AVALIAÇÃO DA CITOTOXICIDADE DE BIFLAVONÓIDES ISOLADOS DE OURATEA SPECTABILIS (OCHNACEAE) EM CÉLULAS DE CÓRNEA DE COELHO SIRC

RESUMO A citotoxicidade dos biflavonóides 6,6"- bigenkwanin (OSP-1), 7,7"- dimetoxi-agathisflavona (OSP-2) e tetradimethoxiflavona (OSP-1 Met) isolados de folhas de Ouratea spectabilis foram avaliadas em linhagem celular de córnea de coelho, SIRC pela determinação da medida espectofotométrica nas concentrações das substâncias que inibem a absorbância em 50% do controle. OSP-1, OSP-2 e OSP-1 Met apresentaram IC50 nas concentrações de 381,9 ± 22,29; 436,74 ± 22,05 e 359,7 ± 24,25 µg/mL, respectivamente. Estes compostos apresentam atividade inibidora para a aldose redutase, enzima relacionada com o início da formação da catarata em diabéticos.

• Publication year

  2002

• Venue

  Arquivos do Instituto Biológico

• Publication date

  2002-04-30

• Fields of study

  Biology, Chemistry

• Identifiers
  DOI 10.1590/1808-1657v69n4p0952002
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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