Neurobiological fundamentals of posttrumatic stress disorder – a possible role of circadian rhythms deregulations

Zespół stresu pourazowego jest złożonym zespołem zaburzeń lękowych wywołanym działaniem czynnika stresowego. Przypuszcza się, że patogeneza PTSD jest związana z zaburzeniem reakcji warunkowania strachu. Indukowane działaniem czynnika stresowego zmiany elektrofizjologiczne oraz neurohormonalne w takich strukturach jak hipokamp, ciała migdałowate, kora przedczołowa, jądro miejsca sinawego mogą sugerować zaburzenie czynnościowe innych obszarów w ośrodkowym układzie nerwowym, np. jądra nadskrzyżowaniowego. Silne pobudzenie jądra miejsca sinawego oraz jego wpływ na aktywności jądra nadskrzyżowaniowego może doprowadzić do zaburzeń okołodobowych zmian parametrów fizjologicznych. Liczne dane eksperymentalne wskazują na towarzyszące temu zespołowi zmiany aktywności osi podwzgórze-przysadka-nadnercza u ludzi i w zwierzęcych modelach. Ze względu na ograniczenia metodologiczne ocena zaburzeń okołodobowych zmian stężenia kortyzolu/kortykosteronu, hormonu adrenokortykotropowego oraz kortykoliberyny jest bardzo trudna. Wydaje się, że parametrem fizjologicznym, który nie będzie stwarzał tylu ograniczeń jest temperatura ciała. Badania prowadzone na modelu zwierzęcym wskazują, że ekspozycja na czynnik stresowy powoduje wzrost temperatury ciała zwierząt w czasie fazy jasnej cyklu dzień/noc. Wywołuje to „spłaszczenie” okołodobowego rytmu zmian temperatury ciała. Jednocześnie wykazano, że zmiany te są niezależne od aktywności jądra nadskrzyżowaniowego.

• Publication year

  2018

• Venue

  Postȩpy higieny i medycyny doświadczalnej

• Publication date

  2018-05-17

• Fields of study

  Not labeled

• Identifiers
  DOI 10.5604/01.3001.0012.0537
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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  2015cited by this paper
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  2015cited by this paper
• Psychosocial predator-based animal model of PTSD produces physiological and behavioral sequelae and a traumatic memory four months following stress onset.

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• A systematic review and meta-analysis of magnetic resonance imaging measurement of structural volumes in posttraumatic stress disorder.

  2015cited by this paper
• Blunted Corticosterone Response to Acute Predator Stress Results in Long-Term Spatial Memory Impairment

  2014cited by this paper
• Hippocampus and medial prefrontal cortex contributions to trace and contextual fear memory expression over time.

  2013cited by this paper
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  2013cited by this paper
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  2013cited by this paper
• Amygdala volume in combat-exposed veterans with and without posttraumatic stress disorder: a cross-sectional study.

  2012cited by this paper
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  2012cited by this paper
• The cross‐cultural validity of posttraumatic stress disorder: implications for DSM‐5

  2011cited by this paper
• Reduced amygdala serotonin transporter binding in posttraumatic stress disorder.

  2011cited by this paper
• Posttraumatic stress disorder: a history and a critique

  2010cited by this paper
• Circadian rhythms and memory formation

  2010cited by this paper
• Social defeat stress produces prolonged alterations in acoustic startle and body weight gain in male Long Evans rats.

  2010cited by this paper
• Differential Patterns of HPA Activity and Reactivity in Adult Posttraumatic Stress Disorder and Major Depressive Disorder

  2009cited by this paper
• Cycling Behavior and Memory Formation

  2009cited by this paper
• Trauma, Posttraumatic Stress Disorder, and Physical Illness: Findings from the General Population

  2009cited by this paper
• The influence of stress hormones on fear circuitry.

  2009cited by this paper
• Amygdala and hippocampal volumes and cognition in adult survivors of childhood abuse with dissociative disorders

  2008cited by this paper
• Glucocorticoid receptor activation is involved in producing abnormal phenotypes of single-prolonged stress rats: a putative post-traumatic stress disorder model.

  2007cited by this paper
• Neuroimaging in posttraumatic stress disorder and other stress-related disorders.

  2007cited by this paper
• Response variation following trauma: a translational neuroscience approach to understanding PTSD.

  2007cited by this paper
• [Molecular basis of stress-evoked psychiatric disturbances].

  2007cited by this paper
• A meta-analysis of structural brain abnormalities in PTSD.

  2006cited by this paper
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  2005cited by this paper
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  2005cited by this paper
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  2005cited by this paper
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  2005cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2004cited by this paper
• Stress integration after acute and chronic predator stress: differential activation of central stress circuitry and sensitization of the hypothalamo-pituitary-adrenocortical axis.

  2003cited by this paper
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  2002cited by this paper
• Circadian rhythms of body temperature and motor activity in rodents their relationships with the light-dark cycle.

  2001cited by this paper
• CSF norepinephrine concentrations in posttraumatic stress disorder.

  2001cited by this paper
• Chronic stress differentially regulates glucocorticoid negative feedback response in rats.

  2001cited by this paper
• The role of childhood trauma in the neurobiology of mood and anxiety disorders: preclinical and clinical studies.

  2001cited by this paper
• Lifetime events and posttraumatic stress disorder in 4 postconflict settings.

  2001cited by this paper
• Decreased hippocampal N-acetylaspartate in the absence of atrophy in posttraumatic stress disorder.

  2001cited by this paper
• Posttraumatic stress disorder and the nature of trauma

  2000cited by this paper
• Long-lasting consequences of a social conflict in rats: behavior during the interaction predicts subsequent changes in daily rhythms of heart rate, temperature, and activity.

  1999cited by this paper
• Human amygdala activation during conditioned fear acquisition and extinction: a mixed-trial fMRI study.

  1998cited by this paper
• Recurrent aggressive episodes entrain ultradian heart rate and core temperature rhythms.

  1998cited by this paper
• Elevated CSF corticotropin-releasing factor concentrations in posttraumatic stress disorder.

  1997cited by this paper
• Stress-Induced Changes in Circadian Rhythms of Body Temperature and Activity in Rats Are not Caused by Pacemaker Changes

  1997cited by this paper
• Stress-restress: effects on ACTH and fast feedback.

  1997cited by this paper
• A functional neuroanatomy of anxiety and fear: implications for the pathophysiology and treatment of anxiety disorders.

  1996cited by this paper
• Localization of 11 beta-hydroxysteroid dehydrogenase type II in human epithelial tissues.

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• Cortisol regulation in posttraumatic stress disorder and major depression: a chronobiological analysis.

  1996cited by this paper
• Changes in daily rhythms of body temperature and activity after a single social defeat in rats.

  1996cited by this paper
• Stress induced disorganization of circadian and ultradian rhythms: comparisons of effects of surgery and social stress.

  1996cited by this paper
• Posttraumatic stress disorder in the National Comorbidity Survey.

  1995cited by this paper
• Urinary catecholamine excretion in sexually abused girls.

  1994cited by this paper
• Long-term impairment of autonomic circadian rhythms after brief intermittent social stress.

  1993cited by this paper
• Paroxetine binding in the blood platelets of post-traumatic stress disorder patients.

  1993cited by this paper
• Criteria for rationally evaluating animal models of posttraumatic stress disorder.

  1993cited by this paper
• Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning.

  1992cited by this paper

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