Behavioral abnormalities in APPSwe/PS1dE9 mouse model of AD-like pathology: comparative analysis across multiple behavioral domains.

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Neurobiology of Aging

• Publication date

  2015-09-01

• Fields of study

  Biology, Medicine, Psychology

• Identifiers
  DOI 10.1016/j.neurobiolaging.2015.05.010PMID 26089165
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Mouse Models of Alzheimer's Disease: Insight into Treatment

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• Aging, Memory, and Mild Cognitive Impairment

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• Diagnostic criteria for neuropathologic assessment of Alzheimer's disease.

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• Psychiatric Phenomena in Alzheimer's Disease. IV: Disorders of Behaviour

  1990cited by this paper
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