Response of mature unprimed CD8+ T cells to Mlsa determinants

Contrary to existing dogma, evidence is presented that proliferative responses of mature unprimed T cells to Mlsa antigens involve CD8+ cells as well as CD4+ cells. The response of CD8+ cells to Mlsa antigens proved to be heavily dependent on help from CD4+ cells, and responses were stronger in three I-E+ strain combinations than in an I- E- combination. In I-E+ combinations, CD8+ blast cells accounted for 20- 25% of the blasts generated from unseparated T cells responding to Mlsa- bearing stimulator cells in vitro; similar findings applied to blast cells generated in vivo. The observation that the majority (greater than or equal to 50%) of Mlsa-stimulated CD8+ cells (and CD4+ cells) were V beta 6+ indicated that CD8+ cells respond to Mlsa antigens, per se, rather than to nonspecific stimuli. Whether CD4+ and CD8+ cells use the same or different H-2-restricting elements to respond to Mlsa antigens has yet to be resolved.

• Publication year

  1990

• Venue

  Journal of Experimental Medicine

• Publication date

  1990-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1084/JEM.171.3.953PMID 1689765PMCID 2187773
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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