Intimal Smooth Muscle Cells as a Target for Peroxisome Proliferator-Activated Receptor-&ggr; Ligand Therapy

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Circulation Research

• Publication date

  2002-08-09

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1161/01.RES.0000029080.15742.85PMID 12169646
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cyclooxygenase isozyme expression and intimal hyperplasia in a rat model of balloon angioplasty.

  2002cited by this paper
• Oxidized Alkyl Phospholipids Are Specific, High Affinity Peroxisome Proliferator-activated Receptor γ Ligands and Agonists*

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• PPAR-γ dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation

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• Dual DNA-binding specificity of peroxisome-proliferator-activated receptor gamma controlled by heterodimer formation with retinoid X receptor alpha.

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• The role of PPAR-gamma in macrophage differentiation and cholesterol uptake.

  2001cited by this paper
• Peroxisome Proliferator-activated Receptor γ-mediated Transcriptional Up-regulation of the Hepatocyte Growth Factor Gene Promoter via a Novel Composite cis-Acting Element*

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• Peroxisome proliferator-activated receptor gamma ligands inhibit retinoblastoma phosphorylation and G1--> S transition in vascular smooth muscle cells.

  2000cited by this paper
• The Nuclear Receptor PPARγ and Immunoregulation: PPARγ Mediates Inhibition of Helper T Cell Responses1

  2000cited by this paper
• Peroxisome Proliferator-Activated Receptor γ Activators Downregulate Angiotensin II Type 1 Receptor in Vascular Smooth Muscle Cells

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• Activation of Human T Lymphocytes Is Inhibited by Peroxisome Proliferator-activated Receptor γ (PPARγ) Agonists

  2000cited by this paper
• Expression and Function of PPARγ in Rat and Human Vascular Smooth Muscle Cells

  2000cited by this paper
• Ligand type-specific Interactions of Peroxisome Proliferator-activated Receptor γ with Transcriptional Coactivators*

  2000cited by this paper
• Peroxisome proliferator–activated receptor γ ligands inhibit development of atherosclerosis in LDL receptor–deficient mice

  2000cited by this paper
• Bisphenol A diglycidyl ether (BADGE) is a PPARγ agonist in an ECV304 cell line

  2000cited by this paper
• Peroxisome Proliferator-activated Receptor γ Ligands Inhibit Retinoblastoma Phosphorylation and G1 → S Transition in Vascular Smooth Muscle Cells*

  2000cited by this paper
• Expression and function of PPARgamma in rat and human vascular smooth muscle cells.

  2000cited by this paper
• Peroxisome proliferator-activated receptor gamma activators downregulate angiotensin II type 1 receptor in vascular smooth muscle cells.

  2000cited by this paper
• Expression of macrophage (Mphi) scavenger receptor, CD36, in cultured human aortic smooth muscle cells in association with expression of peroxisome proliferator activated receptor-gamma, which regulates gain of Mphi-like phenotype in vitro, and its implication in atherogenesis.

  2000cited by this paper
• Peroxisome proliferator‐activated receptors in the cardiovascular system

  2000cited by this paper
• Activation of human T lymphocytes is inhibited by peroxisome proliferator-activated receptor gamma (PPARgamma) agonists. PPARgamma co-association with transcription factor NFAT.

  2000cited by this paper
• Peroxisome proliferator-activated receptor gamma ligands inhibit development of atherosclerosis in LDL receptor-deficient mice.

  2000cited by this paper
• Augmented expression of cyclooxygenase-2 in human atherosclerotic lesions.

  1999cited by this paper
• Fatty acid translocase/CD36 mediates the uptake of palmitate by type II pneumocytes.

  1999cited by this paper
• A peroxisome proliferator-activated receptor gamma ligand inhibits adipocyte differentiation.

  1999cited by this paper
• The peroxisome proliferator‐activated receptorγ (PPARγ) as a regulator of monocyte/macrophage function

  1999cited by this paper
• Cyclo-oxygenase-2 in vascular smooth muscle.

  1999cited by this paper
• Peroxisome Proliferator-activated Receptor γ Ligands Are Potent Inhibitors of Angiogenesis in Vitro and in Vivo *

  1999cited by this paper
• A peroxisome proliferator-activated receptor g ligand inhibits adipocyte differentiation

  1999cited by this paper
• PPAR gamma-ligands inhibit migration mediated by multiple chemoattractants in vascular smooth muscle cells.

  1999cited by this paper
• Cyclooxygenase-2 is widely expressed in atherosclerotic lesions affecting native and transplanted human coronary arteries and colocalizes with inducible nitric oxide synthase and nitrotyrosine particularly in macrophages.

  1999cited by this paper
• Interleukin 1β Induces Type II-secreted Phospholipase A2 Gene in Vascular Smooth Muscle Cells by a Nuclear Factor κB and Peroxisome Proliferator-activated Receptor-mediated Process*

  1999cited by this paper
• Endothelial Cell Apoptosis Induced by the Peroxisome Proliferator-activated Receptor (PPAR) Ligand 15-Deoxy-Δ12,14-prostaglandin J2 *

  1999cited by this paper
• The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation.

  1998cited by this paper
• PPAR-γ agonists inhibit production of monocyte inflammatory cytokines

  1998cited by this paper
• The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation

  1998cited by this paper
• Activation of human aortic smooth-muscle cells is inhibited by PPARα but not by PPARγ activators

  1998cited by this paper
• Smooth muscle cell heterogeneity: patterns of gene expression in vascular smooth muscle cells in vitro and in vivo.

