Partially adenosine deaminase-deficient mice develop pulmonary fibrosis in association with adenosine elevations.

No abstract is available for this paper.

• Publication year

  2006

• Venue

  American Journal of Physiology - Lung cellular and Molecular Physiology

• Publication date

  2006-03-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1152/AJPLUNG.00258.2005PMID 16258000
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A protective role for the A1 adenosine receptor in adenosine-dependent pulmonary injury.

  2005cited by this paper
• Synergy between A2B adenosine receptors and hypoxia in activating human lung fibroblasts.

  2005influential reference
• Adenosine-Dependent Pulmonary Fibrosis in Adenosine Deaminase-Deficient Mice1

  2005cited by this paper
• Back to the future: historical perspective on the pathogenesis of idiopathic pulmonary fibrosis.

  2005cited by this paper
• Mechanisms of pulmonary fibrosis.

  2004influential reference
• A(2B) adenosine receptors increase cytokine release by bronchial smooth muscle cells.

  2004cited by this paper
• Adenosine-Activated Mast Cells Induce IgE Synthesis by B Lymphocytes: An A2B-Mediated Process Involving Th2 Cytokines IL-4 and IL-13 with Implications for Asthma12

  2004influential reference
• Fibrotic disease and the T(H)1/T(H)2 paradigm.

  2004cited by this paper
• Adenosine: an endogenous regulator of innate immunity.

  2004cited by this paper
• A2B Adenosine Receptors Increase Cytokine Release by Bronchial Smooth Muscle Cells

  2004cited by this paper
• Early Growth Response Gene 1–mediated Apoptosis Is Essential for Transforming Growth Factor β1–induced Pulmonary Fibrosis

  2004cited by this paper
• Fibrotic disease and the TH1/TH2 paradigm

  2004cited by this paper
• The role of gp130/IL-6 cytokines in the development of pulmonary fibrosis: critical determinants of disease susceptibility and progression?

  2003cited by this paper
• Adenosine mediates IL-13-induced inflammation and remodeling in the lung and interacts in an IL-13-adenosine amplification pathway.

  2003cited by this paper
• New insights into the pathogenesis of asthma.

  2003cited by this paper
• Too much of a good thing: adenosine overload in adenosine-deaminase-deficient mice.

  2003cited by this paper
• Th1 Cytokines Regulate Adenosine Receptors and Their Downstream Signaling Elements in Human Microvascular Endothelial Cells 1

  2003cited by this paper
• International Union of Pharmacology: Approaches to the Nomenclature of Voltage-Gated Ion Channels

  2003cited by this paper
• Adenosine in exhaled breath condensate in healthy volunteers and in patients with asthma

  2002cited by this paper
• International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors.

  2001influential reference
• Compartmentalized autocrine signaling to cystic fibrosis transmembrane conductance regulator at the apical membrane of airway epithelial cells

  2001cited by this paper
• Adenosine-Dependent Airway Inflammation and Hyperresponsiveness in Partially Adenosine Deaminase-Deficient Mice1

  2001cited by this paper
• Pulmonary fibrosis: a cellular overreaction or a failure of communication?

  2001cited by this paper
• Fibrosis of the lung and other tissues: new concepts in pathogenesis and treatment.

  2001influential reference
• Interleukin-13 Induces Tissue Fibrosis by Selectively Stimulating and Activating Transforming Growth Factor β1

  2001cited by this paper
• Molecular approach to adenosine receptors: receptor-mediated mechanisms of tissue protection.

  2001cited by this paper
• The Use of Enzyme Therapy to Regulate the Metabolic and Phenotypic Consequences of Adenosine Deaminase Deficiency in Mice

  2000cited by this paper
• Adenosine and inosine increase cutaneous vasopermeability by activating A(3) receptors on mast cells.

  2000cited by this paper
• IFN-gamma up-regulates the A2B adenosine receptor expression in macrophages: a mechanism of macrophage deactivation.

  1999cited by this paper
• Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production.

  1999cited by this paper
• Adenosine Deaminase-deficient Mice Generated Using a Two-stage Genetic Engineering Strategy Exhibit a Combined Immunodeficiency*

  1998cited by this paper
• Production of interleukin 13 by alveolar macrophages from normal and fibrotic lung.

