Type III Secretion in Yersinia: Injectisome or Not?

Under certain conditions, pathogens like Yersinia secrete high levels of proteins. This ability correlates with cytotoxicity and virulence. The complete inactivity of the secreted proteins when added directly to host cells stimulated research to disclose this “non-AB toxin mechanism” of virulence, and eventually led to the discovery of the type III secretion mechanism and the “injection model” for virulence effector targeting. Recent studies question this model and suggest that the T3SS effector-targeting mechanism may resemble the classical AB toxin delivery mechanism.

• Publication year

  2012

• Venue

  PLoS Pathogens

• Publication date

  2012-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1371/journal.ppat.1002669PMID 22589714PMCID 3349746
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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