Oxidation of 4‐hydroxy‐2‐nonenal by succinic semialdehyde dehydrogenase (ALDH5A)

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Journal of Neurochemistry

• Publication date

  2003-07-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1046/j.1471-4159.2003.01839.xPMID 12871571
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Oxidation of 4-hydroxynonenal in rat brain slices.

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  1999cited by this paper
• Four-hydroxynonenal, a product of lipid peroxidation, is increased in the brain in Alzheimer's disease.

  1998cited by this paper
• Mechanism for benomyl action as a mitochondrial aldehyde dehydrogenase inhibitor in mice.

  1998cited by this paper
• 4-Hydroxybutyric acid and the clinical phenotype of succinic semialdehyde dehydrogenase deficiency, an inborn error of GABA metabolism.

  1998cited by this paper
• 4‐Hydroxy‐2‐Nonenal Pyrrole Adducts in Human Neurodegenerative Disease

  1997cited by this paper
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  1997cited by this paper
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  1997cited by this paper
• Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson disease.

  1996cited by this paper
• Heterotetramers of Human Liver Mitochondrial (Class 2) Aldehyde Dehydrogenase Expressed in Escherichia coli

  1996cited by this paper
• Molecular Cloning of the Mature NAD-dependent Succinic Semialdehyde Dehydrogenase from Rat and Human

  1995cited by this paper
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  1995cited by this paper
• Succinic semialdehyde dehydrogenase from mammalian brain: subunit analysis using polyclonal antiserum.

  1992cited by this paper
• Identification of human liver aldehyde dehydrogenases that catalyze the oxidation of aldophosphamide and retinaldehyde.

  1992cited by this paper
• Oxidation and reduction of 4-hydroxyalkenals catalyzed by isozymes of human alcohol dehydrogenase.

  1991cited by this paper
• Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes.

  1991cited by this paper
• The oxidation of α-β unsaturated aldehydic products of lipid peroxidation by rat liver aldehyde dehydrogenases☆

  1987cited by this paper
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  1987cited by this paper
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  1987cited by this paper
• 4‐Hydroxyalk‐2‐enals are substrates for glutathione transferase

  1985cited by this paper
• Distribution and Properties of Aldehyde Dehydrogenase in Regions of Rat Brain

  1984cited by this paper
• Inhibition of Aldehyde Dehydrogenases in Rat Brain and Liver by Disulfiram and Coprine

  1982influential reference
• Enzymology and subcellular localization of aldehyde oxidation in rat liver. Oxidation of 3,4-dihydroxyphenylacetaldehyde derived from dopamine to 3,4-dihydroxyphenylacetic acid.

  1981cited by this paper

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  2017cites this paper
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  2017cites this paper
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