  1998cited by this paper
• Peroxisome proliferator-activated receptor gamma activators inhibit gene expression and migration in human vascular smooth muscle cells.

  1998cited by this paper
• Plasminogen activator expression in rat arterial smooth muscle cells depends on their phenotype and is modulated by cytokines.

  1998cited by this paper
• PPARγ Promotes Monocyte/Macrophage Differentiation and Uptake of Oxidized LDL

  1998cited by this paper
• Differential induction of cyclooxygenase-2 in human arterial and venous smooth muscle: role of endogenous prostanoids.

  1998cited by this paper
• PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL.

  1998cited by this paper
• Activation of human aortic smooth-muscle cells is inhibited by PPARalpha but not by PPARgamma activators.

  1998cited by this paper
• PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines.

  1998cited by this paper
• Prostaglandins Promote and Block Adipogenesis through Opposing Effects on Peroxisome Proliferator-activated Receptor γ*

  1998cited by this paper
• Expression of the peroxisome proliferator-activated receptor gamma (PPARgamma) in human atherosclerosis and regulation in macrophages by colony stimulating factors and oxidized low density lipoprotein.

  1998cited by this paper
• Induction of cyclooxygenase-2 in human saphenous vein and internal mammary artery.

  1997cited by this paper
• DNA Binding Properties of Peroxisome Proliferator-activated Receptor Subtypes on Various Natural Peroxisome Proliferator Response Elements

  1997cited by this paper
• Cellular retinol-binding protein-1 is expressed by distinct subsets of rat arterial smooth muscle cells in vitro and in vivo.

  1997cited by this paper
• Peroxisome Proliferator-activated Receptors α and γ Are Activated by Indomethacin and Other Non-steroidal Anti-inflammatory Drugs*

  1997cited by this paper
• Characterization of the induction of nitric oxide synthase and cyclo‐oxygenase in rat aorta in organ culture

  1997cited by this paper
• Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs.

  1997cited by this paper
• Identification, Characterization, and Tissue Distribution of Human Peroxisome Proliferator-activated Receptor (PPAR) Isoforms PPARγ2 versus PPARγ1 and Activation with Retinoid X Receptor Agonists and Antagonists*

  1997cited by this paper
• Peroxisome proliferator-activated receptors: a nuclear receptor signaling pathway in lipid physiology.

  1996cited by this paper
• Differential activation of adipogenesis by multiple PPAR isoforms.

  1996cited by this paper
• Characterization of cloned aortic smooth muscle cells from young rats.

  1994cited by this paper
• Differential expression and activation of a family of murine peroxisome proliferator-activated receptors.

  1994cited by this paper
• Regulation of cyclooxygenase-2 expression in aortic smooth muscle cells.

  1994cited by this paper
• Rat aortic smooth muscle cells isolated from different layers and at different times after endothelial denudation show distinct biological features in vitro.

  1994cited by this paper
• Rat carotid neointimal smooth muscle cells reexpress a developmentally regulated mRNA phenotype during repair of arterial injury.

  1992cited by this paper
• Smooth muscle diversity in arterial wound repair.

  1990cited by this paper
• Production of platelet-derived growth factor-like molecules by cultured arterial smooth muscle cells accompanies proliferation after arterial injury.

  1986cited by this paper
• Restoration of prostacyclin synthase in vascular smooth muscle cells after aspirin treatment: regulation by epidermal growth factor.

  1985cited by this paper
• Dual DNA-binding specificity of peroxisome-proliferator-activated receptor γ controlled by heterodimer formation with retinoid X receptor α

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  2012cites this paper
• Effects of PPARγ ligands on vascular tone.

  2012cites this paper
• Adiponectin is required for PPARγ-mediated improvement of endothelial function in diabetic mice.

  2011cites this paper
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  2011cites this paper
• Pregnane X receptor regulates drug metabolism and transport in the vasculature and protects from oxidative stress

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• Endogenous Epoxygenases Are Modulators of Monocyte/Macrophage Activity

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• Upregulation of peroxisome proliferator‐activated receptor‐γ and NADPH oxidases are involved in restenosis after balloon injury

  2009cites this paper
• PPARs and the Cardiovascular System

  2009cites this paper
• Effect of a peroxisome proliferator-activated receptor gamma sumoylation mutant on neointimal formation after balloon injury in rats.

  2009cites this paper
• Peroxisome proliferator-activated receptors: a therapeutic target in COPD?

  2008cites this paper
• Pioglitazone Induces Apoptosis in Human Vascular Smooth Muscle Cells from Diabetic Patients Involving the Transforming Growth Factor-β/Activin Receptor-Like Kinase-4/5/7/Smad2 Signaling Pathway

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• PPARγ Gene Transfer Sustains Apoptosis, Inhibits Vascular Smooth Muscle Cell Proliferation, and Reduces Neointima Formation After Balloon Injury in Rats

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• This Review Is Part of a Thematic Series on Nuclear Receptor Signaling, Which Includes the following Articles: Peroxisome Proliferator-activated Receptors and Atherogenesis: Regulators of Gene Expression in Vascular Cells Nuclear Receptor Signaling in the Control of Cholesterol Homeostasis Nuclear R

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