tamarindus indica linn.

  2007cited by this paper
• Bioactive compounds from Bauhinia purpurea possessing antimalarial, antimycobacterial, antifungal, anti-inflammatory, and cytotoxic activities.

  2007cited by this paper
• Antineoplastic agents. 551. Isolation and structures of bauhiniastatins 1-4 from Bauhinia purpurea

  2006cited by this paper
• Phenolic and terpenoid compounds from Chione venosa (sw.) urban var. venosa (Bois Bandé).

  2005cited by this paper
• Novel Biologically Active Bibenzyls from Bauhinia saccocalyx Pierre

  2004cited by this paper
• Bauhinia ser. Cansenia (Leguminosae: Caesalpinioideae) no Brasil

  2003cited by this paper
• An efficient synthesis of the four mono methylated isomers of (+)-catechin including the major metabolites and of some dimethylated and trimethylated analogues through selective protection of the catechol ring

  2002cited by this paper
• Antimalarial preracemosols A and B, possible biogenetic precursors of racemosol from Bauhinia malabarica Roxb.

  2000cited by this paper
• Flavonoid glycosides from Eugenia jambos.

  1994cited by this paper
• NMR study of some anthraquinones from rhubarb

  1992cited by this paper
• Antifungal compounds from Dioscorea batatas inoculated with Pseudomonas cichorii

  1987cited by this paper
• Use of stable 2,2,6,6-tetramethylpiperidine N-oxyl radical for the measurements of Lewis acidity of solvents

  1985cited by this paper
• Pacharin: a new dibenzo(2,3-6,7)oxepin derivative from bauhinia racemosa lamk

  1984cited by this paper
• Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays.

  1983cited by this paper
• Kinetic study of E2 eliminations from 2-thienylethyl bromides and toluene-p-sulphonates promoted by sodium ethoxide in ethanol

  1975cited by this paper

• Flavonoid in All Their Therapeutic Values: An Odyssey into the Phytochemistry and Pharmacology of Naturally Occurring Flavonoid from Genus Bauhinia

  2025cites this paper
• A review of natural products and small‐molecule therapeutics acting on central nervous system malignancies: Approaches for drug development, targeting pathways, clinical trials, and challenges

  2024cites this paper
• Dibenzo[b,f]oxepine Molecules Used in Biological Systems and Medicine

  2023cites this paper
• Methoxylated bibenzyls and isoflavones from Baphia massaiensis Taub

  2023cites this paper
• A review on plants possesses anti tubercular activity

  2023cites this paper
• Natural Dibenzo [b,f] oxepines, Pacharin and Bauhiniastatin-1, Isolated from Bauhinia acuruana Induce Apoptosis on Breast Cancer Cells via MCL-1 Protein Reduction

  2022cites this paper
• The effects of festidinol treatment on the D-galactose and aluminum chloride-induced Alzheimer-like pathology in mouse brain.

  2022cites this paper
• Hypoglycemic and hepatoprotective effects in adult zebrafish (Danio rerio) of fisetinidol isolated from Bauhinia pentandra: In vivo and in silico assays

  2022cites this paper
• Water availability and substrate in the emergency and initial development of Bauhinia scandens L.

  2021cites this paper
• Bauhinia pulchella: chemical constituents, antioxidant and alpha-glucosidase inhibitory activities

  2021cites this paper
• Chemical composition, larvicidal and cytotoxic activities of the leaf essential oil of Bauhinia cheilantha (Bong.) Steud

  2020cites this paper
• Bauhinia holophylla (Bong.) Steud. leaves-derived extracts as potent anti-dengue serotype 2

  2019cites this paper