  1998cited by this paper
• The role of IL‐5 in bleomycin‐induced pulmonary fibrosis

  1998cited by this paper
• Adenosine stimulation of DNA synthesis in human endothelial cells.

  1997cited by this paper
• Adenovector-mediated gene transfer of active transforming growth factor-beta1 induces prolonged severe fibrosis in rat lung.

  1997cited by this paper
• A type 2 (Th2‐like) pattern of immune response predominates in the pulmonary interstitium of patients with cryptogenic fibrosing alveolitis (CFA)

  1995cited by this paper
• Adenosine stimulates DNA fragmentation in human thymocytes by Ca(2+)-mediated mechanisms.

  1994cited by this paper
• Subsets of murine lung fibroblasts express membrane-bound and soluble IL-4 receptors. Role of IL-4 in enhancing fibroblast proliferation and collagen synthesis.

  1994cited by this paper
• Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts

  1993cited by this paper
• Adenosine in bronchoalveolar lavage fluid in asthma.

  1993cited by this paper
• Airway responsiveness to adenosine 5'-monophosphate in chronic obstructive pulmonary disease is determined by smoking.

  1993cited by this paper
• Effects of (R)-deoxycoformycin (pentostatin) on intrauterine nucleoside catabolism and embryo viability in the pregnant mouse.

  1992cited by this paper
• In vivo levels and in vitro production of interferon‐gamma in fibrosing interstitial lung diseases

  1992cited by this paper
• Transforming growth factor beta 1 is present at sites of extracellular matrix gene expression in human pulmonary fibrosis.

  1991cited by this paper
• Clinical deterioration in patients with idiopathic pulmonary fibrosis: causes and assessment.

  1990cited by this paper
• Adenosine-induced bronchoconstriction in asthma. Antagonism by inhaled theophylline.

  1984cited by this paper
• Pulmonary Diseases and Disorders

  1980cited by this paper
• Potentiation of mast cell mediator release by adenosine.

  1978cited by this paper

• Adenosine-Specific Transcriptional Programs in Murine Connective Tissue-Type Mast Cells.

  2026cites this paper
• Adenosine receptor signalling as a driver of pulmonary fibrosis.

  2023cites this paper
• Ivy Leaf Dry Extract EA 575® Has an Inhibitory Effect on the Signalling Cascade of Adenosine Receptor A2B

  2023cites this paper
• Topical Adenosine Inhibits Inflammation and Mucus Production in Viral Acute Rhinosinusitis

  2022cites this paper
• Purinergic signaling in systemic sclerosis.

  2021cites this paper
• Adenosine at the Interphase of Hypoxia and Inflammation in Lung Injury

  2021cites this paper
• Recombinant Adenosine Deaminase Ameliorates Inflammation, Vascular Disease, and Fibrosis in Preclinical Models of Systemic Sclerosis

  2020cites this paper
• Opposing Effects of Adenosine and Inosine in Human Subcutaneous Fibroblasts May Be Regulated by Third Party ADA Cell Providers

  2020cites this paper
• Microvascular heart involvement in systemic autoimmune diseases: The purinergic pathway and therapeutic insights from the biology of the diseases.

  2019cites this paper
• The CD73/Ado System—A New Player in RT Induced Adverse Late Effects

  2019cites this paper
• Role of A2B adenosine receptor-dependent adenosine signaling in multi-walled carbon nanotube-triggered lung fibrosis in mice

  2019cites this paper
• Methyl-CpG-binding protein 2 mediates antifibrotic effects in scleroderma fibroblasts

  2018cites this paper
• Switching-Off Adora2b in Vascular Smooth Muscle Cells Halts the Development of Pulmonary Hypertension

  2018influential citation
• Extracellular adenosine: a critical signal in liver fibrosis.

  2018cites this paper
• Characterisation of the expression of adenosine and estrogen receptors in myofibroblast differentiation in Peyronie's disease

  2018cites this paper
• The Antifibrotic Effect of A2B Adenosine Receptor Antagonism in a Mouse Model of Dermal Fibrosis

  2018cites this paper
• Modeling DNA damage-induced pneumopathy in mice: insight from danger signaling cascades

  2017cites this paper
• Adenosine and adenosine receptors in the pathogenesis and treatment of rheumatic diseases

  2017cites this paper
• ROLE AND REGULATION OF SPHINGOSINE 1-PHOSPHATE IN ERYTHROCYTE

  2017cites this paper
• Adenosine contribution to normal renal physiology and chronic kidney disease.

