Investigation of Formulation and Process of Lyophilised Orally Disintegrating Tablet (ODT) Using Novel Amino Acid Combination

Lyophilised orally disintegrating tablets (ODTs) have achieved a great success in overcoming dysphagia associated with conventional solid dosage forms. However, the extensive use of saccharides within the formulation limits their use in treatment of chronic illnesses. The current study demonstrates the feasibility of using combination of proline and serine to formulate zero sacharide ODTs and investigates the effect of freezing protocol on sublimation rate and tablets characteristics. The results showed that inclusion of proline and serine improved ODT properties when compared to individual counterparts. Additionally, annealing the ODTs facilitated the sublimation process and shortened the disintegration time.

• Publication year

  2010

• Venue

  Pharmaceutics

• Publication date

  2010-01-04

• Fields of study

  Medicine, Materials Science, Chemistry

• Identifiers
  DOI 10.3390/pharmaceutics2010001PMID 27721339PMCID 3968345
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2009influential reference
• In vitro and in vivo evaluation of a fast-disintegrating lyophilized dry emulsion tablet containing griseofulvin.

  2007cited by this paper
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  2006cited by this paper
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  2006cited by this paper
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  2004cited by this paper
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  2002cited by this paper
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  2002cited by this paper
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  2002cited by this paper
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  2001cited by this paper
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  2001cited by this paper
• Fast-Melting Tablets: Developments and Technologies

  2001cited by this paper
• Recent technological advances in oral drug delivery - a review.

  2000cited by this paper
• Fabrication of porous gelatin scaffolds for tissue engineering.

  1999cited by this paper
• Formulation of a lyophilized dry emulsion tablet for the delivery of poorly soluble drugs

  1998cited by this paper
• Scanning electron microscopy of freeze-dried preparations: relationship of morphology to freeze-drying parameters.

  1992cited by this paper
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  1990cited by this paper
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  1987cited by this paper

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  2013cites this paper
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  2013cites this paper
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  2013cites this paper
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  2012cites this paper
• The impact of ageing on the barriers to drug delivery.

  2012cites this paper
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  2011influential citation
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  2011cites this paper