Nuclear Accumulations of p53 and Mdm2 are Accompanied by Reductions in c-Abl and p300 in Zinc-Depleted Human Hepatoblastoma Cells

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Experimental biology and medicine

• Publication date

  2006-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1177/153537020623100516PMID 16636310
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2001influential reference
• Zinc status affects p53, gadd45, and c-fos expression and caspase-3 activity in human bronchial epithelial cells.

  2001cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  1999cited by this paper
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  1999cited by this paper
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  1999cited by this paper
• p21/p53, cellular growth control and genomic integrity.

  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1997cited by this paper
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• Effects of p53 mutation on tumor progression: recent insights from mouse tumor models.

  1996cited by this paper
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  1993cited by this paper
• What the papers say: The p53‐mdm2 autoregulatory feedback loop: A paradigm for the regulation of growth control by p53?

  1993cited by this paper
• A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia.

  1992cited by this paper
• Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells.

  1989cited by this paper
• Measurement of apolipoprotein mRNA by DNA-excess solution hybridization with single-stranded probes.

  1986cited by this paper

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  2009cites this paper
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  2008cites this paper
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