  2017cites this paper
• Purinergic signalling links mechanical breath profile and alveolar mechanics with the pro-inflammatory innate immune response causing ventilation-induced lung injury

  2017cites this paper
• Extracellular adenosine levels are associated with the progression and exacerbation of pulmonary fibrosis

  2016cites this paper
• Extracellular nucleotide regulation and signaling in cardiac fibrosis.

  2016cites this paper
• Evaluation of Serum Adenosine Deaminase in Cystic Fibrosis Patients in an Iranian Referral Hospital

  2016influential citation
• Simvastatin up-regulates adenosine deaminase and suppresses osteopontin expression in COPD patients through an IL-13-dependent mechanism

  2016cites this paper
• Extracellular Adenosine Production by ecto-5'-Nucleotidase (CD73) Enhances Radiation-Induced Lung Fibrosis.

  2016cites this paper
• SEGEL: A Web Server for Visualization of Smoking Effects on Human Lung Gene Expression

  2015cites this paper
• Effects of A2BR on the biological behavior of mouse renal fibroblasts during hypoxia.

  2015cites this paper
• Postnatal development and LPS responsiveness of pulmonary adenosine receptor expression and of adenosine-metabolizing enzymes in mice

  2014cites this paper
• Cellular mechanisms of tissue fibrosis. 7. New insights into the cellular mechanisms of pulmonary fibrosis.

  2014cites this paper
• Elevated adenosine signaling via adenosine A2B receptor induces normal and sickle erythrocyte sphingosine kinase 1 activity.

  2014cites this paper
• Activation of adenosine receptor A2A increases HSC proliferation and inhibits death and senescence by down-regulation of p53 and Rb

  2014cites this paper
• Excess adenosine A2B receptor signaling contributes to priapism through HIF‐1α mediated reduction of PDE5 gene expression

  2014cites this paper
• The purinone in bibroblasts of the human subcutaneous tissue - A contribution to elucidate the pathogenesis myofascial pain

  2014cites this paper
• Angiogénesis pulmonar mediada por adenosina vía CXCL1/CXCR2

  2013cites this paper
• The role of the adenosinergic system in lung fibrosis.

  2013cites this paper
• Effect of Diabetes/Hyperglycemia on the Rat Retinal Adenosinergic System

  2013cites this paper
• Adenosine signaling during acute and chronic disease states

  2013cites this paper
• Adenosine signaling pathways as potential therapeutic targets in respiratory disease

  2013cites this paper
• Caffeine induces alveolar apoptosis in the hyperoxia-exposed developing mouse lung

  2013cites this paper
• Adenosine A2A receptor activation stimulates collagen production in sclerodermic dermal fibroblasts either directly and through a cross-talk with the cannabinoid system

  2012cites this paper
• metabolic defects deaminase (ADA)-deficient mice and corrects their immune and Ex vivo gene therapy with lentiviral vectors rescues adenosine

  2012cites this paper
• Lung Complications in Adenosine Deaminase (ADA) Deficiency: A Mouse Model for the Human Disease

  2012cites this paper
• Modern concepts on the role of inflammation in pulmonary fibrosis.

  2011cites this paper
• Ecto-5′-Nucleotidase (CD73) Decreases Mortality and Organ Injury in Sepsis

  2011cites this paper
• The resurgence of A2B adenosine receptor signaling.

  2011cites this paper
• Animal Models of Airway Diseases

  2011cites this paper
• Hyaluronan fragments promote inflammation by down-regulating the anti-inflammatory A2a receptor.

  2011cites this paper
• A2B adenosine receptor-mediated induction of IL-6 promotes CKD.

  2011cites this paper
• Recombinant Adeno-Associated Virus-Mediated Gene Transfer for the Potential Therapy of Adenosine Deaminase-Deficient Severe Combined Immune Deficiency

  2011cites this paper
• Adenosine deaminase levels in premature infants with respiratory distress syndrome and bronchopulmonary dysplasia

  2011cites this paper
• Purinergic signaling in wound healing and airway remodeling.

  2011cites this paper
• The Role of IL-6 in Adenosine-Mediated Pulmonary Fibrosis

  2011influential citation
• Pro-inflammatory role of P2Y6 receptor signalling during vascular inflammation

  2011cites this paper
• A2B adenosine receptor contributes to penile erection via PI3K/AKT signaling cascade‐mediated eNOS activation

  2011cites this paper
• Fundamentals of Inflammation

  2010cites this paper
• THE ROLE OF A2B ADENOSINE RECEPTOR SIGNALING IN ADENOSINE DEPENDENT LUNG DISEASE

  2010cites this paper
• Adenosine in fibrosis

  2010cites this paper
• Rol' adenozina i ego retseptorov v patofiziologii zabolevaniy bronkholegochnoy sistemy

  2010cites this paper
• Gender-specific association of ADA genetic polymorphism with human longevity

  2010cites this paper
• Increased adenosine contributes to penile fibrosis, a dangerous feature of priapism, via A2B adenosine receptor signaling

  2010cites this paper
• Adenosine deaminase enzyme therapy prevents and reverses the heightened cavernosal relaxation in priapism.

  2010cites this paper
• Regulatory T cell-mediated resolution of lung injury: identification of potential target genes via expression profiling.

  2010cites this paper
• Attenuation of chronic pulmonary inflammation in A2B adenosine receptor knockout mice.

  2010cites this paper
• Enhanced Airway Inflammation and Remodeling in Adenosine Deaminase-Deficient Mice Lacking the A2B Adenosine Receptor1

  2009cites this paper
• Adenosine induces loss of actin stress fibers and inhibits contraction in hepatic stellate cells via Rho inhibition

  2009cites this paper
• The adenosine a2a receptor inhibits matrix-induced inflammation in a novel fashion.

  2009cites this paper
• Adenosine signaling and the regulation of chronic lung disease.

  2009cites this paper
• Genomic responses of salmonids to pathogenic agents and nutritional interventions

  2009cites this paper
• Local and systemic gene expression responses of Atlantic salmon (Salmo salar L.) to infection with the salmon louse (Lepeophtheirus salmonis)

  2008cites this paper
• Pharmacological blockade of A2A receptors prevents dermal fibrosis in a model of elevated tissue adenosine.

  2008cites this paper
• Excess adenosine in murine penile erectile tissues contributes to priapism via A2B adenosine receptor signaling.

  2008cites this paper
• Role of adenosine in inflammatory processes

  2008cites this paper
• A3 adenosine receptor signaling influences pulmonary inflammation and fibrosis.

  2008cites this paper
• Adenosine Promotes IL-6 Release in Airway Epithelia1

  2008cites this paper
• Major Histocompatibility Class II Transactivator Expression in Smooth Muscle Cells from A2b Adenosine Receptor Knock-out Mice

  2008cites this paper
• Adenosine A2A Receptor Blockade or Deletion Diminishes Fibrocyte Accumulation in the Skin in a Murine Model of Scleroderma, Bleomycin-induced Fibrosis

  2008cites this paper
• Extracellular nucleotides regulate CCL20 release from human primary airway epithelial cells, monocytes and monocyte‐derived dendritic cells

  2007cites this paper
• Enhanced CXCL1 production and angiogenesis in adenosine‐mediated lung disease

  2007cites this paper
• Accelerated Variant of Idiopathic Pulmonary Fibrosis: Clinical Behavior and Gene Expression Pattern

  2007cites this paper
• Adenosine receptors: therapeutic aspects for inflammatory and immune diseases

  2006cites this paper
• Role of A2B adenosine receptor signaling in adenosine-dependent pulmonary inflammation and injury.

  2006cites this paper
• Ex vivo gene therapy with lentiviral vectors rescues adenosine deaminase (ADA)-deficient mice and corrects their immune and metabolic defects.

  2006cites this paper
• Mortality and Organ Injury in Sepsis -Nucleotidase (CD73) Decreases ¢ Ecto-5

  year unknowncites this paper